Patents by Inventor Nata{haeck over (s)}a Hafner Mila{haeck over (c)}

Nata{haeck over (s)}a Hafner Mila{haeck over (c)} has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process of synthesis of 5-methoxy- 2-[(4-methoxy-3,5-dimethy-2-pyridyl)methyl]sulfiny-1h-benzimidazole
    Patent number: 6268502
    Abstract: An improved process of synthesis of 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl-1H-benzimidazole (omeprazole) by oxidation of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole with 3-chloroperoxy-benzoic acid in ethyl acetate wherein omeprazole is poorly soluble, at a temperature between −10° C. and 5° C. is disclosed. The second step is a purification of the crude product by dissolution and reprecipitation of the final product.
    Type: Grant
    Filed: August 30, 2000
    Date of Patent: July 31, 2001
    Assignee: LEK, Tovarna Farmacevtskih in Kemicnih Izdelkov. D.D.
    Inventors: Nata{haeck over (s)}a Hafner Mila{haeck over (c)}, Darja Jereb