Patents by Inventor Natalia Rodionova
Natalia Rodionova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11708572Abstract: Beads with functionalized material applied to them are exposed to an acoustic field to trap, retain or pass the beads. The beads may include or be free of ferro magnetic material. The beads may be biocompatible or biodegradable for a host. The size of the beads may vary over a range, and/or be heterogenous or homogenous. The composition of the beads may include high, neutral or low acoustic contrast material. The chemistry of the functionalized material may be compatible with existing processes. The acoustic field may be generated, for example, in an acoustic angled wave device or in an acoustic fluidized bed.Type: GrantFiled: May 23, 2019Date of Patent: July 25, 2023Assignee: FloDesign Sonics, Inc.Inventors: Bart Lipkens, Kedar C. Chitale, Krishna N. Kumar, Walter M. Presz, Jr., Ruan Zhang, Benjamin Ross-Johnsrud, Rudolf Gilmanshin, Natalia Rodionova, Rui Tostoes
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Patent number: 11420136Abstract: Beads with functionalized material applied to them are exposed to an acoustic field to trap or pass the beads. The beads may include or be free of ferro magnetic material. The beads may be biocompatible or biodegradable for a host. The size of the beads may vary over a range, and/or be heterogenous or homogenous. The composition of the beads may include high, neutral or low acoustic contrast material. The chemistry of the functionalized material may be compatible with existing processes.Type: GrantFiled: October 19, 2017Date of Patent: August 23, 2022Assignee: FloDesign Sonics, Inc.Inventors: Bart Lipkens, Rudolf Gilmanshin, Natalia Rodionova, Benjamin Ross-Johnsrud
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Publication number: 20190345477Abstract: Beads with functionalized material applied to them are exposed to an acoustic field to trap, retain or pass the beads. The beads may include or be free of ferro magnetic material. The beads may be biocompatible or biodegradable for a host. The size of the beads may vary over a range, and/or be heterogenous or homogenous. The composition of the beads may include high, neutral or low acoustic contrast material. The chemistry of the functionalized material may be compatible with existing processes. The acoustic field may be generated, for example, in an acoustic angled wave device or in an acoustic fluidized bed.Type: ApplicationFiled: May 23, 2019Publication date: November 14, 2019Inventors: Bart Lipkens, Kedar C. Chitale, Krishna N. Kumar, Walter M. Presz, JR., Ruan Zhang, Benjamin Ross-Johnsrud, Rudolf Gilmanshin, Natalia Rodionova, Rui Tostoes
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Publication number: 20180104620Abstract: Beads with functionalized material applied to them are exposed to an acoustic field to trap or pass the beads. The beads may include or be free of ferro magnetic material. The beads may be biocompatible or biodegradable for a host. The size of the beads may vary over a range, and/or be heterogenous or homogenous. The composition of the beads may include high, neutral or low acoustic contrast material. The chemistry of the functionalized material may be compatible with existing processes.Type: ApplicationFiled: October 19, 2017Publication date: April 19, 2018Inventors: Bart Lipkens, Rudolf Gilmanshin, Natalia Rodionova, Benjamin Ross-Johnsrud
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Patent number: 8986983Abstract: Cassette (50) performs assays, e.g. multiplexed protein biomarker assays. Wide, bubble-free, slow flows are produced from liquids stored on cassette (50), flowing over wide array (20) of ligand receptors on a capture surface. Flows of Reynolds Number less than about 1, preferably 1×10?1 to 5×10?3, are heated in region (34) preceding and including bubble removal system (128). Analyte is introduced through compressed septum (32). External actuations of displacement pumps (30, 37) and valves (137 A, B, and C) produce flows in response to flow-front optical sensors (150, 152). Elastic sheet provides pump and valve diaphragms and resilient expansion of mixing volume (131). Break-away cover portions are pistons. Heating is by conduction through cassette from external contact heater. Planar cassette body, when tilted from horizontal, enables upward flow from pumped storage (134, 135) to reaction (133) to waste (139), with buoyancy bubble removal before reaction.Type: GrantFiled: September 7, 2010Date of Patent: March 24, 2015Assignee: Courtagen Life Sciences, Inc.Inventors: Jean I. Montagu, Herman Deweerd, Roger Dowd, Natalia Rodionova, Peter Maimonis, Nathan Tyburczy
