Patents by Inventor Natale Alvaro BARBUGIAN

Natale Alvaro BARBUGIAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of diseases through administration of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
    Patent number: 9649306
    Abstract: The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: May 16, 2017
    Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Natale Alvaro Barbugian, Romualdo Forino, Tiziano Fumagalli, Paolo Orsini
  • PROCESS FOR THE PREPARATION OF N-[5-(3,5-DIFLUORO-BENZYL)-1H-INDAZOL-3-YL]-4-(4-METHYL-PIPERAZIN-1-YL)-2-(TETRAHYDRO-PYRAN-4-YLAMINO)-BENZAMIDE
    Publication number: 20160279125
    Abstract: The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention.
    Type: Application
    Filed: June 3, 2016
    Publication date: September 29, 2016
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Natale Alvaro Barbugian, Romualdo Forino, Tiziano Fumagalli, Paolo Orsini
  • Unsolvated crystalline form 1 of N-[5-(3, 5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide and methods of use thereof
    Patent number: 9382235
    Abstract: The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H -indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: July 5, 2016
    Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Natale Alvaro Barbugian, Romualdo Forino, Tiziano Fumagalli, Paolo Orsini
  • PROCESS FOR THE PREPARATION OF N-[5-(3,5-DIFLUORO-BENZYL)-1H-INDAZOL-3-YL]-4-(4-METHYL-PIPERAZIN-1-YL)-2-(TETRAHYDRO-PYRAN-4-YLAMINO)-BENZAMIDE
    Publication number: 20150274707
    Abstract: The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention.
    Type: Application
    Filed: May 20, 2015
    Publication date: October 1, 2015
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Natale Alvaro Barbugian, Romualdo Forino, Tiziano Fumagalli, Paolo Orsini
  • Process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
    Patent number: 9085565
    Abstract: The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: July 21, 2015
    Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Natale Alvaro Barbugian, Romualdo Forino, Tiziano Fumagalli, Paolo Orsini
  • PROCESS FOR THE PREPARATION OF N-[5-(3,5-DIFLUORO-BENZYL)-1H-INDAZOL-3-YL]-4-(4-METHYL-PIPERAZIN-1-YL)-2-(TETRAHYDRO-PYRAN-4-YLAMINO)-BENZAMIDE
    Publication number: 20150051222
    Abstract: The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention.
    Type: Application
    Filed: October 30, 2014
    Publication date: February 19, 2015
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Natale Alvaro BARBUGIAN, Romualdo FORINO, Tiziano FUMAGALLI, Paolo ORSINI
  • CRYSTALLINE NEMORUBICIN HYDROCHLORIDE
    Publication number: 20100069317
    Abstract: This invention relates to a novel crystalline polymorphic form of nemorubicin hydrochloride dihydrate, useful for the preparation of pharmaceutical composition for the treatment of tumors. A process for preparing this novel polymorphic form, named form A, is within the scope of the present invention.
    Type: Application
    Filed: June 29, 2007
    Publication date: March 18, 2010
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Romualdo FORINO, Natale Alvaro BARBUGIAN, Attilio TOMASI, Giuseppina VISENTIN, Marco CATTANEO, Massimo ZAMPIERI