Abstract: A method of extracting and detecting paramagnetic material in an aqueous medium, the method including: loading a sample into a holder in a cavity enhancement module; directing light from a light source to the sample in the holder; applying an oscillating magnetic field to the sample in the holder; determining a first level of transmittance with the oscillating magnetic field in a first state; determining a second level of transmittance with the oscillating magnetic field in the second state; and determining a change in transmittance of the light from the sample based on the first level of transmittance and the second level of transmittance.

Abstract: An apparatus is disclosed for separating and preserving biomolecules of a biological fluid sample.

Abstract: An applicator includes a body defining a cavity configured to receive a container, a nozzle at an upper portion of the body, the nozzle comprising, an outer nozzle portion having a circular shape and defining a plurality of overflow channels, an inner nozzle portion having a circular shape and spaced from the outer nozzle portion by a circular channel, the inner nozzle portion including a ridge around a periphery of the inner nozzle portion and a cleft defining the ridge, the cleft and the ridge each having circular shapes, and a plurality of connectors extending through the channel and connecting the inner nozzle portion to the outer nozzle portion, wherein the overflow channels extend radially outward from the channel, and a plunger including a shaft and a base, the shaft being movable within the cavity and configured to guide the container toward the nozzle.

Abstract: The present invention is directed to a method and apparatus that involves improved characterization of an object based on its surface roughness and other unique features without having to necessarily define a fixed and predetermined region of interest. In accordance with one aspect, the present invention provides a method for characterizing an object based on a pattern of the object's surface roughness. The method comprises the steps of obtaining a unique image of a feature on the surface of the object, converting the image obtained into certain electrical signals and processing the electrical signals so they are associated with the object and thereby provide a characterization of the object that is used to generate a unique identifying signature for the object.

Abstract: An apparatus is disclosed for separating and preserving biomolecules of a biological fluid sample.

Abstract: The apparatus of the present invention comprises an integrated membrane for separation and preservation of biomolecules. Biomolecules, such as those in blood, can be separated and preserved. The apparatus includes a housing having a matrix portion, and a fluid collection portion disposed within an inner cavity. The housing further includes an aperture permitting access to the inner cavity. The apparatus also includes a matrix disposed within the matrix portion. The matrix includes a first layer for collecting cells from the fluid, a second layer for protein adsorption, and a third layer for nucleic acid adsorption. Fluid enters the housing through the aperture, passes through the matrix, and into the fluid collection portion. Cells from the fluid in a layer of the matrix are collected; adsorbing protein from the fluid in a layer of the matrix; and adsorbing nucleic acid from the fluid in a layer of the matrix.

Abstract: The present invention is directed to a method and apparatus that involves improved characterization of an object based on its surface roughness and other unique features without having to necessarily define a fixed and predetermined region of interest. In accordance with one aspect, the present invention provides a method for characterizing an object based on a pattern of the object's surface roughness. The method comprises the steps of obtaining a unique image of a feature on the surface of the object, converting the image obtained into certain electrical signals and processing the electrical signals so they are associated with the object and thereby provide a characterization of the object that is used to generate a unique identifying signature for the object.

Abstract: The present invention is directed to a method and apparatus that involves improved characterization of an object based on its surface roughness and other unique features without having to necessarily define a fixed and predetermined region of interest. In accordance with one aspect, the present invention provides a method for characterizing an object based on a pattern of the object's surface roughness. The method comprises the steps of obtaining a unique image of a feature on the surface of the object, converting the image obtained into certain electrical signals and processing the electrical signals so they are associated with the object and thereby provide a characterization of the object that is used to generate a unique identifying signature for the object.

Abstract: A blood fractionating apparatus that enables aseptic fractionation and storing of fractionated blood components, comprises a centrifuge tube including three chambers separated by constricted sealable passages, an open operative upper end chamber, a closed operative lower end chamber and a middle chamber defined between the upper end chamber and the lower end chamber and connected by means of the sealable passages. A stopper with a flapper valve is provided at the opening of the upper end chamber to control flow of fluid to and from the chambers. This apparatus enables separating the chambers to obtain a hermetically sealed operative lower chamber containing the corpuscle component and a hermetically sealed middle chamber containing the plasma component that can be stored at ambient temperature.

