Patents by Inventor Naruhito Higo
Naruhito Higo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230201139Abstract: Described are methods for reducing the formation of amphetamine carbamate and amphetacarbamate in transdermal amphetamine compositions, compositions with low levels of amphetacarbamate, and methods using such compositions for transdermal delivery of amphetamine.Type: ApplicationFiled: January 3, 2023Publication date: June 29, 2023Applicant: Noven Pharmaceuticals, Inc.Inventors: Atsushi Sonobe, Deboprosad Mondal, Naruhito Higo
-
Patent number: 11559501Abstract: Described are methods for reducing the formation of amphetamine carbamate and amphetacarbamate in transdermal amphetamine compositions, compositions with low levels of amphetacarbamate, and methods using such compositions for transdermal delivery of amphetamine.Type: GrantFiled: January 6, 2022Date of Patent: January 24, 2023Assignee: NOVEN PHARMACEUTICALS, INC.Inventors: Atsushi Sonobe, Deboprosad Mondal, Naruhito Higo
-
Publication number: 20220218628Abstract: Described are methods for reducing the formation of amphetamine carbamate and amphetacarbamate in transdermal amphetamine compositions, compositions with low levels of amphetacarbamate, and methods using such compositions for transdermal delivery of amphetamine.Type: ApplicationFiled: January 6, 2022Publication date: July 14, 2022Applicant: NOVEN PHARMACEUTICALS, INC.Inventors: Atsushi Sonobe, Deboprosad Mondal, Naruhito Higo
-
Patent number: 9308187Abstract: A patch comprising a support layer and an adhesive layer, wherein the adhesive layer comprises diclofenac sodium, dimethyl sulfoxide, and citric acid; a mass ratio between the diclofenac sodium and the citric acid (mass of diclofenac sodium:mass of citric acid) is 1:0.15 to 1:0.45; and a mass ratio between the diclofenac sodium and the dimethyl sulfoxide (mass of diclofenac sodium:mass of dimethyl sulfoxide) is 1:0.75 to 1:3.Type: GrantFiled: June 17, 2013Date of Patent: April 12, 2016Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Eisuke Hatanaka, Yasunori Takada, Takaaki Terahara, Naruhito Higo
-
Publication number: 20150202171Abstract: A patch comprising a support layer and an adhesive layer, wherein the adhesive layer comprises diclofenac sodium, dimethyl sulfoxide, and citric acid; a mass ratio between the diclofenac sodium and the citric acid (mass of diclofenac sodium:mass of citric acid) is 1:0.15 to 1:0.45; and a mass ratio between the diclofenac sodium and the dimethyl sulfoxide (mass of diclofenac sodium:mass of dimethyl sulfoxide) is 1:0.75 to 1:3.Type: ApplicationFiled: June 17, 2013Publication date: July 23, 2015Applicant: HISAMITSU PHARACEUTICAL CO., INC.Inventors: Eisuke Hatanaka, Yasunori Takada, Takaaki Terahara, Naruhito Higo
-
Patent number: 8802134Abstract: A method for producing a patch having a high skin penetrability and a high pharmaceutical physical properties such as adhesion and cohesiveness, and a long-term storability. The patch is produced by first obtaining an adhesive agent layer composition containing oxybutynin and/or salt thereof as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, an organic acid, and a tackifier; heating the adhesive agent layer composition at a temperature in a range from a melting point of the drug to a temperature higher than the melting point by 10° C. for 2 to 24 hours; and slowly cooling the heated adhesive agent layer composition to obtain the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.Type: GrantFiled: February 21, 2013Date of Patent: August 12, 2014Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Naruhito Higo, Tetsurou Tateishi, Takaaki Terahara, Kazunosuke Aida, Shigeki Hayashi, Nobuo Tsutsumi
-
Publication number: 20140161865Abstract: A method for producing a patch having a high skin penetrability and a high pharmaceutical physical properties such as adhesion and cohesiveness, and a long-term storability. The patch is produced by first obtaining an adhesive agent layer composition containing oxybutynin and/or salt thereof as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, an organic acid, and a tackifier; heating the adhesive agent layer composition at a temperature in a range from a melting point of the drug to a temperature higher than the melting point by 10° C. for 2 to 24 hours; and slowly cooling the heated adhesive agent layer composition to obtain the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.Type: ApplicationFiled: February 21, 2013Publication date: June 12, 2014Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Naruhito Higo, Tetsurou Tateishi, Takaaki Terahara, Kazunosuke Aida, Shigeki Hayashi, Nobuo Tsutsumi
-
Patent number: 8691267Abstract: A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with a drug and an adhesive base agent, wherein the adhesive base agent comprises styrene-isoprene-styrene block copolymer, 2-ethylhexyl acrylate-vinyl acetate copolymer and a basic nitrogen-including polymer including a basic nitrogen and having no adhesion property at normal temperature.Type: GrantFiled: August 7, 2003Date of Patent: April 8, 2014Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Takaaki Terahara, Kazunosuke Aida, Arata Toshimitsu, Naruhito Higo