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Publication number: 20110319279Abstract: Cassette (50) performs assays, e.g. multiplexed protein biomarker assays. Wide, bubble-free, slow flows are produced from liquids stored on cassette (50), flowing over wide array (20) of ligand receptors on a capture surface. Flows of Reynolds Number less than about 1, preferably 1×10?1 to 5×10?3, are heated in region (34) preceding and including bubble removal system (128). Analyte is introduced through compressed septum (32). External actuations of displacement pumps (30, 37) and valves (137 A, B, and C) produce flows in response to flow-front optical sensors (150, 152). Elastic sheet provides pump and valve diaphragms and resilient expansion of mixing volume (131). Break-away cover portions are pistons. Heating is by conduction through cassette from external contact heater. Planar cassette body, when tilted from horizontal, enables upward flow from pumped storage (134, 135) to reaction (133) to waste (139), with buoyancy bubble removal before reaction.Type: ApplicationFiled: September 7, 2010Publication date: December 29, 2011Applicant: AVANTRA BIOSCIENCES CORPORATIONInventors: Jean I. Montagu, Herman Deweerd, Roger Dowd, Natalia Rodionova, Peter Maimonis, Nathan Tyburczy
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Publication number: 20110207621Abstract: Flow-through assay reaction chamber (6) of cassette has back and forth liquid mixing in narrow gap (G) over array of capture agent (S), with net flow advance to waste confinement (19), produced by reversible pumps (3 or 12), operable with rolling diaphragm action with at least limited elastic recovery that advance sample or buffer liquids through conditioning paths (4A, 8, 8?, 9, 14, 15, 15?) before reaching the reaction chamber (6). A single pump produces accurate flow control, liquid conditioning, e.g., liquefying dry reagent from internal surfaces of flow-dividing material (14a, 15A, 15A?, e.g. open cell foam or frit), heating (4A), and air bubble removal (8, 8?, 9), as well as replenishment of reagent while accomplishing mixing within the flow-through reaction chamber (6). Lower viscosity buffer liquid is arranged to propel higher viscosity reagent, the flow-dividing storage material preserving reagent concentration.Type: ApplicationFiled: February 20, 2009Publication date: August 25, 2011Applicant: AVANTRA BIOSCIENCES CORPORATIONInventors: Jean I. Montagu, Herman Deweerd, Natalia A. Rodionova, Nathan Tyburczy
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Publication number: 20080026373Abstract: Assays based on probes attached to surfaces enclosed within cassettes and cassettes and reading stations for the assays. After liquids flow over the probe or probe array to form an array of photo-emissive analyte complexes, and prior to reading, (a) liquid is removed by flow, and (b) a drying gas stream, is forced into the cassette and over the complexes for a drying interval to remove liquid residue. Heating assists the drying. Light from the analyte complexes is then read through a window of the cassette. The interval of drying may be of the order of about one minute. During a preceding wash phase, gas flow bursts through the gas inlet channel purge liquid contaminant. The probes e.g. may be oligonucleotides, peptides, polypeptides, proteins, antibodies, or small molecules (steroids, expression regulators, e.g. siRNA, or other ligands). A cassette has a passage leading from a bubble removal system to the probe-bearing surface and the desiccating gas stream is introduced to that passage.Type: ApplicationFiled: July 26, 2006Publication date: January 31, 2008Inventor: Natalia A. Rodionova
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Publication number: 20060275852Abstract: Cassette (50) performs assays, e.g. multiplexed protein biomarker assays. Wide, bubble-free, slow flows are produced from liquids stored on cassette (50), flowing over wide array (20) of ligand receptors on a capture surface. Flows of Reynolds Number less than about 1, preferably 1×10?1 to 5×10?3, are heated in region (34) preceding and including bubble removal system (128). Analyte is introduced through compressed septum (32). External actuations of displacement pumps (30, 37) and valves (137 A, B, and C) produce flows in response to flow-front optical sensors (150, 152). Elastic sheet provides pump and valve diaphragms and resilient expansion of mixing volume (131). Break-away cover portions are pistons. Heating is by conduction through cassette from external contact heater. Planar cassette body, when tilted from horizontal, enables upward flow from pumped storage (134, 135) to reaction (133) to waste (139), with buoyancy bubble removal before reaction.Type: ApplicationFiled: October 27, 2005Publication date: December 7, 2006Inventors: Jean Montagu, Herman Deweerd, Roger Dowd, Natalia Rodionova, Peter Maimonis, Nathan Tyburczy