Patents by Inventor Narasimhaiah Sitaram

Narasimhaiah Sitaram has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indolicidin analogs with anti-microbial activity
    Patent number: 7115572
    Abstract: The present invention relates to three single tryptophan analogs ILPWKLPLLPLRR-amide (IL4) (SEQ ID NO: 1), ILPLKLPWLPLRR-amide (IL8) (SEQ ID NO: 2) and ILPLKLPLLPWRR-amide (IL11) (SEQ ID NO: 3), of Indolicidin, a cationic tridecapeptide amide found in the granules of bovine neutrophils, the analogs having the amino acid only at the 4th, 8th or 11th position from the N-terminal, with leucine at its all other conventional positions, the analogs selectively having only anti-microbial activity and no hemolytic activity of Indolicidin, and thereby providing therapeutic options and a method thereof.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: October 3, 2006
    Assignee: Council of Scientific and Industrial Research
    Inventors: Chilukuri Subbalakshmi, Eruguraia Bikshapathy, Narasimhaiah Sitaram, Ramakrishnan Nagaraj
  • Indolicidin analogs with anti-microbial activity
    Publication number: 20040176300
    Abstract: The present invention relates to three single tryptophan analogs ILPWKLPLLPLRR-amide (IL4), ILPLKLPWLPLRR-amide (IL8) and ILPLKLPLLPWRR-amide (IL11), of indolicidin, a cationic tridecapeptide amide found in the granules of bovine neutrophils, said analogs having said amino acid only at 4th, 8th or 11th position from N-terminal, with leucine at its all other conventional positions, said analogs selectively having only anti-microbial activity and no hemolytic activity of Indolicidin, and thereby providing therapeutic options and a method thereof.
    Type: Application
    Filed: March 25, 2002
    Publication date: September 9, 2004
    Applicant: Council of Scientific and Industrial Research
    Inventors: Chilukuri Subbalakshmi, E. Bikshapathy, Narasimhaiah Sitaram, Ramakrishnan Nagaraj
  • Diastereo analog of peptide SPFK-amide with selective anti-microbial activity and a method thereof
    Publication number: 20030186888
    Abstract: The present invention relates to a novel Diastereo analog Dsam of peptide SPFK-amide of amino acid sequence PKLLKTFLSKWIG with D-Leu residues at positions 4 and 8 of analog, having selective anti-microbial activity and no hemolytic activity of said SPFK, and a method of producing said Diastereo analog.
    Type: Application
    Filed: March 28, 2002
    Publication date: October 2, 2003
    Inventors: Chilukuri Subbalakshmi, Ramakrishnan Nagaraj, Narasimhaiah Sitaram