Abstract: Disclosed is a method and composition for using plant extracellular vesicles (EVs) as vectors for delivering therapeutic molecules to the CNS. We demonstrated that plant EVs are more efficient vectors than delivery with other methods. These vectors can used to treat diseases in the CNS, such as cancer, injuries like TBI, degeneration such as Alzheimer's and aging and cognitive disorders such as PTSD, depression and anxiety. New data using hemp derived EVs to treat cancers in the brain and to impact precursor cells in the brain and isolation of EVs are included. In addition, disclosed is an improvement on the efficacy of intra-nasal delivery and oral delivery when using EVs.

Abstract: An injector device for percutaneously injecting biomaterial in the form of particles of different sizes or in the form of paste includes a trocar (12) of generally cylindrical shape presenting a open first end with a sharp edge, the wall of the first end presenting at least one orifice (36, 38) for passing the biomaterial, and a second end (42) that is likewise open; a reservoir (14) for receiving the biomaterial, the reservoir including a part (20) of substantially cylindrical shape having two open ends, the cylindrical part being capable of being inserted at least in a portion of the trocar via the second end thereof; removable plugs for closing both ends of the reservoir; and a piston (16) insertable in the cylindrical part when the plugs are removed, the piston being capable of sliding in the cylindrical part and in the first end of the trocar.

Abstract: A system and method of an instrument conversion machine, where the instrument may include life insurance policies, particularly senior life settlements and their derivatives to provide liquidity and an investment vehicle to holders of life insurance policies. The machine divides a plurality of the instruments into a plurality of instrument pools that each includes at least one of the plurality of instruments, where the dividing is based on pre-set criteria. For each of the pools, the machine subdivides the pool into a plurality of instrument securities, each of the plurality of instrument securities representing a right to a respective one of the plurality of pools. The machine outputs, receives, and stores data for transfer of the securities between parties.

Abstract: The invention relates to an injector device for percutaneously injecting biomaterial in the form of particles of different sizes or in the form of paste. The device comprises: a trocar (12) of generally cylindrical shape presenting an open first end with a sharp edge, the wall of said first end presenting at least one orifice (36, 38) for passing the biomaterial, and a second end (42) that is likewise open; a reservoir (14) for receiving said biomaterial, the reservoir comprising a part (20) of substantially cylindrical shape having two open ends, said cylindrical part being capable of being inserted at least in a portion of the trocar via the second end thereof, and removable means for closing both ends of the reservoir; and a piston (16) insertable in said cylindrical part when said closure means are removed, said piston being capable of sliding in said cylindrical part and in the first end of the trocar.