Abstract: The invention relates to a novel chemical compound—a diagnostic marker—for use in medicine, more specifically in cancer diagnosis, in particular the diagnosis of lung cancer. The invention also relates to an in vitro method for detecting enzymatic activity present in a subject's body fluid, in particular derived from lung cancer cells, using the compound. The invention further relates to an in vitro method for diagnosing lung cancer using the compound, a kit comprising the compound and use of the compound for the detection of enzymatic activity specific to lung cancer and use of the compound for the diagnosis of lung cancer. The invention also relates to the compound for use as a diagnostic marker of lung cancer and a method for the treatment of lung cancer comprising a step of carrying out the method for the diagnosis of lung cancer as defined above using the compound.

Abstract: The invention relates to a novel chemical compound—a diagnostic marker—for use in medicine, more specifically in cancer diagnosis, in particular the diagnosis of liver cancer. The invention also relates to an in vitro method for detecting enzymatic activity present in a subject's body fluid, in particular derived from liver cancer cells, using the compound. The invention further relates to an in vitro method for diagnosing liver cancer using the compound, a kit comprising the compound and use of the compound for the detection of enzymatic activity specific to liver cancer and use of the compound for the diagnosis of liver cancer. The invention also relates to the compound for use as a diagnostic marker of liver cancer and a method for the treatment of liver cancer comprising a step of carrying out the method for the diagnosis of liver cancer as defined above using the compound.

Abstract: The invention provides a compound characterized by formula 1: X1-Trp-Glu-Gly-Asn-X2, wherein cleavage of the compound into a fragment 1 comprising X1 and a fragment 2 comprising X2 generates a detectable signal. The invention further provides an in vitro method for detecting protease activity in a subject's body fluid, comprising contacting the body fluid with the compound of the invention and detecting a signal, wherein the body fluid may comprise a hydrolytic enzyme derived from prostate cancer cells. Furthermore, the invention provides a kit comprising the compound of the invention and a measurement buffer. In addition, the invention provides the use of the compound, the in vitro method or the kit of the invention for the detection of prostate cancer, or for monitoring a subject that is suspected of having prostate cancer, has an increased risk of developing prostate cancer, or has had prostate cancer.

Abstract: The invention provides a compound characterized by formula (1): X1-Thr-Thr-Ala-Arg-X2, wherein cleavage of the compound into a fragment 1 comprising X1 and a fragment 2 comprising X2 generates a detectable signal. The invention further provides an in vitro method for detecting protease activity in a subject's body fluid, comprising contacting the body fluid with the compound of the invention and detecting a signal, wherein the body fluid may comprise a hydrolytic enzyme derived from pancreatic cancer cells. Furthermore, the invention provides a kit comprising the compound of the invention and a measurement buffer. In addition, the invention provides the use of the compound, the in vitro method or the kit of the invention for the detection of pancreatic cancer, or for monitoring a subject that is suspected of having pancreatic cancer, has an increased risk of developing pancreatic cancer, or has had pancreatic cancer.