Abstract: A filter assembly comprises a housing defining an internal volume. The housing defines an outlet. A housing ledge extends radially inwards from a rim of the outlet. An outlet conduit comprises an outlet elbow, and an outlet tube extending axially from the outlet elbow towards the housing. The outlet tube is positioned within the housing. A rib extends radially from an outer surface of the outlet tube proximate to the outlet elbow. The rib engages the housing ledge so as to couple the outlet conduit to the housing. A filter element is also positioned within the housing.

Abstract: An air cleaner assembly comprises a filter element and a housing assembly. The filter element comprises a filter media for filtering a fluid and a first endcap positioned along a first end of the filter media and through which a first filtered air flow portion flows. The housing assembly at least partially contains the filter element and comprises a cover that defines a first outlet through which the first filtered air flow portion flows to a downstream device. The cover comprises a noise reduction device that receives the first filtered air flow portion and dissipates sound waves traveling upstream from the downstream device.

Abstract: Various example embodiments relate to a filtration system. The filtration system includes a filter housing having a first housing end and a second housing end. The filter housing includes a housing cover defining an outlet. The housing cover includes a first guidance element extending from an internal portion of the housing cover axially away from the outlet. A second guidance element extends from the internal portion of the housing cover axially away from the outlet. A filter element has a first filter end and a second filter end. The filter element includes an end cap adjacent the first filter end and defining an end cap opening therethrough. The end cap includes a channel around the end cap opening. Filter media has a first media end and a second media end. The filter media extends axially from the first media end toward the second media end.

Abstract: Various example embodiments relate to a filtration system. The filtration system includes a filter housing having a first housing end and a second housing end. The filter housing includes a housing cover defining an outlet. The housing cover includes a first guidance element extending from an internal portion of the housing cover axially away from the outlet. A second guidance element extends from the internal portion of the housing cover axially away from the outlet. A filter element has a first filter end and a second filter end. The filter element includes an end cap adjacent the first filter end and defining an end cap opening therethrough. The end cap includes a channel around the end cap opening. Filter media has a first media end and a second media end. The filter media extends axially from the first media end toward the second media end.

Abstract: A filter assembly comprises a housing defining an internal volume. The housing defines an outlet. A housing ledge extends radially inwards from a rim of the outlet. An outlet conduit comprises an outlet elbow, and an outlet tube extending axially from the outlet elbow towards the housing. The outlet tube is positioned within the housing. A rib extends radially from an outer surface of the outlet tube proximate to the outlet elbow. The rib engages the housing ledge so as to couple the outlet conduit to the housing. A filter element is also positioned within the housing.

Abstract: The invention relates to improved method of synthesis for Treprostinil comprising condensation reaction of the carbonyl compound having allyl, alkyl, crotyl or MEM-protected phenolic hydroxyl group, compound (4) with a hydroxyl-protected alkynol (5) to give the condensation product, compound (6). Subjecting compound (6) to oxidation, reduction, hydroxyl protection and carbonylation, cyclization reactions gave the tricyclic derivative (10). Further reactions comprising reduction, hydrogenation and deprotection of the phenolic and side-chain hydroxyl groups, wherein the sequence and choice of reagents was governed by protecting groups, gave the triol intermediate, compound (14). Cyanoalkylation at phenolic hydroxyl functionality and further hydrolysis yielded the prostacyclin compound, Treprostinil (1) and its pharmaceutically acceptable salts, having desired purity.

Abstract: The invention relates to an improved method for a 5+3+2 solution phase syntheses of Icatibant acetate (1) comprising coupling of suitably protected peptide fragments which on deprotection followed by treatment with acetic acid provide Icatibant acetate (1) having desired purity.

