Patents by Inventor Narasaiah Kolliputi

Narasaiah Kolliputi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALDA-1 treatment and prevention of pulmonary disease
    Patent number: 11185528
    Abstract: Methods of treating or preventing allergic or pulmonary diseases characterized by endothelial dysfunction with Alda-1 are presented. Treatment of pulmonary endothelial cells subjected to hyperoxia with Alda-1 showed an increase in ALDH2 activity and expression. Treatment with Alda-1 also illustrated a decrease in oxidative stress, a decrease in reactive oxygen species (ROS), a decrease in apoptosis, a decrease in inflammation and an enhancement of mitochondrial membrane potential.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: November 30, 2021
    Assignee: University of South Florida
    Inventors: Narasaiah Kolliputi, Richard F. Lockey, Lakshmi Galam
  • ALDA-1 TREATMENT AND PREVENTION OF PULMONARY DISEASE
    Publication number: 20200237716
    Abstract: Methods of treating or preventing allergic or pulmonary diseases characterized by endothelial dysfunction with Alda-1 are presented. Treatment of pulmonary endothelial cells subjected to hyperoxia with Alda-1 showed an increase in ALDH2 activity and expression. Treatment with Alda-1 also illustrated a decrease in oxidative stress, a decrease in reactive oxygen species (ROS), a decrease in apoptosis, a decrease in inflammation and an enhancement of mitochondrial membrane potential.
    Type: Application
    Filed: April 3, 2020
    Publication date: July 30, 2020
    Inventors: Narasaiah Kolliputi, Richard F. Lockey, Lakshmi Galam
  • ALDA-1 treatment and prevention of pulmonary disease
    Patent number: 10660873
    Abstract: Methods of treating or preventing allergic or pulmonary diseases characterized by endothelial dysfunction with Alda-1 are presented. Treatment of pulmonary endothelial cells subjected to hyperoxia with Alda-1 showed an increase in ALDH2 activity and expression. Treatment with Alda-1 also illustrated a decrease in oxidative stress, a decrease in reactive oxygen species (ROS), a decrease in apoptosis, a decrease in inflammation and an enhancement of mitochondrial membrane potential.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: May 26, 2020
    Assignee: University of South Florida
    Inventors: Narasaiah Kolliputi, Richard F. Lockey, Lakshmi Galam
  • ALDA-1 TREATMENT AND PREVENTION OF PULMONARY DISEASE
    Publication number: 20190262308
    Abstract: Method of treating or preventing allergic or pulmonary diseases characterized by endothelial dysfunction with Alda-1. Methods of treating or preventing endothelial dysfunction, and/or method of activating ALDH2 with Alda-1. Specifically, it was found that Alda-1 shields endothelial cells against oxidative stress via activation of ALDH2.
    Type: Application
    Filed: February 22, 2019
    Publication date: August 29, 2019
    Applicant: University of South Florida
    Inventors: Narasaiah Kolliputi, Richard F. Lockey, Lakshmi Galam