Patents by Inventor Nassir F. Marrouche
Nassir F. Marrouche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11602270Abstract: The present disclosure relates to systems and methods for generating three-dimensional tissue maps, and particularly fibrosis maps of cardiac tissue. An intravascular device includes an elongated member and a distal tip. An imaging assembly is integrated with the elongated member to enable imaging of the microstructure of tissue near the distal tip. One or more navigation electrodes are positioned at or near the distal tip. Electrical mapping and/or ablation assemblies may also be integrated with the device. Images may be characterized according to a level of fibrosis and, using the corresponding determined locations of the images, a three-dimensional map showing areas of differential fibrosis may be generated. Electrical mapping data may also be integrated with the fibrosis map to generate a composite fibrosis and voltage map.Type: GrantFiled: January 31, 2018Date of Patent: March 14, 2023Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: Frank B. Sachse, Robert W. Hitchcock, Nassir F. Marrouche, Nathan J. Knighton, Chao Huang
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Patent number: 11154186Abstract: A catheter for imaging and treating a selected tissue and method of use is provided. Imaging, and treatment assemblies may be co-located at a distal end of a single catheter. The imaging assembly may include at least a portion of a confocal microscope. The treatment assembly may include at least a portion of the imaging assembly. A method of treating a selected tissue is also provided. The method may be performed using a single catheter. The imaging and treatment steps of the method may be performed simultaneously.Type: GrantFiled: July 28, 2016Date of Patent: October 26, 2021Assignee: University of Utah Research FoundationInventors: Frank B. Sachse, Robert W. Hitchcock, Nassir F. Marrouche, Nathan J. Knighton, Chao Huang
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Patent number: 10726545Abstract: Methods and systems are described for treatment of atrial fibrillation. Certain embodiments provide methods of assessing a risk of thromboembolic stroke in a patient. The method comprises acquiring image data and determining an indicator of a degree of fibrosis of a patient's left atrium (LA) based on the image data. A treatment modality is then determined and administered to the patient based on the analysis of the image data.Type: GrantFiled: January 22, 2018Date of Patent: July 28, 2020Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: Nassir F. Marrouche, Rob MacLeod, Evgueni Kholmovski, Christopher McGann, Joshua Blauer, Troy Badger, Robert Sillman Oakes, Nathan Burgon, Marcos Daccarett
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Publication number: 20200093408Abstract: Systems, methods, and sensor devices for identifying one or more changes in a stimulus-responsive hydrogel include a sensor device having (i) a sensing structure and (ii) a stimulus-responsive hydrogel associated with a first side of the sensing structure. The sensing structure includes a flexible thin film polymer and an electric sensing element capable of electric impedance change, and the hydrogel is configured to dimensionally change in response to predefined stimuli such that a dimensional change of the hydrogel causes a change in an impedance property of the electric sensing element. Systems including such a sensor device can additionally include a meter in electrical communication with the sensor device to identify changes in the impedance properties of the structure and/or a catheter sheath configured for placement within an in vivo environment and is sized and shaped to receive the sensor device within a lumen thereof.Type: ApplicationFiled: June 12, 2018Publication date: March 26, 2020Inventors: Florian Solzbacker, Stan Kanarowski, Jules John Magda, Mahender Nath Avula, Tatjana S. Bevans, Nassir F. Marrouche, Derek J. Sakata, Julia Koerner, Christopher Reiche
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Publication number: 20200022573Abstract: The present disclosure relates to systems and methods for generating three-dimensional tissue maps, and particularly fibrosis maps of cardiac tissue. An intravascular device includes an elongated member and a distal tip. An imaging assembly is integrated with the elongated member to enable imaging of the microstructure of tissue near the distal tip. One or more navigation electrodes are positioned at or near the distal tip. Electrical mapping and/or ablation assemblies may also be integrated with the device. Images may be characterized according to a level of fibrosis and, using the corresponding determined locations of the images, a three-dimensional map showing areas of differential fibrosis may be generated. Electrical mapping data may also be integrated with the fibrosis map to generate a composite fibrosis and voltage map.Type: ApplicationFiled: January 31, 2018Publication date: January 23, 2020Inventors: Frank B. Sachse, Robert W. Hitchcock, Nassir F. Marrouche, Nathan J. Knighton, Chao Huang
