Patents by Inventor Natale Barbugian

Natale Barbugian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isotope labeled camptothecin derivatives
    Publication number: 20060281776
    Abstract: The present invention provides isotope stable labeled camaptothecin analogs including irinotecan and SN-38, a process for their preparation and their use as internal standard in analytical methods.
    Type: Application
    Filed: December 19, 2003
    Publication date: December 14, 2006
    Inventors: Danilo Giribone, Romualdo Forino, Natale Barbugian, Erminia Fontana
  • Crystalline polymorphic form of irinotecan hydrochloride
    Publication number: 20060046993
    Abstract: This invention relates to a novel crystalline polymorphic form of irinotecan hydrochloride. A process for preparing this novel polymorphic form, pharmaceutical compositions comprising it as an active ingredient and the use of the same and its pharmaceutical compositions as a therapeutic agent is also within the scope of the present invention.
    Type: Application
    Filed: September 1, 2004
    Publication date: March 2, 2006
    Applicant: Pharmacia Italia S.p.A.
    Inventors: Romualdo Forino, Natale Barbugian, Massimo Zampieri, Attilio Tomasi
  • Process for the preparation of 4-amino-unsaturated androstanedione derivatives
    Patent number: 5241090
    Abstract: 4-amino-unsaturated androstanedione derivatives provided with aromatase inhibitory activity are obtained by hydrolyzation of a corresponding compound of formula II ##STR1##
    Type: Grant
    Filed: May 20, 1992
    Date of Patent: August 31, 1993
    Assignee: Farmitalia Carlo Erba S.R.L.
    Inventors: Fabrizio Orzi, Antonio Longo, Matteo D'Anello, Natale Barbugian
  • Substituted androsta-1,4-diene-3,17-diones
    Patent number: 4904650
    Abstract: The invention relates to 6-alkylidenadrosta-1,4-diene-3,17-dione derivatives, having the following general formula ##STR1## wherein each of R and R.sub.2, independently, is hydrogen or C.sub.1 -C.sub.6 alkyl and R.sub.1 is hydrogen, halogen or C.sub.1 -C.sub.6 alkyl, which are useful in therapy, in particular in the treatment of hormone-dependent cancers.
    Type: Grant
    Filed: July 26, 1988
    Date of Patent: February 27, 1990
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Franco Buzzetti, Natale Barbugian, Paolo Lombardi, Enrico di Salle
  • 6- or 7-methylenandrosta-1,4-diene-3,17-dione derivatives and process for their preparation
    Patent number: 4824830
    Abstract: The invention relates to new 6- or 7-methylenandrosta-1,4-diene-3,17-diones of the following formula ##STR1## wherein R is hydrogen or fluorine; R.sub.1 is hydrogen or C.sub.1 -C.sub.6 alkyl; R.sub.2 is hydrogen or halogen; one of R.sub.3 and R.sub.4 is .dbd.CH.sub.2 and the other is hydrogen or C.sub.1 -C.sub.4 alkyl, and when R.sub.3 is .dbd.CH.sub.2, at least one of R and R.sub.4 is other than hydrogen; and the symbol ##STR2## represents a double bond and the symbol ##STR3## represents a single bond when R.sub.3 is .dbd.CH.sub.2 or the symbol ##STR4## represents a single bond and the symbol ##STR5## represents a double bond when R.sub.4 is .dbd.CH.sub.2, which are useful in therapy, in particular as anti-cancer agents.
    Type: Grant
    Filed: July 7, 1987
    Date of Patent: April 25, 1989
    Assignee: Farmitalia Carlo Erba S.r.l.
    Inventors: Franco Buzzetti, Natale Barbugian, Paolo Lombardi, Enrico di Salle
  • 6-substituted androsta-1,4-diene-3,17-diones
    Patent number: 4808616
    Abstract: The invention relates to 6-alkylidenandrosta-1,4-diene-3,17-dione derivatives, having the following general formula ##STR1## wherein each of R and R.sub.2, independently, is hydrogen or C.sub.1 -C.sub.6 alkyl and R.sub.1 is hydrogen, halogen or C.sub.1 -C.sub.6 alkyl, which are useful in therapy, in particular in the treatment of hormone-dependent cancers.
    Type: Grant
    Filed: July 7, 1986
    Date of Patent: February 28, 1989
    Assignee: Farmitalia Carlo Erba S.r.l.
    Inventors: Franco Buzzetti, Natale Barbugian, Paolo Lombardi, Enrico di Salle