Abstract: A composition of matter comprising a synergistic formulation of plant extracts for hepatic and adrenal disorders is provided. In an implementation, an example extraction method for concentrating pharmacologically active fractions of plants provides a synergistically active compound containing approximately 5%-25% extract of Andrographis paniculata, approximately 10%-30% extract of Boerhavia diffusa, approximately 25%-50% extract of Phyllanthus niruri, and approximately 15%-40% extract of Tephrosia purpurea. The synergistically active compound provides greater therapeutic benefit than the individual ingredients alone, or the combined ingredients in different concentration ranges. The synergistic formulation may also be used for treatment of other medical conditions.