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Patent number: 10506945Abstract: A device for performing an MRI scan using patient specific scan parameters and a method of optimizing MRI image quality with patient specific scan parameters. The device includes a processor configured to receive MRI scout scan data of a patient injected with a contrast agent, generate a series of MRI scout scan images of the patient, select an initial inversion time (TIinitial) based on the MRI scout scan images, determine a time interval between adjacent inversion pulses (TR) based on an ECG of the patient, calculate a relaxation time (T1) based on TIinitial and TR, calculate an optimized inversion time (TIoptimized) based on the T1, and generate an output to an MRI device to perform an MRI scan of the patient based on TIoptimized.Type: GrantFiled: June 25, 2018Date of Patent: December 17, 2019Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: Nassir F. Marrouche, Evgueni G. Kholmovski
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Patent number: 10194830Abstract: A method of monitoring a position of a catheter tip relative to a target tissue. The method includes steps of identifying a wall structure in the target tissue; guiding a catheter towards the wall structure; monitoring a location of the catheter; directing a navigator beam towards the wall structure; aligning the navigator beam with the location of the catheter; monitoring a position of the wall structure using the navigator beam; and determining the position of the wall structure relative to the location of the catheter.Type: GrantFiled: March 13, 2014Date of Patent: February 5, 2019Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: Ashvin Kurian George, Evgueni G. Kholmovski, Nassir F. Marrouche
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Publication number: 20180303374Abstract: A method of optimizing scan parameters for LGE-MRI. At least one cardiac MRI TI scout scan is performed by applying an inversion pulse every predetermined heartbeat of a patient. An initial value of an inversion time TIinitial is determined by assessing a set of images generated from the scout scan. A first multiple of a duration between successive indicia of ventricular depolarization is selected, and a relaxation time T1 is determined based on the initial value Tinitial and the first multiple of duration. An optimized inversion time TIoptimal for LGE-MRI is determined based on the relaxation time T1 and a second multiple of a duration between successive indicia of ventricular depolarization. A correction factor is determined based on the optimized inversion time TIoptimal from the initial value of the inversion time TIinitial.Type: ApplicationFiled: June 25, 2018Publication date: October 25, 2018Inventors: Nassir F. Marrouche, Evgueni G. Kholmovski
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Publication number: 20180240234Abstract: Methods and systems are described for treatment of atrial fibrillation. Certain embodiments provide methods of assessing a risk of thromboembolic stroke in a patient. The method comprises acquiring image data and determining an indicator of a degree of fibrosis of a patient's left atrium (LA) based on the image data. A treatment modality is then determined and administered to the patient based on the analysis of the image data.Type: ApplicationFiled: January 22, 2018Publication date: August 23, 2018Inventors: Nassir F. MARROUCHE, Rob MACLEOD, Evgueni KHOLMOVSKI, Christopher MCGANN, Joshua BLAUER, Troy BADGER, Robert Sillman OAKES, Nathan BURGON, Marcos DACCARETT
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Patent number: 10004425Abstract: A method of optimizing scan parameters for LGE-MRI. At least one cardiac MRI TI scout scan is performed by applying an inversion pulse every predetermined heartbeat of a patient. An initial value of an inversion time TIinitial is determined by assessing a set of images generated from the scout scan. A first multiple of a duration between successive indicia of ventricular depolarization is selected, and a relaxation time T1 is determined based on the initial value Tinitial and the first multiple of duration. An optimized inversion time TIoptimal for LGE-MRI is determined based on the relaxation time T1 and a second multiple of a duration between successive indicia of ventricular depolarization. A correction factor is determined based on the optimized inversion time TIoptimal from the initial value of the inversion time TIinitial.Type: GrantFiled: July 25, 2017Date of Patent: June 26, 2018Assignee: University of Utah Research FoundationInventors: Nassir F. Marrouche, Evgueni G. Kholmovski
