Patents by Inventor Natailia Stoicheva

Natailia Stoicheva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and compositions for high efficiency loading, transfection and fusion of cells by electric pulses
    Patent number: 5789213
    Abstract: Methods and compositions are provided for use in electroloading procedures to increase the transfection and fusion efficiency compared to the methods now used in the art. The compositions comprise a two-phase polymer system containing two water soluble polymers which, when mixed, result in target cells and biological material being encapsulated into one of the polymer phases in a concentrated form. The methods of the present invention for electroloading biological material into target cells comprises mixing the biological material into one of the phases of the two-phase polymer system; mixing the target cells into either of the phases of the two-phase polymer system; mixing the phases together to form an emulsion; and exposing the emulsion to a pulsing electric field in an electroloading process.
    Type: Grant
    Filed: May 11, 1995
    Date of Patent: August 4, 1998
    Assignee: Health Research Inc.
    Inventors: Sek Wen Hui, Natailia Stoicheva, Ya-Li Zhao