Abstract: The invention relates to improved method of synthesis for Treprostinil comprising condensation reaction of the carbonyl compound having allyl, alkyl, crotyl or MEM-protected phenolic hydroxyl group, compound (4) with a hydroxyl-protected alkynol (5) to give the condensation product, compound (6). Subjecting compound (6) to oxidation, reduction, hydroxyl protection and carbonylation, cyclization reactions gave the tricyclic derivative (10). Further reactions comprising reduction, hydrogenation and deprotection of the phenolic and side-chain hydroxyl groups, wherein the sequence and choice of reagents was governed by protecting groups, gave the triol intermediate, compound (14). Cyanoalkylation at phenolic hydroxyl functionality and further hydrolysis yielded the prostacyclin compound, Treprostinil (1) and its pharmaceutically acceptable salts, having desired purity.

Abstract: The present invention relates to the preparation of stable pyridone disulphide derivatives having general formula (I) and its stereoisomers, which are useful in the treatment of gastrointestinal disorders. Pyridone disulphide derivatives (I) wherein, R1, R2 and R3 are independently alkyl, alkoxy, halogen, halogenated alkoxy, halogenated alkyl, hydrogen and could be the same or different and X is CH or N. R1 is methyl, methoxy, fluorine, trifluoromethyl, difluoromethoxy and hydrogen, R2 is methyl, methoxy and hydrogen, and R3 is methyl and hydrogen.

Abstract: The present invention relates to the preparation of stable pyridone disulphide derivatives having general formula (I) and its stereoisomers, which are useful in the treatment of gastrointestinal disorders. Pyridone disulphide derivatives (I) wherein, R1, R2 and R3 are independently alkyl, alkoxy, halogen, halogenated alkoxy, halogenated alkyl, hydrogen and could be the same or different and X is CH or N. R1 is methyl, methoxy, fluorine, trifluoromethyl, difluoromethoxy and hydrogen, R2 is methyl, methoxy and hydrogen, and R3 is methyl and hydrogen.

Abstract: The present invention relates to the preparation of stable pyridone disulphide derivatives having general formula (I) and its stereoisomers, which are useful in the treatment of gastrointestinal disorders. Pyridone disulphide derivatives (I) wherein, R1, R2 and R3 are independently alkyl, alkoxy, halogen, halogenated alkoxy, halogenated alkyl, hydrogen and could be the same or different and X is CH or N. R1 is methyl, methoxy, fluorine, trifluoromethyl, difluoromethoxy and hydrogen, R2 is methyl, methoxy and hydrogen, and R3 is methyl and hydrogen.

Abstract: The present invention relates to the preparation of stable pyridone disulphide derivatives having general formula (I) and its stereoisomers, which are useful in the treatment of gastrointestinal disorders. Pyridone disulphide derivatives (I) wherein, R1, R2 and R3 are independently alkyl, alkoxy, halogen, halogenated alkoxy, halogenated alkyl, hydrogen and could be the same or different and X is CH or N. R1 is methyl, methoxy, fluorine, trifluoromethyl, difluoromethoxy and hydrogen, R2 is methyl, methoxy and hydrogen, and R3 is methyl and hydrogen.

Abstract: The present invention provides a simple and efficient method for synthesis of 4-[bis(2-chloroethyl)-amino]-L-phenylalanine hydrochloride. The process involves the treatment of 4-[bis(2-chloroethyl)-amino]-L-phenylalanine free base with hydrochloric acid in water followed by isolation of 4-[bis(2-chloroethyl)-amino]-L-phenylalanine hydrochloride of desired purity.

Abstract: The present invention provides a simple method for preparation of benzphetamine and its acid addition salt comprising reaction of methamphetamine hydrochloride of formula (III) with benzyl chloride and treating the isolated benzphetamine of formula (II) with an acid dissolved in an organic solvent to provide benzphetamine acid addition salt, more specifically, benzphetamine hydrochloride of formula (I).

Abstract: The present invention provides a simple and efficient method for synthesis of 4-[bis (2-chloroethyl)-amino]-L-phenylalanine hydrochloride. The process involves the treatment of 4-[bis(2-chloroethyl)-amino]-L-phenylalanine free base with hydrochloric acid in water followed by isolation of 4-[bis(2-chloroethyl)-amino]-phenylalanine hydrochloride of desired purity.