Patents by Inventor Natalie Wisniewski
Natalie Wisniewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11903702Abstract: Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.Type: GrantFiled: September 14, 2020Date of Patent: February 20, 2024Assignee: Profusa, Inc.Inventors: Mary K. Balaconis, Scott Nichols, Sierra Guidry, Yu Zhang, Ryan Schweller, Soya Gamsey, Jacob William Clary, Sulolit Pradhan, Natalie Wisniewski
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Publication number: 20230337951Abstract: Some embodiments described herein relate to an apparatus including a light source configured to transmit an excitation optical signal to an implanted sensor and a detector configured to detect an analyte-dependent optical signal emitted from an implanted sensor. The apparatus can include a lens configured to focus at least a portion of the analyte-dependent optical signal onto the detector.Type: ApplicationFiled: November 18, 2022Publication date: October 26, 2023Applicant: Profusa, Inc.Inventors: Gregory J. KINTZ, William A. MCMILLAN, Natalie A. WISNIEWSKI
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Patent number: 11504035Abstract: Some embodiments described herein relate to an apparatus including a light source configured to transmit an excitation optical signal to an implanted sensor and a detector configured to detect an analyte-dependent optical signal emitted from an implanted sensor. The apparatus can include a lens configured to focus at least a portion of the analyte-dependent optical signal onto the detector.Type: GrantFiled: March 4, 2019Date of Patent: November 22, 2022Assignee: Profusa, Inc.Inventors: Gregory J. Kintz, William A. McMillan, Natalie A. Wisniewski
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Publication number: 20220095960Abstract: An optical device is used to monitor an implant embedded in the tissue of a mammal (e.g., under the skin). The implant receives excitation light from the optical device and emits light that is detected by the optical device, including an analyte-dependent optical signal. Scatter and absorption properties of tissue change over time due to changes in hydration, blood perfusion and oxygenation. The optical device has an arrangement of light sources, filters and detectors to transmit excitation light within excitation wavelength ranges and to measure emitted light within detection wavelengths. Changes in scattering and absorption of light in the tissue, such as diffuse reflectance, are monitored. The light sources, filters and detectors may also be used to monitor autofluorescence in the tissue to correct autofluorescence background.Type: ApplicationFiled: October 4, 2021Publication date: March 31, 2022Applicant: Profusa, Inc.Inventors: Gregory J. KINTZ, William MCMILLAN, Natalie WISNIEWSKI
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Patent number: 11134871Abstract: An optical device is used to monitor an implant embedded in the tissue of a mammal (e.g., under the skin). The implant receives excitation light from the optical device and emits light that is detected by the optical device, including an analyte-dependent optical signal. Scatter and absorption properties of tissue change over time due to changes in hydration, blood perfusion and oxygenation. The optical device has an arrangement of light sources, filters and detectors to transmit excitation light within excitation wavelength ranges and to measure emitted light within detection wavelengths. Changes in scattering and absorption of light in the tissue, such as diffuse reflectance, are monitored. The light sources, filters and detectors may also be used to monitor autofluorescence in the tissue to correct autofluorescence background.Type: GrantFiled: August 13, 2018Date of Patent: October 5, 2021Assignee: Profusa, Inc.Inventors: Gregory J. Kintz, William A. McMillan, Natalie Wisniewski
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Publication number: 20210128035Abstract: Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.Type: ApplicationFiled: September 14, 2020Publication date: May 6, 2021Applicant: Profusa, Inc.Inventors: Mary K. BALACONIS, Scott NICHOLS, Sierra GUIDRY, Yu ZHANG, Ryan SCHWELLER, Soya GAMSEY, Jacob William CLARY, Sulolit PRADHAN, Natalie WISNIEWSKI
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Publication number: 20210093239Abstract: Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.Type: ApplicationFiled: December 8, 2020Publication date: April 1, 2021Applicant: Profusa, Inc.Inventors: Soya GAMSEY, Natalie WISNIEWSKI, Kristen HELTON, William A. MCMILLAN
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Patent number: 10874337Abstract: Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.Type: GrantFiled: July 18, 2019Date of Patent: December 29, 2020Assignee: Profusa, Inc.Inventors: Soya Gamsey, Natalie Wisniewski, Kristen Helton, William A. McMillan
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Publication number: 20200305770Abstract: Tissue-integrating biosensors, systems comprising these sensors and methods of using these sensors and systems for the detection of one or more analytes are provided.Type: ApplicationFiled: November 4, 2019Publication date: October 1, 2020Applicant: Profusa, Inc.Inventors: Natalie A. WISNIEWSKI, Kristen HELTON, William A. MCMILLAN
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Patent number: 10772546Abstract: Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.Type: GrantFiled: June 29, 2018Date of Patent: September 15, 2020Assignee: Profusa, Inc.Inventors: Mary K. Balaconis, Scott Nichols, Sierra Guidry, Yu Zhang, Ryan Schweller, Soya Gamsey, Jacob William Clary, Sulolit Pradhan, Natalie Wisniewski
