Patents by Inventor Natarajan Sethuraman

Natarajan Sethuraman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cloning, overexpression and therapeutic use of bioactive histidine ammonia lyase
    Publication number: 20020052038
    Abstract: Histidine ammonia lyase (HAL) isolated from Corynebacteriaceae can decrease serum histidine levels, induce accumulation of urocanic acid, and is not inhibited by L-histidinol. As a result, histidine ammonia lyases similar to the one isolated from Corynebacteriaceae are uniquely suitable for combination therapy with L-histidinol to treat histidine- and/or histamine-dependent pathologies, for example, infectious viruses, such as human Respiratory Syncytial Virus (RSV), Herpes Simplex Virus (HSV), and Human Immunodeficiency Virus (HIV), as well as cancers.
    Type: Application
    Filed: April 13, 2001
    Publication date: May 2, 2002
    Inventors: Joseph Roberts, Natarajan Sethuraman, Thomas MacAllister
  • Genetically engineered glutaminase and its use in antiviral and anticancer therapy
    Patent number: 6312939
    Abstract: DNA encoding a therapeutically suitable glutaminase has been molecularly cloned. This allows one to obtain a polypeptide which is a therapeutically suitable glutaminase free of contaminating endotoxin. It has been found that this polypeptide is a potent anti-viral agent and when coupled to an anti-tumor monoclonal antibody is a potent anti-cancer agent. The glutaminase of the present invention is particularly useful for treating lung, breast and colon cancer cells and in the treatment of HIV-infected cells.
    Type: Grant
    Filed: April 25, 1995
    Date of Patent: November 6, 2001
    Assignee: ME Medical Enzymes AG
    Inventors: Joseph Roberts, Thomas W MacAllister, Natarajan Sethuraman, Abbie G. Freeman