Abstract: A process for preparing perindopril is provided comprising condensing an N-[(S)-1-carbethoxybutyl]-(S)-alanyl halide of formula II: wherein X is a halide with an (2S,3aS,7aS)-2-carboxyperhydroindole of formula III: wherein R is hydrogen or a protecting group.

Abstract: Eprosartan mesylate substantially in an amorphous form is disclosed. A composition comprising eprosartan mesylate in a solid form, wherein at least about 80% by weight of the solid eprosartan mesylate is in an amorphous form is also disclosed. The present invention also provides a process for preparing eprosartan mesylate substantially in an amorphous form by providing a solution of eprosartan mesylate in one or more solvents capable of dissolving the eprosartan mesylate and substantially removing the solvent from the solution.

Abstract: Frovatriptan succinate substantially in an amorphous form is disclosed. Also disclosed is a composition comprising frovatriptan succinate in a solid form, wherein at least about 80% by weight of the solid is frovatriptan succinate in an amorphous form. The present invention also provides a process for preparing frovatriptan succinate substantially in an amorphous form by providing a solution of frovatriptan succinate in one or more solvents capable of dissolving the frovatriptan succinate and substantially removing the solvent from the solution.

Abstract: An improved process for the preparation of pyrimidine derivatives is provided comprising reacting a Wittig reagent of the general formula wherein R is an alkyl of from 1 to 10 carbon atoms, aryl or arylalkyl, R1 is a substituted or unsubstituted hydrocarbon group, R2 and R3 are the same or different and are hydrogen or a substituted or unsubstituted hydrocarbon group; Z is sulfur, oxygen, sulfonyl, or imino which may be substituted by formyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, amino substituted by sulfonyl or alkylsulfonyl, and sulfonyl substituted by alkyl, amino or alkylamino and X is a halogen; with an aldehyde of the general formula wherein R4 is hydrogen, a lower alkyl or a cation capable of forming a non-toxic pharmaceutically acceptable salt and each R5 are the same or different and are hydrogen or a hydrolyzable protecting group, or each R5, together with the oxygen atom to which each is bonded, form a hydrolyzable cyclic protecting group, or each R5 is bonded to the

Abstract: In accordance with one embodiment of the present invention, a catalyst system is provided. The catalyst system includes a catalyst bed that comprises a plurality of catalyst segments arranged such that an exhaust flow passes along a longitudinal axis of the catalyst system through the plurality of catalyst segments from a first one of the plurality of catalyst segments through a last one of the plurality of catalyst segments, each of the plurality of catalyst segments comprising a plurality of catalytic cells, wherein a concentration of catalytic material decreases from the first one of the plurality of catalyst segments through the last one of the plurality of catalyst segments.

Abstract: A method for operating a gas turbine engine, including a first compressor, a second compressor, a combustor and a turbine, coupled together in serial flow arrangement, and an intercooler coupled between the first compressor and the second compressor, the intercooler including a first heat exchanger and a second heat exchanger. The method includes channeling compressed airflow from the first compressor to the first heat exchanger, extracting energy from the compressed airflow using a first working fluid flowing through the first heat exchanger to facilitate reducing an operating temperature of the compressed airflow and to facilitate increasing an operating temperature of the first working fluid, and channeling the first working fluid to a process heat exchanger, and channel the compressed airflow form the first heat exchanger to the second compressor.

Abstract: A method for operating a gas turbine engine, including a first compressor, a second compressor, a combustor and a turbine, coupled together in serial flow arrangement, and an intercooler coupled between the first compressor and the second compressor, the intercooler including a first heat exchanger and a second heat exchanger. The method includes channeling compressed airflow from the first compressor to the first heat exchanger, extracting energy from the compressed airflow using a first working fluid flowing through the first heat exchanger to facilitate reducing an operating temperature of the compressed airflow and to facilitate increasing an operating temperature of the first working fluid, and channeling the first working fluid to a process heat exchanger, and channel the compressed airflow form the first heat exchanger to the second compressor.

Abstract: A method for assembling a gas turbine engine assembly includes providing a core gas turbine engine including a high-pressure compressor, a combustor, and a high-pressure turbine, and coupling a low-pressure compressor between the core gas turbine engine and a motor such that the low-pressure compressor is driven only by the motor.

Abstract: Mifepristone substantially in polymorph form M is provided. Also provided is a process for the preparation of polymorph form M of mifepristone comprising the steps of (a) dissolving crude mifepristone in a polar solvent at an elevated temperature to obtain a clear solution; (b) cooling the solution to a temperature and for a time period sufficient to form a precipitate of mifepristone crystals; and (c) isolating the precipitate of mifepristone crystals to obtain the polymorph form M of mifepristone.

Abstract: A method for operating a gas turbine engine including a compressor, a combustor, and a turbine, coupled together in serial flow arrangement, and a fuel system including a heat exchanger and an economizer. The method includes channeling fuel through the heat exchanger, channeling a working fluid through the the exchanger to facilitate regulating the operating temperature of the fuel and the operating temperature of the working fluid, and channeling the fuel and the working fluid into the gas turbine engine combustor to facilitate increasing a fuel efficiency of the gas turbine engine.