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Publication number: 20200107762Abstract: Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.Type: ApplicationFiled: July 18, 2019Publication date: April 9, 2020Applicant: Profusa, Inc.Inventors: Soya GAMSEY, Natalie WISNIEWSKI, Kristen HELTON, William A. MCMILLAN
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Patent number: 10583308Abstract: The invention provides methods for directing a localized biological response of a mammalian body to an implant disposed within the body. In one embodiment, a delivery system is positioned outside the body and adjacent to the implant within the body. The delivery system comprises a first tissue response modifier effective for directing a localized biological response of the body to the implant. The tissue response modifier is nonsurgically delivered from the delivery system into the body in a quantity effective to direct the localized biological response of the body to the implant. The invention also provides an implant system for long-term use comprising an implant and nonsurgical means for delivering a tissue response modifier through the epidermis of the body, the tissue response modifier effective for directing a localized biological response of the body to the implant.Type: GrantFiled: December 12, 2016Date of Patent: March 10, 2020Assignee: Profusa, Inc.Inventors: William A. McMillan, Natalie Wisniewski
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Publication number: 20200008716Abstract: Some embodiments described herein relate to an apparatus including a light source configured to transmit an excitation optical signal to an implanted sensor and a detector configured to detect an analyte-dependent optical signal emitted from an implanted sensor. The apparatus can include a lens configured to focus at least a portion of the analyte-dependent optical signal onto the detector.Type: ApplicationFiled: March 4, 2019Publication date: January 9, 2020Applicant: Profusa, Inc.Inventors: Gregory J. KINTZ, William A. MCMILLAN, Natalie A. WISNIEWSKI
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Patent number: 10463287Abstract: Tissue-integrating biosensors, systems comprising these sensors and methods of using these sensors and systems for the detection of one or more analytes are provided.Type: GrantFiled: October 6, 2011Date of Patent: November 5, 2019Assignee: Profusa, Inc.Inventors: Natalie A. Wisniewski, Kristen Helton, William A. McMillan
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Patent number: 10383557Abstract: Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.Type: GrantFiled: December 4, 2017Date of Patent: August 20, 2019Assignee: Profusa, Inc.Inventors: Soya Gamsey, Natalie Wisniewski, Kristen Helton, William A. McMillan
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Publication number: 20190200865Abstract: A system includes implantable sensors and monitors and are operable to provide health-related feedback to users based on data received from the implantable sensors and monitors.Type: ApplicationFiled: December 28, 2018Publication date: July 4, 2019Applicant: Profusa, Inc.Inventors: Ben HWANG, William A. MCMILLAN, Natalie WISNIEWSKI
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Publication number: 20190192057Abstract: An optical device is used to monitor an implant embedded in the tissue of a mammal (e.g., under the skin). The implant receives excitation light from the optical device and emits light that is detected by the optical device, including an analyte-dependent optical signal. Scatter and absorption properties of tissue change over time due to changes in hydration, blood perfusion and oxygenation. The optical device has an arrangement of light sources, filters and detectors to transmit excitation light within excitation wavelength ranges and to measure emitted light within detection wavelengths. Changes in scattering and absorption of light in the tissue, such as diffuse reflectance, are monitored. The light sources, filters and detectors may also be used to monitor autofluorescence in the tissue to correct autofluorescence background.Type: ApplicationFiled: August 13, 2018Publication date: June 27, 2019Applicant: Profusa, Inc.Inventors: Gregory J. KINTZ, William A. MCMILLAN, Natalie WISNIEWSKI
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Patent number: 10219729Abstract: Some embodiments described herein relate to an apparatus including a light source configured to transmit an excitation optical signal to an implanted sensor and a detector configured to detect an analyte-dependent optical signal emitted from an implanted sensor. The apparatus can include a lens configured to focus at least a portion of the analyte-dependent optical signal onto the detector.Type: GrantFiled: June 6, 2014Date of Patent: March 5, 2019Assignee: Profusa, Inc.Inventors: Gregory J. Kintz, William A. McMillan, Natalie A. Wisniewski
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Publication number: 20190029572Abstract: Tissue-integrating electronic apparatuses, systems comprising such apparatuses and methods of using these apparatuses and systems for the detection of one or more signals are provided.Type: ApplicationFiled: June 25, 2018Publication date: January 31, 2019Applicant: Profusa, Inc.Inventors: Natalie A. WISNIEWSKI, Kurt E. PETERSEN, Kristen HELTON, William A. MCMILLAN
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Publication number: 20190000364Abstract: Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.Type: ApplicationFiled: June 29, 2018Publication date: January 3, 2019Inventors: Kate BALACONIS, Scott NICHOLS, Sierra GUIDRY, Yu ZHANG, Ryan SCHWELLER, Soya GAMSEY, Jacob William CLARY, Sulolit PRADHAN, Natalie WISNIEWSKI