Abstract: The invention relates to barcoded nucleic acid nanostructure delivery compositions for in vivo screening for subsequent use in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to nucleic acid nanostructure delivery compositions, such as DNA origami structures, associated with barcodes for high throughput in vivo screening of the nucleic acid nanostructure delivery compositions for subsequent use in drug delivery, and methods therefor.

Abstract: The present disclosure provides binding proteins and TCRs with high affinity and specificity against Merkel cell polyomavirus T antigen epitopes or peptides, T cells expressing such high affinity Merkel cell polyomavirus T antigen specific TCRs, nucleic acids encoding the same, and compositions for use in treating Merkel cell carcinoma.

Abstract: The present disclosure provides binding proteins and TCRs with high affinity and specificity against Merkel cell Poly-omavirus T antigen epitopes or peptides, T cells expressing such high affinity Merkel cell polyomavirus T antigen specific TCRs, nucleic acids encoding the same, and compositions for use in treating Merkel cell carcinoma.

Abstract: Embodiments disclosed herein generally relate to techniques for providing a visualization of connectivity between components in a computer network. One embodiment provides a method which includes receiving a configuration of a network comprising a plurality of components within a physical layer and a virtual layer. The method also includes generating a resource diagram identifying connections that are accessible among the components of the physical layer and components of the virtual layer. The method further includes, upon receiving a selection of one of the components, determining a subset of the plurality of components that are connected to the selected component, and altering the resource diagram to provide a visualization, within the resource diagram, of the connections between the selected component and the determined subset of the plurality of components.

Abstract: Embodiments disclosed herein generally relate to techniques for providing a visualization of connectivity between components in a computer network. One embodiment provides a method which includes receiving a configuration of a network comprising a plurality of components within a physical layer and a virtual layer. The method also includes generating a resource diagram identifying connections that are accessible among the components of the physical layer and components of the virtual layer. The method further includes, upon receiving a selection of one of the components, determining a subset of the plurality of components that are connected to the selected component, and altering the resource diagram to provide a visualization, within the resource diagram, of the connections between the selected component and the determined subset of the plurality of components.

Abstract: Embodiments disclosed herein generally relate to techniques for providing a visualization of connectivity between components in a computer network. One embodiment provides a method which includes receiving a configuration of a network comprising a plurality of components within a physical layer and a virtual layer. The method also includes generating a resource diagram identifying connections that are accessible among the components of the physical layer and components of the virtual layer. The method further includes, upon receiving a selection of one of the components, determining a subset of the plurality of components that are connected to the selected component, and altering the resource diagram to provide a visualization, within the resource diagram, of the connections between the selected component and the determined subset of the plurality of components.

Abstract: Embodiments disclosed herein generally relate to techniques for providing a visualization of connectivity between components in a computer network. One embodiment provides a method which includes receiving a configuration of a network comprising a plurality of components within a physical layer and a virtual layer. The method also includes generating a resource diagram identifying connections that are accessible among the components of the physical layer and components of the virtual layer. The method further includes, upon receiving a selection of one of the components, determining a subset of the plurality of components that are connected to the selected component, and altering the resource diagram to provide a visualization, within the resource diagram, of the connections between the selected component and the determined subset of the plurality of components.