Abstract: A system and method is provided for automatically detecting and marking a region of interest in a medical image. A region of interest is first identified in the medical image, such as a nipple of a breast region in a mammography image. The identified nipple is then marked with a digital indicator, such as a bright circle, so that a user viewing the image can easily identify the nipple. The digital indicator can be temporarily removed so that no portion of the region of interest is obscured by the digital indicator. A region of interest corresponding to another anatomical feature may also be marked, such as a pectoral muscle, which may be marked by placing a digital outline around the border of the pectoral muscle. A user viewing the medical image with the digital indicators can easily identify the marked regions of interest.