Abstract: A device for measuring an analyte concentration level in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light.

Abstract: A device for measuring a hydration status based on an analyte concentration in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light, wherein the processor determines a hydration status of the subject based on the analyte concentration level and reference data.

Abstract: A device for measuring an analyte concentration level in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light.

Abstract: In one embodiment, a system for determining information about an assay incorporates a filter assembly that includes an optical structure configured to be removably attachable to a laser resonating cavity of the system, the optical structure being configured to form a portion of the laser resonating cavity such that it reflects light propagating through a gain medium in the laser resonating cavity when attached thereto. The optical structure can include a first surface having an array of one or more sites, each site containing an assay, and a second surface configured such that the second surface is disposed within the laser resonating cavity forming a portion of the laser resonating cavity. The optical structure is configured to optically interact with the assay to change one or more characteristics of light in the laser resonating cavity based on a reaction that occurs in an assay on said first surface.

Abstract: A device for measuring a hydration status based on an analyte concentration in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light, wherein the processor determines a hydration status of the subject based on the analyte concentration level and reference data.

Abstract: A device for measuring an analyte concentration level in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light.

Abstract: In one embodiment, a system for determining information about an assay incorporates a filter assembly that includes an optical structure configured to be removably attachable to a laser resonating cavity of the system, the optical structure being configured to form a portion of the laser resonating cavity such that it reflects light propagating through a gain medium in the laser resonating cavity when attached thereto. The optical structure can include a first surface having an array of one or more sites, each site containing an assay, and a second surface configured such that the second surface is disposed within the laser resonating cavity forming a portion of the laser resonating cavity. The optical structure is configured to optically interact with the assay to change one or more characteristics of light in the laser resonating cavity based on a reaction that occurs in an assay on said first surface.

Abstract: A system and method for determining information about an assay. In one embodiment the method includes positioning a filter assembly, having an assay disposed on its surface, relative to a light source such that light from the light source is incident on the filter assembly and at least a portion of the light incident on the filter assembly is reflected from the filter assembly, illuminating the filter assembly with light from the light source, receiving light reflected from the filter assembly in an optical element, analyzing one or more characteristics of the light received in the optical element to determine information about a reaction in the assay, wherein a reaction in the assay results in a change of one or more characteristics of the light received from the filter assembly.

Abstract: A system and method for determining information about an assay. In one embodiment the method includes positioning a filter assembly, having an assay disposed on its surface, relative to a light source such that light from the light source is incident on the filter assembly and at least a portion of the light incident on the filter assembly is reflected from the filter assembly, illuminating the filter assembly with light from the light source, receiving light reflected from the filter assembly in an optical element, analyzing one or more characteristics of the light received in the optical element to determine information about a reaction in the assay, wherein a reaction in the assay results in a change of one or more characteristics of the light received from the filter assembly.

Abstract: A controller for an optical amplifier and a method for controlling an optical amplifier are disclosed. The illustrative method includes inputting a set-point to a controller; receiving a portion of an input signal; receiving a portion of an output signal from a first amplifier stage; receiving a portion of an output signal from an attenuation stage; receiving a portion of an output signal from a second amplifier stage and adjusting the first amplifier stage, the second amplifier stage and the attenuation stage based on the received portions to substantially maintain the set-point.

Abstract: A dynamic controller for a multi-channel EDFA-type optical amplifier is provided that is capable of providing a substantially tilt-free output over a range of selectable gain set points. The dynamic controller includes a variable optical attenuator coupled between the two amplification coils of the EDFA amplifier, and a control circuit that instructs the attenuator of an amount that each channel should be attenuated to achieve a tilt-free output at a selected gain point. The controller further includes a gain controller and a tilt controller connected to the control circuit of the variable optical attenuator for providing signals indicative of an average amount of per channel attenuation and a relative amount of per channel attenuation necessary to achieve a selected gain set point while reducing or eliminating tilt, respectively.