Patents by Inventor Natarajan Dhanasekaran

Natarajan Dhanasekaran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biosensor for defecting chemical agents
    Patent number: 7223550
    Abstract: A biosensor for the identification of olfactants, including chemical and biological agents, prefumery, explosives and pharmaceuticals. The biosensors comprise robust eukaryotic cells, such as yeast, into which at least one exogenous olfactory signaling pathway has been genetically integrated to detect molecules of interest.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: May 29, 2007
    Assignee: Temple University-of the Commonwealth System of Higher Education
    Inventors: Natarajan Dhanasekaran, John R. Jenkins
  • Cell-based assay for screening cox-2 inhibitors
    Patent number: 6933128
    Abstract: A cell-based assay is provided for screening substances for the capacity to inhibit COX-2 activity. The assay utilizes as a screening reagent a cell line which has been engineered to achieve constitutive or inducible expression of COX-2. In one embodiment, the cells express a GTPase-deficient, constitutively-activated mutant form of the ?-subunit of protein G12 which induces the production of arachidonic acid and COX-2. Decreased cell proliferation in the presence of test substance indicates that the substance has COX-2 inhibitory activity.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: August 23, 2005
    Assignee: Temple University-of the Commonwealth System of Higher Education
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy, Natarajan Dhanasekaran
  • Biosensor for defecting chemical agents
    Publication number: 20040235060
    Abstract: A biosensor for the identification of olfactants, including chemical and biological agents, perfumery, explosives and pharmaceuticals. The biosensors comprise robust eukaryotic cells, such as yeast, into which at least one exogenous olfactory signaling pathway has been genetically integrated to detect molecules of interest.
    Type: Application
    Filed: June 25, 2004
    Publication date: November 25, 2004
    Inventors: Natarajan Dhanasekaran, John R Jenkins