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Publication number: 20170332940Abstract: A method of optimizing scan parameters for LGE-MRI. At least one cardiac MRI TI scout scan is performed by applying an inversion pulse every predetermined heartbeat of a patient. An initial value of an inversion time TIinitial is determined by assessing a set of images generated from the scout scan. A first multiple of a duration between successive indicia of ventricular depolarization is selected, and a relaxation time T1 is determined based on the initial value Tinitial and the first multiple of duration. An optimized inversion time TIoptimal for LGE-MRI is determined based on the relaxation time T1 and a second multiple of a duration between successive indicia of ventricular depolarization. A correction factor is determined based on the optimized inversion time TIoptimal from the initial value of the inversion time TIinitial.Type: ApplicationFiled: July 25, 2017Publication date: November 23, 2017Inventors: Nassir F. Marrouche, Evgueni G. Kholmovski
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Patent number: 9713436Abstract: A method of optimizing scan parameters for LGE-MRI. At least one cardiac MRI TI scout scan is performed by applying an inversion pulse every predetermined heart beat of a patient. An initial value of an inversion time TIinitial is determined by assessing a set of images generated from the scout scan. A first multiple of a duration between successive indicia of ventricular depolarization is selected, and a relaxation time T1 is determined based on the initial value Tinitial and the first multiple of duration. An optimized inversion time TIoptimal for LGE-MRI is determined based on the relaxation time T1 and a second multiple of a duration between successive indicia of ventricular depolarization. A correction factor is determined based on the optimized inversion time TIoptimal from the initial value of the inversion time TIinitial.Type: GrantFiled: October 30, 2012Date of Patent: July 25, 2017Assignee: University of Utah Research FoundationInventors: Nassir F. Marrouche, Evgueni G. Kholmovski
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Publication number: 20170027503Abstract: A catheter for imaging and treating a selected tissue and method of use is provided. Imaging, and treatment assemblies may be co-located at a distal end of a single catheter. The imaging assembly may include at least a portion of a confocal microscope. The treatment assembly may include at least a portion of the imaging assembly. A method of treating a selected tissue is also provided. The method may be performed using a single catheter. The imaging and treatment steps of the method may be performed simultaneously.Type: ApplicationFiled: July 28, 2016Publication date: February 2, 2017Inventors: Frank B. Sachse, Robert W. Hitchcock, Nassir F. Marrouche, Nathan J. Knighton, Chao Huang
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Publication number: 20170027465Abstract: Electrophysiology mapping systems and methods that are used to determine longitudinal and transverse conduction velocities within myocardial tissue. The myocardial tissue can be contacted with at least three non-collinear electrodes. A selected electrical pacing protocol can include at least one pacing wave that is delivered to the at least three non-collinear electrodes. During each pacing wave, at least one pair of adjacent electrodes can generate an electrical activation pattern, and at least one additional electrode can detect the activation pattern. For each pacing wave, a processor determines a conduction velocity vector associated with the detection of the electrical activation pattern at a corresponding electrode. The processor can determine a singular value decomposition of the conduction velocity vectors determined during the electrical pacing protocol and use the singular value decomposition to determine the longitudinal and transverse conduction velocities within the myocardial tissue.Type: ApplicationFiled: August 1, 2016Publication date: February 2, 2017Inventors: JOSH E. BLAUER, NASSIR F. MARROUCHE, RAVI RANJAN
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Publication number: 20150238781Abstract: A method of treating hypertension in a mammal is described, including: by focused sound energy, heating at least one nerve at a surface of a renal artery in a mammal; during the heating and by magnetic resonance imaging, repeatedly determining thermal levels in each of first and second volumetric zones of a region that includes at least a portion of the surface, the second zone being adjacent to the first zone; after determining that an indicium of a thermal level in the first zone exceeds a first threshold, and upon determining that an indicium of a thermal level in the second zone exceeds a second threshold, ceasing the heating of the at least one nerve for at least three months; and as a result of the heating, lowering a blood pressure in the mammal.Type: ApplicationFiled: May 11, 2015Publication date: August 27, 2015Inventors: Nassir F. MARROUCHE, Dennis L. PARKER, Allison PAYNE
