Abstract: In a seamless capsule manufacturing apparatus that ejects a droplet from a nozzle into hardening liquid to manufacture a seamless capsule SC, tube passages which are synthetic resin tubes are provided as flexible sections between pumps and the nozzle. The vibration caused by the pumps is absorbed in the flexible sections and thus is not transmitted to the nozzle, whereby eyes or the like of the seamless capsule caused by vibration noises can be suppressed. Instead of a synthetic resin tube, a vibration absorbing block formed of an elastic member may be attached to the tube passages. Alternatively, a vibration absorbing unit, which is provided with a pad formed of an elastic member and for holding the tube passages, may be provided.

Abstract: Processing vessel (1) is formed by overlaying a filter casing (2), a spray casing (3), a material container (4) and an air supply unit (5). Airtightnesses between respective units are maintained by airtight junctions (61 to 63). In the airtight junction (61), two seal portions (91 and 92) are radially provided, and U-seals (64 and 65) are contained. The U-seals (64 and 65) vertically move within seal grooves (67 and 68) through supply and exhaust of air to/from cylinder chambers (69 and 71), to thereby attain close contact with or detachment from flange (74). During particulate material processing, the airtightness of the seal portion (91) is maintained by the U-seal (64). During processing vessel washing, the airtightness of the seal portion (92) is maintained by the U-seal (65), to thereby prevent exposure thereof. Simultaneously, the U-seal (64) is raised, to thereby attain washing of the seal portion (S1) during the particulate processing.

Abstract: In a seamless capsule manufacturing apparatus that ejects a droplet (25) from a nozzle (7) into hardening liquid (10) to manufacture a seamless capsule SC, tube passages (6, 9) which are synthetic resin tubes are provided as flexible sections (16) between pumps (5, 8) and the nozzle (7). The vibration caused by the pumps (5, 8) is absorbed in the flexible sections (16) and thus is not transmitted to the nozzle (7), whereby eyes or the like of the seamless capsule caused by vibration noises can be suppressed. Instead of a synthetic resin tube, a vibration absorbing block formed of an elastic member may be attached to the tube passages (6, 9). Alternatively, a vibration absorbing unit, which is provided with a pad formed of an elastic member and for holding the tube passages (6, 9), may be provided.

Abstract: A cartridge filter 7 is vertically movably placed in a processing vessel 1 having a cylindrical profile. An ultrasonic washer 55 is fitted to the lateral wall 3a of the spray casing of the processing vessel 1. Washing liquid 56 is injected into the processing vessel 1 and the filter 7 is moved downward and immersed in the washing liquid 56. The washer 55 is activated under this condition to wash the filter 7. Since the washer 55 is arranged near the filter 7, the ultrasonic oscillation is easily transmitted to the filter 7 to efficiently remove the foreign objects adhering to the filter 7. Thus, with this arrangement, it is possible to wash the filter 7 in the processing vessel 1 without removing the filter 7 from a fluidized bed apparatus. In a filter washing apparatus 101, a cartridge filter 103 is contained in a processing vessel 102 and immersed in washing liquid 110.

Abstract: A rotating drum 3 has ventilation sections 6 that can ventilate the inside of the drum and the outside of the drum in the coating processing. To the ventilation sections 6, a panel unit 41 having arranged therein plural hollow pipes 42 through which cold water passes is attached. The hollow pipes 42 are fixed to a base plate 44 in parallel with each other, and a gap “G” is provided between the adjacent pipes. The base plate 44 is provided with a communication hole 45, and the hollow pipes 42 are so arranged as to face the communication hole 45. To both ends of the hollow pipes 42, charge/discharge collecting pipes 46a and 46b are fixed. In the coating processing, cold water is arbitrarily supplied to the hollow pipes 42 through the charge/discharge collecting pipe 46a to cool the drum 3 so as to bring about the temperature difference between the inside of the drum and processing objects, which can prevent coating base materials from adhering to the inside of the drum.

