Patents by Inventor Nassim Usman

Nassim Usman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis deprotection analysis and purification of RNA and ribozymes
    Patent number: 5831071
    Abstract: A process for deprotecting RNA 2'-O-alkylsilyl groups comprising, contacting the groups with a solution of anhydrous triethylamine-hydrogen fluoride (aHF-TEA) in triethylamine and N-methylpyrrolidine at between 60.degree. C.-70.degree. C. for 0.25-24 h.
    Type: Grant
    Filed: August 29, 1997
    Date of Patent: November 3, 1998
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott
  • Deprotection of RNA with alkylamine
    Patent number: 5804683
    Abstract: A method for the deprotection of RNA comprising reacting an alkylamine or ammonium hydroxide/alkylamine mixture with the RNA at 60-70 degrees Centigrade for 5 to 15 minutes in order to remove any exocyclic protecting groups, wherein said alkylamine is selected from the group consisting of ethylamine, propylamine, and butylamine.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: September 8, 1998
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine E. Wincott, Danuta Tracz
  • Base-modified enzymatic nucleic acid
    Patent number: 5767263
    Abstract: Method to produce a more active ribozyme by introducing a modified base into a substrate binding arm of the ribozyme or its catalytic core.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: June 16, 1998
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Leonid Beigelman, James McSwiggen, Alex Karpeisky
  • Chemical linkage of ribozyme protions
    Patent number: 5728818
    Abstract: Method for synthesis of an enzymatic nucleic acid by providing a 3' and a 5' portion of the enzymatic nucleic acid having independent chemically reactive groups at the 5' and 3' positions, respectively, under conditions in which a covalent bond is formed between the 3' and 5' portions by the chemically reactive groups. The bond is selected from the group consisting of, disulfide, morpholino, amide, ether, thioether, amine, a double bond, sulfonamide, ester, carbonate, and hydrazone. The bond is not the natural bond formed between a 5' phosphate group and a 3' hydroxyl group.
    Type: Grant
    Filed: January 16, 1996
    Date of Patent: March 17, 1998
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Francine Wincott, Nassim Usman
  • Base-modified enzymatic nucleic acid
    Patent number: 5672501
    Abstract: An enzymatic nucleic acid having a modification selected from pyridin-4-one, pyridin-2-one, phenyl, pseudouracil, 2, 4, 6-trimethoxy benzene, 3-methyluracil, dihydrouracil, naphthyl, 6-methyl-uracil and aminophenyl.
    Type: Grant
    Filed: October 5, 1995
    Date of Patent: September 30, 1997
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Jasenka Matulic-Adamic, Leonid Beigelman, Nassim Usman, Alex Karpeisky, Alex Burgin
  • Nucleozymes
    Patent number: 5652094
    Abstract: Nucleozymes containing ribonucleotides and deoxyribonucleotides or nucleic acid analogues are described herein. The nucleozymes have catalytic activity and are significantly more resistant to degradation than their all-RNA ribozyme counterparts. Also described are methods for preparing the nucleozymes along with methods of using nucleozymes, e.g., as therapeutic agents.
    Type: Grant
    Filed: January 31, 1992
    Date of Patent: July 29, 1997
    Assignees: University of Montreal, Massachusetts Institute of Technology
    Inventors: Nassim Usman, Robert J. Cedergren, Jean-Pierre Perreault, Jing-Hua Yang, Alexander Rich
  • 2'-deoxy-2'alkylnucleotide containing nucleic acid
    Patent number: 5639647
    Abstract: 2'-deoxy-2'-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules are disclosed.
    Type: Grant
    Filed: March 29, 1994
    Date of Patent: June 17, 1997
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Alexander Karpeisky, Leonid Beigelman, Anil Modak
  • N-phthaloyl-protected 2'-amino-nucleoside phosphoramdites
    Patent number: 5631360
    Abstract: A method for blocking the 2'-amino group of a nucleoside phosphoramidite using an N-phthaloyl protecting group. The 2'-amino-N-phthaloyl protected nucleotides are also disclosed.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: May 20, 1997
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, David Sweedler, Leonid Beigelman
  • 2'deoxy-2'-alkylnucleotide containing nucleic acid
    Patent number: 5627053
    Abstract: 2'-deoxy-2'-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: May 6, 1997
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Alexander Karpeisky, Leonid Beigelman, Anil Modak