Abstract: Provided are a diagnostic system and methods for detecting the presence or absence of one or more targets that represent virus infection, inflammatory diseases and/or respiratory disorders by optically and noninvasively observing changing in color of the diagnostic system upon binding of the antigen of interest. Exemplary diagnostic systems and methods include detection of SARS-CoV-2 virus S protein or receptor of advanced glycation end products (RAGE) for diagnosis of COVID-19 infection or inflammatory/respiratory diseases.

Abstract: A method for diagnosing cancer by obtaining secretome from a cell culture from peripheral blood. A non-hematological cell component present in peripheral blood is allowed to expand in the cell culture and a measurement of channel current I(t) at a measurement point is performed in a channel of conductive polymer located between first and second electrodes, the channel being arranged to act as a conducting channel of a transistor and being connected to a gate electrode of the transistor through the secretome. A modulation m, given by final intensity Ids of channel current normalized with respect to initial intensity Ids0, and a time constant ? given by the time it takes for the channel current I(t) to reach a predetermined percentage of the final intensity Ids are obtained. The m and ? values are indicative of protonation state of the secretome and, on the basis of the values, the secretome is classified as being from a healthy individual, an individual having cancer, or an individual at risk for cancer.

Abstract: The present invention relates to an in vitro method for the diagnosis and/or prognosis of non-haematological tumours by analysing circulating tumour cells isolated from a blood sample or a derivative thereof and to a kit for such purpose. The present invention further relates to a specific culture medium particularly effective for use in such method.