Abstract: A seamless capsule manufacturing device comprises a multiple nozzle 7 for ejecting liquid drops into hardening liquid 10 and a flow passage tube 11 for containing hardening liquid 10. The flow passage tube 11 has a deformation section 28 that includes an inlet part 25 and a formation tube part 28b showing a cross sectional area smaller than the inlet part 25. The liquid drops ejected from the multiple nozzle 7 into the hardening liquid 10 are once made to become spherical liquid drops 26 in a sol state at the inlet part 25. The liquid drops 26b are introduced from the inlet part 25 into the deformation section 28 while they are still in a sol state. As hardening liquid 10 is introduced from the inlet part 25 into the formation tube part 28b, its flow rate is changed and the liquid drops 26 are deformed due to the change in the flow rate to produce nonspherical seamless capsules SC.

Abstract: Under the granulating section 10a for performing fluidized-bed granulation coating of powder grains, a drying section 20a for drying powder grains granulated is provided. A drying section 30a for drying the powder grains that are not sufficiently dried is provided under the drying section 20a. A product discharging section 40a for discharging a dried product is provided under the drying section 30a. A fluidized-bed forming-gas is supplied downward to upward, and granulation and dryness are continuously performed by the fluidized-bed forming-gas, and the powder grains moved from the granulating section to the drying section located immediately thereunder are pneumatic classified.

Abstract: An upper processing section 10 is provided by evenly spacing out functional stations 13 having respective functions of steps constituting a fluidized bed granulation coating process, on circumferential points. An intermediate storing section 20 is provided under the upper processing section 10 by evenly spacing out powder grain storing vessels 22 corresponding to the plurality of functional stations 13, on circumferential points. A lower gas supply section 30 is provided under the intermediate storing section 20 by evenly spacing out gas supply stations 31 corresponding to the plurality of powder grain storing vessels 22. The powder grain storing vessels 22 storing powder grains sequentially proceed to the respective functional stations 13 to execute respective processes to the powder grains, and thereby granulation coating of the powder grains is performed in a batch type and a continuous type.

Abstract: Under the granulating section 10a for performing fluidized-bed granulation coating of powder grains, a drying section 20a for drying powder grains granulated is provided. A drying section 30a for drying the powder grains that are not sufficiently dried is provided under the drying section 20a. A product discharging section 40a for discharging a dried product is provided under the drying section 30a. A fluidized-bed forming-gas is supplied downward to upward, and granulation and dryness are continuously performed by the fluidized-bed forming-gas, and the powder grains moved from the granulating section to the drying section located immediately thereunder are pneumatic classified.

Abstract: An upper processing section 10 is provided by evenly spacing out functional stations 13 having respective functions of steps constituting a fluidized bed granulation coating process, on circumferential points. An intermediate storing section 20 is provided under the upper processing section 10 by evenly spacing out powder grain storing vessels 22 corresponding to the plurality of functional stations 13, on circumferential points. A lower gas supply section 30 is provided under the intermediate storing section 20 by evenly spacing out gas supply stations 31 corresponding to the plurality of powder grain storing vessels 22. The powder grain storing vessels 22 storing powder grains sequentially proceed to the respective functional stations 13 to execute respective processes to the powder grains, and thereby granulation coating of the powder grains is performed in a batch type and a continuous type.

Abstract: A powder grain processing apparatus is provided such that both agitation and mixture of powder grains can be performed efficiently.

Abstract: In a particle measurement device 1 for a powder or granular material processing apparatus, powder or granular material is introduced into a drawing tube 3, which is formed to be projected from the inside of the granulating vessel 2, by injecting high pressure gas from the inside of the granulating vessel 2, so as to capture it with adhesive film 6. The captured powder or granular material is photographed, and, based on the obtained image information, information on the powder or granular material within the granulating vessel 2 is obtained. An air inlet 4, which is communicated with the drawing tube 3, is provided in the drawing tube 3 in the neighborhood of its end portion 3b on the side of the outside of the granulating vessel 2. Through this air inlet 4, gas having higher pressure than the inside of the granulating vessel 2 is introduced into the drawing tube 3.

Abstract: A centrifugal tumbling granulating-coating apparatus for spherically granulating and coating pharmaceuticals, foods and the like. The apparatus is constructed such that an annular outer portion 5b of a rotary disc 5 is formed to provide an inclined portion which is inclined downwardly toward the center, the size (P) of the outer portion 5b in the horizontal direction is within the range of P.gtoreq.0.25D to the diameter (D) and preferably 0.4D.gtoreq.P.gtoreq.0.25D, and the height (H) is within the range of 0.1D.ltoreq.H.ltoreq.0.33D and preferably 0.1D.ltoreq.H.ltoreq.0.25D.