-
Patent number: 8420117Abstract: A patch formulation for external use where a basic drug, an organic acid and an organic acid salt are combined as essential components is disclosed. The basic drug is preferably in the form of its acid addition salt. The organic acid is preferably a carboxylic acid having carbon atoms of 2 to 7, and more preferably at least one acid selected from the group consisting of acetic, lactic, tartaric, citric, malic, benzoic and salicylic acids. The organic acid salt is preferably a metal salt of a carboxylic acid, and more preferably sodium acetate.Type: GrantFiled: July 6, 2010Date of Patent: April 16, 2013Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Hideharu Chono, Toshiro Yamaguchi, Hisakazu Kurita, Tetsuro Tateishi, Naruhito Higo
-
Patent number: 8275454Abstract: An iontophoresis device activated in use, which is capable of supplying a dissolution liquid in an amount that depends on the amount of a drug when it is used, is provided. This iontophoresis device activated in use comprises: an absorber 11 formed of a material containing a dry drug 10 and capable of absorbing a liquid; a wall material 13 disposed around the absorber 11, having an adhesive layer 12 on the undersurface thereof; a support 15 disposed on the absorber 11 and the wall material 13, having an opening 14 in the central portion thereof; an electrode 25 disposed on the undersurface of the support 15; a diaphragm 20 disposed on the support 15; and a dissolution liquid reservoir 18 disposed on the diaphragm 20, retaining a dissolution liquid for dissolving the drug between the diaphragm 20 and itself, and having a protruding portion 17 for destroying the diaphragm 20 by pressing force.Type: GrantFiled: December 27, 2004Date of Patent: September 25, 2012Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Hirotoshi Adachi, Seiji Tokumoto, Naruhito Higo
-
Patent number: 8173155Abstract: The present invention relates an adhesive patch comprising a backing layer and an adhesive layer that contains a drug, wherein the adhesive layer contains a mixed adhesive base containing a hydrocarbon rubber and a silicon-containing polymer. The adhesive patch of the invention shows extremely superior skin absorbability of a drug in a preparation, reduced skin irritation, and excellent aging stability of the drug in the preparation, and can achieve easiness of drug-taking methods and improvement in compliance.Type: GrantFiled: May 31, 2005Date of Patent: May 8, 2012Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Takashi Yasukochi, Tetsuro Tateishi, Naruhito Higo
-
Publication number: 20120095386Abstract: Device structure 100 for iontophoresis provides electrode 101 and electrically conductive layer 102. Electrically conductive layer 102 contains active ingredient D and basic water swelling methacrylate copolymer P1 and/or acidic water swelling methacrylate copolymer P2. Electrode 101 and electrically conductive layer 102 are placed into a hollow of backing 103 and electrode terminal 104 is connected to electrode 101 through backing 103. Adhesive layer 105 is set around backing 103, and liner 106 to be removed when using the device, is placed so as to cover the hollow of backing 103.Type: ApplicationFiled: October 1, 2010Publication date: April 19, 2012Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Hirotoshi Adachi, Noriyuki Kuzumaki, Tetsuya Arimoto, Naruhito Higo
-
Patent number: 8155738Abstract: Device structure 100 for iontophoresis provides electrode 101 and electrically conductive layer 102. Electrically conductive layer 102 contains active ingredient D and basic water swelling methacrylate copolymer P1 and/or acidic water swelling methacrylate copolymer P2. Electrode 101 and electrically conductive layer 102 are placed into a hollow of backing 103 and electrode terminal 104 is connected to electrode 101 through backing 103. Adhesive layer 105 is set around backing 103, and liner 106 to be removed when using the device, is placed so as to cover the hollow of backing 103.Type: GrantFiled: October 1, 2010Date of Patent: April 10, 2012Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Hirotoshi Adachi, Noriyuki Kuzumaki, Tetsuya Arimoto, Naruhito Higo
-
Patent number: 7988991Abstract: A patch agent of the present invention comprises a support, and an adhesive layer laid on the support and containing an adhesive base and a drug, wherein the adhesive base contains an acrylic polymer substantially having no carboxyl and no hydroxyl in molecules thereof, and a rubber-based polymer, so as to achieve sufficiently high skin permeability of the drug and preparation properties. Accordingly, the present invention enables administration of the drug through skin to be implemented with drug administration effect at a sufficiently high level and on a stable basis.Type: GrantFiled: March 7, 2002Date of Patent: August 2, 2011Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Tetsuro Tateishi, Takaaki Terahara, Naruhito Higo
