Abstract: A sample collection device including a housing extending from a mouthpiece portion to an air outlet portion. The housing defines an airflow channel from the mouthpiece portion to the air outlet portion. The mouthpiece portion is configured to receive an h exhalation airflow. A porous sample collection media is disposed within the housing and along the airflow channel. A fluid inlet port defines an aperture through the housing and is adjacent to the porous sample collection media. The fluid inlet port is configured to direct id onto the porous sample collection media. A metered fluid dose element is attached to the fluid inlet port. The metered fluid dose element is configured to dispense a metered volume of fluid into the fluid inlet port.

Abstract: The composition includes an antimicrobial monomer represented by formula CH2?C(R1)—C(O)—O-Q-N+(R)2CnH2n+1(X—), a non-fluorinated crosslinking monomer having at least two acrylate groups, methacrylate groups, or a combination thereof, a polar monomer having at least one of acrylic acid, methacrylic acid, or a carboxylate salt thereof, and a nonpolar monomer represented by formula CH2?C(R1)—C(O)—O—R2. The antimicrobial monomer, the non-fluorinated crosslinking monomer, the polar monomer, and the nonpolar monomer together account for greater than 95 percent by weight, based on the total weight of the composition. The article includes a film having a plurality of pendent groups represented by formula —C(O)—O-Q-N+(R)2CnH2n+1(X—) covalently bonded in a crosslinked non-fluorinated acrylic network. A method of making an article is also described.

Abstract: A transfer article includes an acrylate layer releasable from a release layer including a metal layer, a metal oxide layer, or a doped semiconductor layer at a release value of from 2 to 50 grams/inch (0.8 to 20 g/cm). A functional layer overlies the acrylate layer, wherein the functional layer includes at least one layer of a functional material selected to provide at least one of a therapeutic, aesthetic or cosmetic benefit on a dental appliance in a mouth of a patient, and wherein the transfer article has a thickness of less than 3 micrometers. A pattern of a transfer material is on a major surface of the functional layer, wherein the transfer material includes an adhesion modifying material chosen from release materials and adhesives.

Abstract: An article having anti-microbial effect is provided. The article includes an occlusive layer and a substrate having a nanostructured surface. The nanostructured surface is coated with a metal oxide layer and the metal oxide layer includes a metal oxide.

Abstract: A dental appliance includes a polymeric shell with an arrangement of one or more cavities configured to receive one or more teeth, and the polymeric shell includes an antimicrobial lipid, such as monolaurin, and optionally an enhancer.

Abstract: A dental appliance includes a polymeric shell with a first major surface having a plurality of cavities for receiving one or more teeth, and a layer of a metal oxide MOx on the first major surface.

Abstract: An article having anti-microbial effect is provided. The article includes an occlusive layer; a substrate having two opposing major surfaces, wherein one opposing major surface is a nanostructured surface; a metal oxide layer, wherein the nanostructured surface is coated with the metal oxide layer and the metal oxide layer comprises a metal oxide; and a metal layer overlaying the metal oxide layer.

Abstract: An article having anti-microbial effect is provided. The article includes an occlusive layer; a substrate overlaying the occlusive layer, wherein the substrate having two opposing major surfaces; a metal oxide layer overlaying the substrate, wherein the metal oxide layer comprises a metal oxide and wherein the metal oxide layer comprises less than 40 wt. % non-oxidized metal; and a metal layer overlaying the metal oxide layer.

Abstract: An article having anti-microbial effect is provided. The article includes an occlusive layer; a substrate overlaying the occlusive layer, wherein the substrate having two opposing major surfaces; a metal oxide layer overlaying one opposing major surface of the substrate, wherein the metal oxide layer comprises a metal oxide; and a metal layer overlaying the other opposing major surface of the substrate; wherein the substrate is between the metal oxide layer and the metal layer; and wherein electric potential of the metal oxide layer is at least 0.454V more than electric potential of the metal layer.

Abstract: An article having anti-microbial effect is provided. The article includes an occlusive layer; a substrate overlaying the occlusive layer, wherein the substrate having two opposing major surfaces; a metal oxide layer overlaying the substrate, wherein the metal oxide layer comprises a metal oxide and wherein the metal oxide layer comprises less than 40 wt. % non-oxidized metal; and a metal layer overlaying the metal oxide layer.