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Patent number: 9028470Abstract: A method of treating hypertension in a mammal is described, including: by focused sound energy, heating at least one nerve at a surface of a renal artery in a mammal; during the heating and by magnetic resonance imaging, repeatedly determining thermal levels in each of first and second volumetric zones of a region that includes at least a portion of the surface, the second zone being adjacent to the first zone; after determining that an indicium of a thermal level in the first zone exceeds a first threshold, and upon determining that an indicium of a thermal level in the second zone exceeds a second threshold, ceasing the heating of the at least one nerve for at least three months; and as a result of the heating, lowering a blood pressure in the mammal.Type: GrantFiled: June 15, 2012Date of Patent: May 12, 2015Assignee: University of Utah Research FoundationInventors: Nassir F. Marrouche, Dennis L. Parker
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SYSTEM FOR HIGH RESOLUTION FAST ACQUISITION MAGNETIC RESONANCE IMAGING USING A CATHETER-MOUNTED COIL
Publication number: 20150099965Abstract: A catheter-mounted, expandable or set in position, coil for magnetic resonance imaging. The coil having a catheter sheath including an elongated tube with a central axis, the catheter sheath having an opening at an end thereof; an expandable coil including a conductive material connected to an expansion mechanism which, when deployed, maintains the expandable receive coil shape; and a cable running through the catheter sheath, the cable being electrically connected to the coil inductive loop.Type: ApplicationFiled: October 7, 2014Publication date: April 9, 2015Inventors: Nelly A. Volland, J. Rock Hadley, Dennis Lee Parker, Evgueni G. Kholmovski, Robb Phillip Merrill, Nassir F. Marrouche -
Publication number: 20140378822Abstract: A method of optimizing scan parameters for LGE-MRI. At least one cardiac MRI TI scout scan is performed by applying an inversion pulse every predetermined heart beat of a patient. An initial value of an inversion time TIinitial is determined by assessing a set of images generated from the scout scan. A first multiple of a duration between successive indicia of ventricular depolarization is selected, and a relaxation time T1 is determined based on the initial value TIinitial and the first multiple of duration. An optimized inversion time TIoptimal for LGE-MRI is determined based on the relaxation time T1 and a second multiple of a duration between successive indicia of ventricular depolarization. A correction factor is determined based on the optimized inversion time TIoptimal from the initial value of the inversion time TIinitial.Type: ApplicationFiled: October 30, 2012Publication date: December 25, 2014Inventors: Nassir F. Marrouche, Evgueni G. Kholmovski
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Publication number: 20140275972Abstract: A method of monitoring a position of a catheter tip relative to a target tissue. The method includes steps of identifying a wall structure in the target tissue; guiding a catheter towards the wall structure; monitoring a location of the catheter; directing a navigator beam towards the wall structure; aligning the navigator beam with the location of the catheter; monitoring a position of the wall structure using the navigator beam; and determining the position of the wall structure relative to the location of the catheter.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: Ashvin Kurian George, Evgueni G. Kholmovski, Nassir F. Marrouche
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Publication number: 20130023862Abstract: A method of treating hypertension in a mammal is described, including: by focused sound energy, heating at least one nerve at a surface of a renal artery in a mammal; during the heating and by magnetic resonance imaging, repeatedly determining thermal levels in each of first and second volumetric zones of a region that includes at least a portion of the surface, the second zone being adjacent to the first zone; after determining that an indicium of a thermal level in the first zone exceeds a first threshold, and upon determining that an indicium of a thermal level in the second zone exceeds a second threshold, ceasing the heating of the at least one nerve for at least three months; and as a result of the heating, lowering a blood pressure in the mammal.Type: ApplicationFiled: June 15, 2012Publication date: January 24, 2013Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: Nassir F. MARROUCHE, Dennis L. PARKER