Patents by Inventor Narayana Rao Iyyalasomayazula

Narayana Rao Iyyalasomayazula has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-radioactive methods for chemical cleavage sequencing and footprinting of nucleic acids
    Patent number: 6165726
    Abstract: A method of sequencing a nucleic acid is provided, comprising: a) labeling the nucleic acid with biotin; b) subjecting the nucleic acid of step a) to base specific chemical modifications; c) cleaving the nucleic acid of step b) at the modified bases with hot piperidine; d) contacting the nucleic acid of step c) with immobilized streptavidin, whereby biotin-containing fragments are bound to immobilized streptavidin and unbound fragments are washed off; e) extracting the streptavidin bound fragments of step d); f) resolving the fragments of step e) on a denaturing polyacrylamide gel; and g) staining the fragments in the gel of step f) by silver staining.
    Type: Grant
    Filed: September 21, 1999
    Date of Patent: December 26, 2000
    Assignee: UT-Battelle, LLC
    Inventor: Narayana Rao Iyyalasomayazula