Patents by Inventor Natalie A. Lokker

Natalie A. Lokker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hepatocyte growth factor protease domain variants
    Patent number: 5879910
    Abstract: The invention concerns hepatocyte growth factor (HGF) variants that compise an amino acid alteration at a site within the protease domain of HGF and retaining substantially full receptor binding affinity of the corresponding wild-type HGF.
    Type: Grant
    Filed: February 9, 1994
    Date of Patent: March 9, 1999
    Assignee: Genetech, Inc.
    Inventors: Paul J. Godowski, Natalie A. Lokker, Melanie R. Mark
  • Single-chain hepatocyte growth factor variants
    Patent number: 5580963
    Abstract: The invention concerns hepatocyte growth factor (HGF) variants that are resistant to proteolytic cleavage by enzymes capable of in vivo conversion of HGF into its two-chain form. The single-chain HGF variants, which preferably have an amino acid alteration at or adjacent to any of amino acid positions 493, 494, 495 and 496 of the wild-type human HGF sequence, retain their ability to bind the HGF receptor.
    Type: Grant
    Filed: February 9, 1994
    Date of Patent: December 3, 1996
    Assignee: Genentech, Inc.
    Inventors: Paul J. Godowski, Natalie A. Lokker, Melanie R. Mark
  • Hepatocyte growth factor variants
    Patent number: 5547856
    Abstract: The invention concerns hepatocyte growth factor (HGF) amino acid sequence variants. The preferred variants are resistant to proteolytic cleavage by enzymes capable of in vivo conversion of HGF into its two-chain form and/or contain a mutation within the protease domain of HGF.
    Type: Grant
    Filed: July 13, 1993
    Date of Patent: August 20, 1996
    Assignee: Genentech, Inc.
    Inventors: Paul J. Godowski, Natalie A. Lokker, Melanie R. Mark
  • Hepatocyte growth factor protease domain variants
    Patent number: 5328837
    Abstract: The invention concerns hepatocyte growth factor (HGF) variants that compise an amino acid alteration at a site within the protease domain of HGF and retaining substantially full receptor binding affinity of the corresponding wild-type HGF.
    Type: Grant
    Filed: May 18, 1992
    Date of Patent: July 12, 1994
    Assignee: Genentech, Inc.
    Inventors: Paul J. Godowski, Natalie A. Lokker, Melanie R. Mark
  • Single-chain hepatocyte growth factor variants
    Patent number: 5316921
    Abstract: The invention concerns hepatocyte growth factor (HGF) variants that are resistant to proteolytic cleavage by enzymes capable of in vivo conversion of HGF into its two-chain form. The single-chain HGF variants, which preferably have an amino acid alteration at or adjacent to any of amino acid positions 493, 494, 495 and 496 of the wild-type human HGF sequence, retain their ability to bind the HGF receptor.
    Type: Grant
    Filed: May 18, 1992
    Date of Patent: May 31, 1994
    Assignee: Genentech, Inc.
    Inventors: Paul J. Godowski, Natalie A. Lokker, Melanie R. Mark