Abstract: The present invention comprises a novel kit with a wearable unit along with associated intelligent entities and non-intrusive tremor relieving interventions. The interventions include an automatically controllable TENS intervention unit with associated cables and electrodes and a buzzer. The wearable unit along with associated intelligent entities detects involuntary movement signals (tremors) in the limbs by measuring the acceleration in multiple dimensions, and ingeniously analyzes the accelerations to identify and isolate occurrences of tremors. This information is analyzed and monitored over time to provide significant insight about the tremors such as the dominant frequency (or frequencies), percent time with tremor, median tremor duration, and intensity. The TENS unit provides electrical stimulation which can dampen the intensity of involuntary movement and/or temporarily suspend tremor activity. This (TENS) unit can be manually or automatically controlled.

Abstract: Described herein are compositions for delivering a therapeutic agent across the oral mucosa. In general, the compositions comprise at least one therapeutic agent, a carrier, and a buffer system. The therapeutic agents may be acidic, basic, or amphoteric and are initially, at least in part, present in an ionized form. The buffer system comprises at least two different buffering agents and is capable of changing the pH of the saliva from an arbitrary initial pH to a predetermined final pH, independent of the arbitrary initial pH, and of sustaining the final pH for a predetermined period of time. In addition, the buffer systems described herein favor the substantially complete conversion of the ionized form of the therapeutic agent to the un-ionized form so that practically all of the therapeutic agent will be delivered rapidly across the mucous membranes of the oral cavity. Chewing gums, lozenges, and quick-dissolving tablets are exemplified.