Abstract: An article having anti-microbial effect is provided. The article includes an occlusive layer and a substrate having a nanostructured surface. The nanostructured surface is coated with a metal oxide layer and the metal oxide layer includes a metal oxide.

Abstract: An article having anti-microbial effect is provided. The article includes an occlusive layer, an absorbent layer over-laying the occlusive layer, and a metal oxide layer overlaying the absorbent layer, wherein the metal oxide layer comprises a metal oxide and wherein the metal oxide layer comprises less than 40 wt. % non-oxidized metal.

Abstract: An antimicrobial pressure-sensitive adhesive (PSA). The PSA system can include an antimicrobial polymer having a plurality of pendant groups. The plurality of pendant groups can include (i) a first pendant group comprising a nonpolar compound, (ii) a second pendant group comprising a quaternary ammonium compound, and (iii) a third pendant group different from the first pendant group or the second pendent group, wherein the third pendant group provides inter-reactivity, such that the antimicrobial polymer can include one or more intermolecular interactions. The antimicrobial polymer can be free of non-ionic hydrophilic moieties. The PSA system can have a glass transition temperature Tg ranging from 0 to 50 degrees C.

Abstract: Light-activated antimicrobial devices and articles are disclosed. The devices include a light source and a light-activated antimicrobial article comprising a photosensitizer and a viscoelastic material such as a pressure sensitive adhesive adapted to receive light from the light source. The viscoelastic material may be adapted to transport light by total internal reflection. The photosensitizer may comprise a dye, a metal oxide or a composition that comprises anions that oxidize or react to form a gas. Upon activation of the light source, the photosensitizer absorbs light from the light source such that antimicrobial activity is exhibited. The photosensitizer may be included in the light-activated antimicrobial article or it may be provided as a topical composition that is separate from the article. The light-activated antimicrobial articles and devices may have constructions similar to those of wound dressings.

Abstract: Antimicrobial compositions including an antimicrobial lipid, such as a fatty acid ester, fatty ether, or alkoxide derivative thereof, an enhancer, a surfactant, water, and an optional hydrophilic co-solvent. Such compositions provide effective topical antimicrobial activity and are accordingly useful in cleaning surfaces.

Abstract: A method of making a coatable composition includes: a) providing a initial composition comprising silica nanoparticles dispersed in an aqueous liquid medium, wherein the silica nanoparticles have a particle size distribution with an average particle size of less than or equal to 100 nanometers, and wherein the silica sol has a pH greater than 6; b) acidifying the initial composition to a pH of less than or equal to 4 using inorganic acid to provide an acidified composition; and c) dissolving at least one metal compound in the acidified composition to provide a coatable composition. The at least one metal compound includes at least one of a silver compound, a zinc compound, and a copper compound. Coatable compositions, antimicrobial compositions, preparable by the method are also disclosed. Antimicrobial articles including the antimicrobial compositions are also disclosed.

Abstract: The disclosure provides polymers having antimicrobial activity and articles with the polymers coated thereon. The polymers include a first pendant group comprising a first quaternary ammonium component, a second pendant group comprising a nonpolar component, and a third pendant group comprising an organosilane component. The disclosure also includes methods of coating articles with the antimicrobial polymers. The methods further include the use of adhesion-promoting reagents.

Abstract: A light-activated antimicrobial article is disclosed, consisting essentially of an acridine dye covalently bonded without a linking group to a nylon material. The article may be made using electron beam processing. The article in combination with light absorbed by the acridine dye may be used to inhibit the growth of microorganisms. A photosensitive nylon material in which the acridine dye is disposed on the nylon material may also be used. Medical kits that include a light source and an article having the acridine dye are disclosed.

Abstract: Methods of making a (e.g. dilute) cleaning solution from a hydrogel cleaning concentrate, packages of hydrogel cleaning concentrate, and methods of making a hydrogel cleaning concentrate are described.

Abstract: The present disclosure describes methods for making shaped polymeric materials. Methods are provided for making shaped polymeric materials from a precursor composition that contains a polar solvent and a polymerizable material that is miscible with the polar solvent. The precursor composition is at least partially polymerized in a mold.