-
Publication number: 20110152743Abstract: An iontophoresis device activated in use, which is capable of supplying a dissolution liquid in an amount that depends on the amount of a drug when it is used, is provided. This iontophoresis device activated in use comprises: an absorber 11 formed of a material containing a dry drug 10 and capable of absorbing a liquid; a wall material 13 disposed around the absorber 11, having an adhesive layer 12 on the undersurface thereof; a support 15 disposed on the absorber 11 and the wall material 13, having an opening 14 in the central portion thereof; an electrode 25 disposed on the undersurface of the support 15; a diaphragm 20 disposed on the support 15; and a dissolution liquid reservoir 18 disposed on the diaphragm 20, retaining a dissolution liquid for dissolving the drug between the diaphragm 20 and itself, and having a protruding portion 17 for destroying the diaphragm 20 by pressing force.Type: ApplicationFiled: December 27, 2004Publication date: June 23, 2011Inventors: Hirotoshi Adachi, Seiji Tokumoto, Naruhito Higo
-
Patent number: 7914813Abstract: It is intended to provide an interface for a transdermal drug administration device that can supply a drug almost evenly and favorably from a plurality of projections through skin. This interface for a transdermal drug administration device has a flat plate 8. The flat plate 8 comprises a plurality of two-dimensionally arranged conical or pyramidal projections 6 capable of piercing skin and a plurality of openings 7 capable of delivering a drug which are respectively arranged in correspondence with the projections. The openings 7 are respectively arranged in proximity to their corresponding projections 6. The flat plate 8 can be made of a metal or ceramics. The ratio between the number of the openings and the number of the projections can be 1:1 to 1:2.Type: GrantFiled: February 2, 2005Date of Patent: March 29, 2011Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Hirotoshi Adachi, Seiji Tokumoto, Naruhito Higo
-
Patent number: 7883719Abstract: A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with an adhesive agent and oxybutynin and/or a pharmaceutically acceptable salt thereof, wherein the adhesive agent comprises an acrylic polymer substantially free of both carboxyl group and hydroxyl group and a rubber polymer, in which weight ratio of content of the acrylic polymer to content of the rubber polymer is from 1:4 to 1:19.Type: GrantFiled: August 7, 2003Date of Patent: February 8, 2011Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Takeshi Ito, Tetsuro Tateishi, Naruhito Higo
-
Publication number: 20110027365Abstract: A patch formulation for external use where a basic drug, an organic acid and an organic acid salt are combined as essential components is disclosed. The basic drug is preferably in the form of its acid addition salt. The organic acid is preferably a carboxylic acid having carbon atoms of 2 to 7, and more preferably at least one acid selected from the group consisting of acetic, lactic, tartaric, citric, malic, benzoic and salicylic acids. The organic acid salt is preferably a metal salt of a carboxylic acid, and more preferably sodium acetate.Type: ApplicationFiled: July 6, 2010Publication date: February 3, 2011Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Hideharu Chono, Toshiro Yamaguchi, Hisakazu Kurita, Tetsuro Tateishi, Naruhito Higo
-
Publication number: 20110021972Abstract: Device structure 100 for iontophoresis provides electrode 101 and electrically conductive layer 102. Electrically conductive layer 102 contains active ingredient D and basic water swelling methacrylate copolymer P1 and/or acidic water swelling methacrylate copolymer P2. Electrode 101 and electrically conductive layer 102 are placed into a hollow of backing 103 and electrode terminal 104 is connected to electrode 101 through backing 103. Adhesive layer 105 is set around backing 103, and liner 106 to be removed when using the device, is placed so as to cover the hollow of backing 103.Type: ApplicationFiled: October 1, 2010Publication date: January 27, 2011Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Hirotoshi Adachi, Noriyuki Kuzumaki, Tetsuya Arimoto, Naruhito Higo
-
Patent number: RE45936Abstract: An adhesive which comprises aqueous and nonaqueous polymers suitable for holding an lipophilic drug, etc., and has tackiness and cohesiveness which are sufficient for the plaster of a patch; and a patch employing the adhesive. The adhesive contains a polymer which comprises one or more kinds of acrylic or methacrylic monomer units, at least one kind of the monomer units having a hydroxy group, and which has been crosslinked with a boron compound.Type: GrantFiled: April 24, 2008Date of Patent: March 22, 2016Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Takashi Yasukochi, Toshiro Yamaguchi, Tetsuro Tateishi, Naruhito Higo