Abstract: A multiphase switching converter includes: a plurality of phases, each phase including a current detection device, a set of switching devices, an output capacitor coupled to each phase of the plurality of phases, and a control circuit. The current detection device of each phase of the plurality of phases is configured to receive an error current from the control circuit and generate a corresponding signal to control a duty cycle of a set of corresponding switching devices such that each phase delivers a substantially equal quantity of charge to the corresponding output capacitor to maintain a charge balance on the corresponding output capacitor.

Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.

Abstract: An electronic circuit is disclosed. The electronic circuit includes a switching circuit that includes a high side switch connected to a low side switch at a switch node, a controller arranged to generate a high side control signal and a low side control signal, a variable delay circuit arranged to receive the high side control signal and in response transmit a corresponding delayed high side control signal, and to receive the low side control signal and in response transmit a corresponding delayed low side control signal, a high side driver circuit arranged to transmit a high side drive signal to the high side switch in response to receiving the delayed high side control signal, and a low side driver circuit arranged to transmit a low side drive signal to the low side switch in response to receiving the delayed low side control signal.

Abstract: A multiphase switching converter includes: a plurality of phases, each phase including a current detection device, a set of switching devices, an output capacitor coupled to each phase of the plurality of phases, and a control circuit. The current detection device of each phase of the plurality of phases is configured to receive an error current from the control circuit and generate a corresponding signal to control a duty cycle of a set of corresponding switching devices such that each phase delivers a substantially equal quantity of charge to the corresponding output capacitor to maintain a charge balance on the corresponding output capacitor.

Abstract: Provided herein are methods and compositions for treating a coagulopathy in a subject. Such methods can include administering to the subject in need thereof, for example because they have been administered an anticoagulant agent, an effective amount of a composition including platelets, or in illustrative embodiments platelet derivatives, and in further illustrative embodiments freeze-dried platelet derivatives (FDPDs). Various properties of exemplary embodiments of such methods and platelet derivatives used therein, as well as numerous additional aspects and embodiments are provided herein.

Abstract: A multiphase switching voltage regulator is disclosed. The regulator includes a first clock generator circuit configured to receive a reference clock, and to generate M first clocks, where the M first clocks are phase separated by 360°/M, a plurality of phase extrapolator circuits, where the plurality of phase extrapolator circuits includes N phase extrapolator circuits, and a phase selector multiplexer configured to provide one of the M first clocks to each of the phase extrapolator circuits, where the N phase extrapolator circuits are configured to generate N output clocks, where the N output clocks are phase separated by 360°/N.

Abstract: An electronic circuit is disclosed. The electronic circuit includes a switching circuit that includes a high side switch connected to a low side switch at a switch node, a controller arranged to generate a high side control signal and a low side control signal, a variable delay circuit arranged to receive the high side control signal and in response transmit a corresponding delayed high side control signal, and to receive the low side control signal and in response transmit a corresponding delayed low side control signal, a high side driver circuit arranged to transmit a high side drive signal to the high side switch in response to receiving the delayed high side control signal, and a low side driver circuit arranged to transmit a low side drive signal to the low side switch in response to receiving the delayed low side control signal.

Abstract: A voltage regulator circuit is disclosed. The voltage regulator circuit includes a level shifter circuit. The level shifter circuit includes first and second nodes that each switch between a first low voltage and a first high voltage, third and fourth nodes that each switch between a second low voltage and a second high voltage, where the second high voltage is different from the first high voltage. The level shifter circuit also includes a DC path circuit connected between the first and third nodes, and arranged to selectively conduct a current between the first and third nodes.

Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.

Abstract: A multiphase switching voltage regulator is disclosed. The regulator includes a first clock generator circuit configured to receive a reference clock, and to generate M first clocks, where the M first clocks are phase separated by 360°/M, a plurality of phase extrapolator circuits, where the plurality of phase extrapolator circuits includes N phase extrapolator circuits, and a phase selector multiplexer configured to provide one of the M first clocks to each of the phase extrapolator circuits, where the N phase extrapolator circuits are configured to generate N output clocks, where the N output clocks are phase separated by 360°/N.

Abstract: An integrated circuit device includes: an input stage configured to receive first and a second input signals and generate a first voltage based on the first input signal and generate a second voltage based on the second input signal; an amplification stage configured to generate a first output current based on the first voltage and a second output current based on the second voltage; a bias stage configured to generate a bias voltage for the amplification stage based on the first and second voltages; a load stage configured to output a differential voltage signal proportional to a current through a device for which current is sensed based on a comparison of the first and second output currents; and an output stage configured to output a signal to control a duty cycle of the device for which current is sensed.

Abstract: A method, computer system, and a computer program product for data labeling is provided. The present invention may include receiving a plurality of labeled data points. The present invention may include identifying one or more of the plurality of labeled data points with conflicting labels. The present invention may include determining that at least one of the one or more identified labeled data points exceeds one or more conflict thresholds. The present invention may include presenting the at least one or more identified labeled data points exceeding one or more conflict thresholds to a user. The present invention may include receiving a conflict resolution from the user for the one or more identified labeled data points exceeding the one or more conflict thresholds.

Abstract: A multiphase switching converter includes: a plurality of phases, an output capacitor, and a control loop. Each phase includes: a current detection device, a pulse width modulator, a set of switching devices, and an inductor. The control loop is configured to generate a first current signal to the current detection device of each phase of the plurality of phases. The first current signal is proportional to an average current generated by the plurality of phases. The current detection device of each phase provides a signal to a corresponding PWM to control a duty cycle of the set of switching devices to equalize the current generated by each phase and maintain a charge balance on the output capacitor.

Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.

Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.

Abstract: Provided herein are methods and compositions for treating a coagulopathy in a subject. Such methods can include administering to the subject in need thereof, for example because they have been administered an anticoagulant agent, an effective amount of a composition including platelets, or in illustrative embodiments platelet derivatives, and in further illustrative embodiments freeze-dried platelet derivatives (FDPDs). Various properties of exemplary embodiments of such methods and platelet derivatives used therein, as well as numerous additional aspects and embodiments are provided herein.

Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject that is being administered or has been administered an antiplatelet agent, the method comprising: (a) determining that the subject has an abnormal result for evaluation of one or more clotting parameters; and (b) after (a), administering to the subject in need thereof an effective amount of a composition comprising platelets or platelet derivatives and an incubating agent comprising one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent.

Abstract: Provided herein are methods and compositions for treating acquired hemophilia with platelets and/or platelet derivatives. In some cases, the platelets and or platelet derivatives are loaded with an anti-fibrinolytic.

Abstract: Provided herein are methods and compositions for treating congenital hemophilia with platelets and/or platelet derivatives. In some cases, the platelets and or platelet derivatives are loaded with an anti-fibrinolytic.

Abstract: Embodiments disclosed herein can leverage dynamic data, fields and implied information from online media (e.g., web sites, mobile apps and other forms of online media such as virtual or augmented reality environments) to create a universal variable map and automatically generate deep-linked ads utilizing the universal variable map, linking any arbitrary online media to any other arbitrary online media. The automatically generated deep-linked ads can be inserted into any ad server and served out from there in real-time. A deep-linked ad thus presented to a user can take the user from a starting page on one site or application where the ad is displayed directly to a resulting page such as a checkout page on another site or mobile application, with pertinent information already pre-populated, and action already initiated for the user.