Abstract: A centrifugal tumbling granulating-coating apparatus has a rotary disk rotated in the horizontal direction and a stator provided at an outer peripheral position of the rotary disk at a predetermined internal from the rotary disk. The rotary disk is formed therein with a peripheral edge portion having a circularly arcuate-shaped vertical cross-section erected from a flat bottom surface portion and curved upwardly. In the rotary disk, a height (H) from the bottom surface portion to an outer peripheral end is set at a value within a range of 0.30R.ltoreq.H.ltoreq.R to a radius of curvature (R) of the peripheral edge portion, a width (W) of the peripheral edge portion is set at a value within a range of 0.07D.ltoreq.W.ltoreq.0.25D to a diameter (D) of the rotary disk and the radius of curvature (R) of the peripheral edge portion is set at a value within a range of 0.10D.ltoreq.R.ltoreq.0.25D to the diameter (D). A powder contact portion of the stator is formed substantially vertically.

Abstract: The rotary drum has a cylindrical portion (tubular body portion) formed therein with vent holes. An annular duct is disposed at the outside of the cylindrical portion of the rotary drum in a manner to surround the cylindrical portion. This annular duct is provided with a gas supply duct and an exhaust duct. In the annular duct, partition walls define a vent path, in which the drying gas which has been supplied from the gas supply duct flows through an accumulated layer, and thereafter, flows to the exhaust duct. The direction of flow of the drying gas in the vent path is changed over by gas supply-exhaust changeover dampers.

Abstract: An apparatus for applying a coating to a powdery or granular material has a rotary drum 20 including a tubular portion 21 formed with air holes 27 and hollow shaft portions 23 and 24 provided at opposite end portions in the axial direction. A coating chamber 26 is defined inside the rotary drum 20. Liquid is sprayed from a nozzle 32 onto an accumulated layer 33 of a powdery or granular material in the coating chamber 26. Drying gas supplied from an air supply duct 45 is introduced into the rotary drum 20 from one of the two hollow shaft portions 23 and 24. A plurality of axially extending air ducts 34 are provided on the outer periphery of the rotary drum 20. When an air duct is positioned downwardly it is communicated with an air exhaust duct 41 through a distributor 35. Air introduced from the air supply duct 45 is biased toward the accumulated layer 33 by louvers 48.

Abstract: A method of and an apparatus for sugar coating, the apparatus comprising: a rotatable vessel for containing a material to be coated; a baffle 9 movable independently of the rotatable vessel; a baffle mounting shaft 10 having a bent construction, for mounting the baffle 9 thereon; and a hydraulic cylinder for rocking the baffle mounting shaft 10 to displace the baffle 9. Load cells 17a and 17b for detecting the position of the baffle 9 relative to an accumulated layer M of a material to be coated are provided on the baffle 9. The load cells 17a and 17b serves for holding the position of the baffle 9 relative to the accumulated layer M of the material to be coated at all times, on the basis of a load imposed due to the presence of the contact with the material to be coated.

Abstract: A prolonged release dosage form of drug made by coating a surface of an ungranulated medicinal particle with a water-insoluble material which is physiologically acceptable and does not dissolve in water and gastric juice; and then, granulating or tableting the coated medicinal particles.

Abstract: A coating apparatus using jet air streams, wherein a spray nozzle (2) of the coating apparatus includes: a powder blow-out path (4) provided in an axially central portion of the main body (3) of the nozzle; a coating liquid blow-out path (5) annularly formed on the outer periphery of the powder blow-out path (4); and a compressed air blow-out path (6) having a taper-shaped outlet portion and annularly formed on the outer periphery of the coating liquid blow-out path (5).

Abstract: A pan coating apparatus wherein a blow-out portion is provided at the forward end of an air supply pipe inserted into a rotatable container, and the total opening area of gas outlets provided in the blow-out portion is set at 0.1-1 time that of perforations provided in a perforated plate of the rotatable container.