Abstract: A method for operating a power generation system including a wind turbine and a turbine assembly. The method includes operating the wind turbine, storing the energy generated by the wind turbine as compressed air, and channeling the compressed air to the turbine assembly when needed.

Abstract: A gas turbine engine system includes an intercooler coupled between a low-pressure compressor and a high-pressure compressor and configured to cool the compressed air exiting the low-pressure compressor. Liquid natural gas or a cooled intermediate working fluid is used in the intercooler to cool the compressed air exiting the low-pressure compressor. A mixture of fuel and compressed air from the high-pressure are combusted in a combustion chamber of an engine. A turbine is coupled to the engine and configured to expand combustion exhaust gas ejected from the engine to generate power. A heat exchanger is coupled to the turbine and the intercooler and configured to re-gasify the liquid natural gas. The exhaust air exiting the turbine or a heated intermediate working fluid is used to gasify the liquid natural gas in the heat exchanger.

Abstract: A process for the preparation of (2S, 3aS, 7aS)perhydroindole-2-carboxylic acid is provided comprising (a) esterifying a cis-perhydroindole-2-carboxylic acid with a first alcohol of the formula ROH and a suitable free acid to provide the acid salt (AS) of Formula V: (b) reacting the acid salt of Formula V with a first base to provide a compound of Formula VI: (c) treating the product of step (b) with an L-tartaric containing acid in a second alcohol of the formula ROH to precipitate a compound of Formula VII: (d) reacting the compound of Formula VII with a second base to provide a compound of Formula II (e) hydrolyzing the compound of Formula II to provide the (2S, 3aS, 7aS)perhydroindole-2-carboxylic acid.

Abstract: A method for supplying power to a remote load includes coupling a gas turbine engine to a vessel that is not used to provide propulsion for the vessel, coupling a generator to the gas turbine engine, coupling an intercooler system downstream from a first compressor such that compressed air discharged from the first compressor is channeled therethrough, the intercooler system includes an intercooler and a first heat exchanger, channeling a first working fluid through the intercooler to facilitate reducing an operating temperature of air discharged from the intercooler to a second compressor, channeling a second working fluid flowing through the first heat exchanger to extract energy from the first working fluid to facilitate reducing an operating temperature of the first working fluid, and operating the gas turbine engine and generator to supply power to a load that is located remotely from the vessel.

Abstract: A process for preparing perindopril is provided comprising condensing an N-[(S)-1-carbethoxybutyl]-(S)-alanyl halide of formula II: wherein X is a halide with an (2S,3aS,7aS)-2-carboxyperhydroindole of formula III: wherein R is hydrogen or a protecting group.

Abstract: A process for the preparation of a biphenyl-containing compound of general formula I: wherein R1 is a C3-6 carbonyl containing compound; R2 is a substituted or unsubstituted, straight or branched C3-6 alkyl group, or R1 and R2 together with the nitrogen atom to which they are bonded are joined together to form a substituted heterocyclic group selected from the group consisting of substituted or unsubstituted imidazoles, substituted or unsubstituted benzimidazoles and substituted or unsubstituted 1,3-diazaspiro[4,4]non-1-en-4-one; and R3 is a carboxylic acid ester, cyano, a substituted or unsubstituted 1H-tetrazolyl group or a substituted or unsubstituted group which may be converted in vivo into a carboxy group is provided, the process comprising reacting a compound of general formula II: wherein R1 and R2 have the aforestated meanings with a compound of general formula III: wherein Z is a leaving group and R3 has the aforestated meaning in a biphasic solvent system in the presence of a phase tra

Abstract: A process for the preparation of anastrozole is provided, the process comprising: (a) reacting 3,5-bis(1-cyano-1-methylethyl)benzyl halide with a 4-Z-1,2,4-triazole compound of the formula wherein Z is a protecting group to produce 2,2?-[5-(4-Z-1,2,4-triazolium-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile) halide; and (b) deprotecting the 2,2?-[5-(4-Z-1,2,4-triazolium-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile)halide to produce anastrozole. Also provided is anastrozole substantially free of its isomers.

Abstract: A process for the preparation of an intermediate of trandolapril, (2S,3aR,7aS)-perhydroindole-2-carboxylic acid of Formula II is provided. Also provided are processes for preparing trandolapril.

Abstract: A method for operating a gas turbine engine including a compressor, combustor, and turbine is provided that includes channeling compressed airflow from the compressor to a heat exchanger having a working fluid circulating within, channeling the working fluid from the heat exchanger to a chiller, extracting energy from the working fluid to power the chiller, and directing airflow entering the gas turbine engine through the inlet chiller such that the temperature of the airflow is reduced prior to the airflow entering the compressor.

Abstract: A method for operating a gas turbine engine includes channeling compressed airflow discharged from a first compressor through an intercooler having a cooling medium flowing therethrough, channeling a working fluid through the intercooler to facilitate increasing an operating temperature of the working fluid, and channeling the discharged working fluid to a combustor to facilitate increasing an operating efficiency of the gas turbine engine.