Patents by Inventor Nasim Annabi

Nasim Annabi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190070338
    Abstract: Neurosupportive materials that possess strong tissue adhesion were synthesized by photocrosslinking two polymers, gelatin methacryloyl (GelMA) and methacryloyl-substituted tropoelastin (MeTro). The engineered materials exhibited tunable mechanical properties by varying the GelMA/MeTro ratio. In addition, GelMA/MeTro hydrogels exhibited 15-fold higher adhesive strength to nerve tissue ex vivo compared to traditionally used fibrin-based materials. Furthermore, the composites were shown to support Schwann cell (SC) viability and proliferation, as well as neurite extension and glial cell participation in vitro, which are essential cellular components for nerve regeneration. Finally, subcutaneously implanted GelMA/MeTro hydrogels exhibited slower degradation in vivo compared with pure GelMA, indicating its potential to support the growth of slowly regenerating nerves.
    Type: Application
    Filed: August 22, 2018
    Publication date: March 7, 2019
    Inventors: Jonathan R. Soucy, Ehsan Shirzaei Sani, Abigail N. Koppes, Ryan A. Koppes, Nasim Annabi
  • Publication number: 20190022280
    Abstract: The present invention provides compositions and methods for repair and reconstruction of defects and injuries to the cornea.
    Type: Application
    Filed: February 8, 2017
    Publication date: January 24, 2019
    Applicants: The Brigham and Women's Hospital, Inc., Massachusetts Eye and Ear Infirmary
    Inventors: Ali KHADEMHOSSEINI, Nasim ANNABI, Reza DANA, Ahmad KHEIRKHAH
  • Publication number: 20180362693
    Abstract: A biodegradable and biocompatible hydrogel of tunable conductivity is provided. The hydrogel includes a polymer conjugated to a bio-ionic liquid. The mechanical and electrical properties of the hydrogel can be varied by altering the ratio of the polymer to the bio-ionic liquid in the conjugated polymer. These properties can be varied also by changing the percent weight of the conjugated polymer in the hydrogel. A method for preparing the hydrogel is also provided.
    Type: Application
    Filed: December 29, 2016
    Publication date: December 20, 2018
    Inventors: Nasim ANNABI, Iman NOSHADI
  • Publication number: 20180111978
    Abstract: Disclosed herein are polypeptides comprising an amino acid sequence of {[VPGVG]4IPGVG}n, wherein n is an integer greater than 1. The polypeptides can be crosslinked to from biocompatible hydrogels with tunable and desirable mechanical properties. The polypeptides and hydrogels can be used in a variety of biomedical applications including treatment of bleeding, treatment of soft tissue injury, injectable filler, and tissue adhesives.
    Type: Application
    Filed: March 18, 2016
    Publication date: April 26, 2018
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Nasim ANNABI, Ali KHADEMHOSSEINI
  • Publication number: 20170232138
    Abstract: The present invention provides an improved tissue adhesive to repair defects in soft tissue. Following ASTM standard tests, crosslinked methacryloyl-substituted gelatin hydrogels of the present invention (GelSEAL) were shown to exhibit adhesive properties, i.e. wound closure strength, shear resistance and burst pressure, that were superior to clinically used fibrin- and poly(ethylene glycol)-based glues. Chronic in vivo experiments in rats proved GelSEAL to effectively seal large lung leakages without additional sutures or staples, presenting improved performance as compared to fibrin and poly(ethylene glycol) glues. Furthermore, subcutaneous implantation in rats revealed high biocompatibility of GelSEAL as evidenced by low inflammatory host response.
    Type: Application
    Filed: August 6, 2015
    Publication date: August 17, 2017
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Ali KHADEMHOSSEINI, Nasim ANNABI, Alexander ASSMANN
  • Patent number: 9688741
    Abstract: The present invention relates to hydrogels and to the use of hydrogels for repair or restoration of tissue. In particular, the hydrogels of the present invention can be used for the repair or restoration of cardiac tissue.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: June 27, 2017
    Assignees: Elastagen Pty Ltd, President and Fellows of Harvard College
    Inventors: Nasim Annabi, Anthony Steven Weiss, Ali Khademhosseini
  • Publication number: 20150274805
    Abstract: The present invention relates to hydrogels and to the use of hydrogels for repair or restoration of tissue. In particular, the hydrogels of the present invention can be used for the repair or restoration of cardiac tissue.
    Type: Application
    Filed: October 23, 2013
    Publication date: October 1, 2015
    Applicant: Elastagen Pty Ltd.
    Inventors: Nasim Annabi, Anthony Steven Weiss, Ali Khademhosseini