Patents by Inventor Natalie Grinshtein

Natalie Grinshtein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EGFR-CMET-TARGETED COMPOUNDS AND USES THEREOF
    Publication number: 20250121104
    Abstract: Compounds, e.g., radioimmunoconjugates, including a chelating moiety or a metal complex thereof, a linker, and an antibody or antigen-binding fragment thereof targeting both EGFR and cMET. Pharmaceutical compositions of such compounds and methods of treatment for conditions, e.g., cancer, using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: December 20, 2022
    Publication date: April 17, 2025
    Inventors: Sadaf AGHEVLIAN, Natalie GRINSHTEIN, Ian R. DUFFY, Thomas I. KOSTELINK, Andrew Grier BUCHANAN, Yariv MAZOR, Srinath KASTURIRANGAN, Qun DU, Chunning YANG, Frank Irvine COMER
  • PSMA-TARGETED RADIOPHARMACEUTICALS AND CHECKPOINT INHIBITOR COMBINATION THERAPY
    Publication number: 20250114488
    Abstract: Combination therapies comprising administering PSMA-targeted radiopharmaceuticals and one or more checkpoint inhibitors
    Type: Application
    Filed: January 27, 2023
    Publication date: April 10, 2025
    Inventors: Natalie Grinshtein, Shekoufeh Almasi, Saleemulla Mahammad
  • NTSR1-TARGETED RADIOPHARMACEUTICALS AND CHECKPOINT INHIBITOR COMBINATION THERAPY
    Publication number: 20250099633
    Abstract: Methods for treating or ameliorating cancer comprising administering to a mammal a NTSR-1 targeted radiopharmaceutical comprising a radionuclide chelated to a compound of formula I, and one or more checkpoint inhibitors.
    Type: Application
    Filed: January 27, 2023
    Publication date: March 27, 2025
    Inventors: Natalie Grinshtein, Saleemulla Mahammad, Maria Audrey Jaline Llanto Broqueza
  • EGFRVIII-TARGETED COMPOUNDS AND USES THEREOF
    Publication number: 20240408249
    Abstract: Compounds, e.g., radioimmunoconjuguates including a chelating moiety or a metal complex thereof, a linker, and an EGFRVIII targeting moiety. Pharmaceutical compositions of such compounds and methods of treatment for conditions. e.g., cancer, using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: September 29, 2022
    Publication date: December 12, 2024
    Inventors: Natalie Grinshtein, Julie Metcalf, Ian R. Duffy, William Leslie Turnbull, Anne Marcil, Maria Jaramillo, Traian Sulea, Maria Moreno, Cunle Wu
  • RADIOIMMUNOCONJUGATES AND CHECKPOINT INHIBITOR COMBINATION THERAPY
    Publication number: 20240285818
    Abstract: Combination therapies comprising administering radioimmunoconjugates and one or more checkpoint inhibitors.
    Type: Application
    Filed: June 10, 2022
    Publication date: August 29, 2024
    Inventors: Eric Steven Burak, Julie Metcalf, John Fitzmaurice Valliant, Meiduo Hu, Natalie Grinshtein
  • METHODS OF TREATING CANCER
    Publication number: 20240139353
    Abstract: Methods of treatment for conditions, e.g., cancer, using a cold FGFR3-targeting molecule and a radioimmunoconjugate comprising a chelating moiety or a metal complex thereof, a linker, and an FGFR3 targeting moiety.
    Type: Application
    Filed: March 23, 2022
    Publication date: May 2, 2024
    Inventors: Natalie Grinshtein, Yaryna Storozhuk
  • RADIOIMMUNOCONJUGATES AND CHECKPOINT INHIBITOR COMBINATION THERAPY
    Publication number: 20230270895
    Abstract: Combination therapies comprising administering radioimmunoconjugates and one or more checkpoint inhibitors.
    Type: Application
    Filed: August 15, 2022
    Publication date: August 31, 2023
    Inventors: Eric Steven Burak, Julie Metcalf, Natalie Grinshtein, Meiduo Hu, John Fitzmaurice Valliant
  • FGFR3-TARGETED RADIOIMMUNOCONJUGATES AND USES THEREOF
    Publication number: 20230201384
    Abstract: Radioimmunoconjugates including a chelating moiety or a metal complex thereof, a linker, and an FGFR3 targeting moiety. Pharmaceutical compositions of such radioimmunoconjugates and methods of treatment for conditions, e.g., cancer, using such pharmaceutical compositions.
    Type: Application
    Filed: March 23, 2021
    Publication date: June 29, 2023
    Inventors: Eric Steven Burak, Marc Schwabish, Natalie Grinshtein
  • SUSTAINED IMMUNOTHERAPY
    Publication number: 20230091468
    Abstract: Methods of inducing CD8+ T cell infiltration into a tumor in a patient in need thereof comprising administering a radioimmunoconjugate that is capable of binding a target expressed by at least some cells in a tumor.
    Type: Application
    Filed: January 8, 2021
    Publication date: March 23, 2023
    Inventors: Eric Steven Burak, julie Metcalf, Natalie Grinshtein, Meiduo Hu, John Fitznaurice valliant, Sonal Patel
  • Actinium-225 and checkpoint inhibitor combination therapy
    Patent number: 11446401
    Abstract: Combination therapies comprising administering radioimmunoconjugates and one or more checkpoint inhibitors.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: September 20, 2022
    Assignee: Fusion Pharmaceuticals Inc.
    Inventors: Eric Steven Burak, Julie Metcalf, Natalie Grinshtein, Meiduo Hu, John Fitzmaurice Valliant
  • RADIOIMMUNOCONJUGATES AND CHECKPOINT INHIBITOR COMBINATION THERAPY
    Publication number: 20220088230
    Abstract: Combination therapies comprising administering radioimmunoconjugates and one or more checkpoint inhibitors.
    Type: Application
    Filed: December 3, 2019
    Publication date: March 24, 2022
    Inventors: Eric Steven BURAK, Julie METCALF, Natalie GRINSHTEIN, Meiduo HU, John Fitzmaurice VALLIANT
  • RADIOIMMUNOCONJUGATES AND CHECKPOINT INHIBITOR COMBINATION THERAPY
    Publication number: 20210290789
    Abstract: Combination therapies comprising administering radioimmunoconjugates and one or more checkpoint inhibitors.
    Type: Application
    Filed: June 2, 2021
    Publication date: September 23, 2021
    Inventors: Eric Steven Burak, Julie Metcalf, Natalie Grinshtein, Meiduo Hu, John Fitzmaurice Valliant