Patents by Inventor Nathalia Giese

Nathalia Giese has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Parovirus having a CpG-enriched genome useful for cancer therapy
    Patent number: 10098917
    Abstract: A parvovirus characterized by a CpG-enriched genome, wherein the genome contains at least 2 additional CpG inserts that are not present in the wild type genome is described as well as the use of said parvovirus, e.g., a parvovirus based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species for the preparation of a pharmaceutical composition, e.g., for the treatment of cancer, preferably pancreas carcinoma, hepatoma or lymphoma.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: October 16, 2018
    Assignees: Deutsches Krebsforschungszentrum Stiftung des oeffentlichen Rechts, Ruprecht-Karls-Universiaet Heidelberg
    Inventors: Zahari Raykov, Jean Rommelaere, Nathalia Giese, Marc Aprahamian
  • Co-administration of a parvovirus and a cytokine for therapy of pancreatic cancer
    Patent number: 10058591
    Abstract: The present invention relates to a combination of a parvovirus and a cytokine, preferably IFNy, for use in treating pancreatic cancer, in particular a terminal stage of this disease.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: August 28, 2018
    Assignees: Deutsches Krebsforschungszentrum, Ruprecht-Karls-Universitaet Heidelberg
    Inventors: Zahari Raykov, Svitlana Grekova, Laurent Daeffler, Jean Rommelaere, Marc Aprahamian, Nathalia Giese
  • Methods of treating cancer using chemovirotherapy
    Patent number: 9664684
    Abstract: Described is a diagnostic method for predicting the response of a patient to chemovirotherapy or radiovirotherapy, comprising exposing primary tumor cells from a patient, e.g., tumor cells obtained from a brain tumor or pancreatic cancer, to (i) a parvovirus and/or (ii) a chemotherapeutic agent or radiotherapy, and determining the reduction of the expression or concentration of ISG15.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: May 30, 2017
    Assignees: Deutsches Krebsforschungszentrum, Ruprecht-Karls-Universitaet Heidelberg, Universitaetsklinikum Heidelberg
    Inventors: Nathalia Giese, Jens Werner, Markus Buechler, Thomas Giese, Laurent Daeffler, Celina Czeipluch, Jean Rommelaere, Zahari Raykov
  • Co-Administration of a Parvovirus and a Cytokine for Therapy of Pancreatic Cancer
    Publication number: 20160082085
    Abstract: The present invention relates to a combination of a parvovirus and a cytokine, preferably IFNy, for use in treating pancreatic cancer, in particular a terminal stage of this disease.
    Type: Application
    Filed: December 3, 2015
    Publication date: March 24, 2016
    Inventors: Zahari RAYKOV, Svitlana GREKOVA, Laurent DAEFFLER, Jean ROMMELAERE, Marc APRAHAMIAN, Nathalia GIESE
  • Co-Administration of a Parvovirus and a Cytokine for Therapy of Pancreatic Cancer
    Publication number: 20140328798
    Abstract: The present invention relates to a combination of a parvovirus and a cytokine, preferably IFN?, for use in treating pancreatic cancer, in particular a terminal stage of this disease.
    Type: Application
    Filed: November 14, 2012
    Publication date: November 6, 2014
    Inventors: Zahari Raykov, Svitlana Grekova, Laurent Daeffler, Jean Rommelaere, Marc Aprahamian, Nathalia Giese
  • Parvovirus having a CPG-enriched genome useful for cancer therapy
    Patent number: 8535929
    Abstract: A parvovirus characterized by a CpG-enriched genome, wherein the genome contains at least 2 additional CpG inserts that are not present in the wild type genome is described as well as the use of said parvovirus, e.g., a parvovirus based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species for the preparation of a pharmaceutical composition, e.g., for the treatment of cancer, preferably pancreas carcinoma, hepatoma or lymphoma.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: September 17, 2013
    Assignees: Deutsches Krebsforschungszentrum, Ruprecht-Karls-Universitaet Heidelberg
    Inventors: Zahari Raykov, Jean Rommelaere, Nathalia Giese, Marc Aprahamian
  • CO-ADMINISTRATION OF A PARVOVIRUS AND A CYTOKINE FOR THERAPY OF PANCREATIC CANCER
    Publication number: 20130129678
    Abstract: The application relates to a combination of a parvovirus and a cytokine, preferably IFN?, for use in treating pancreatic cancer (PDAC), in particular a terminal stage of this disease.
    Type: Application
    Filed: November 17, 2011
    Publication date: May 23, 2013
    Inventors: Zahari RAYKOV, Svitlana Grekova, Laurent Daeffler, Jean Rommelaere, Marc Aprahamian, Nathalia Giese
  • Diagnostic Method for Predicting the Response of a Patient to Chemovirotherapy or Radiovirotherapy
    Publication number: 20130101989
    Abstract: Described is a diagnostic method for predicting the response of a patient to chemovirotherapy or radiovirotherapy, comprising exposing primary tumor cells from a patient, e.g., tumor cells obtained from a brain tumor or pancreatic cancer, to (i) a parvovirus and/or (ii) a chemotherapeutic agent or radiotherapy, and determining the reduction of the expression or concentration of ISG15.
    Type: Application
    Filed: April 29, 2011
    Publication date: April 25, 2013
    Applicants: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFUNG DES OEFFE, UNIVERSITAETSKLINIKUM HEIDELBERG, RUPRECHT-KARIS-UNIVERSITAET HEIDELBERG
    Inventors: Nathalia Giese, Jens Werner, Markus Buechler, Thomas Giese, Laurent Daeffler, Celina Cziepluch, Jean Rommelaere, Zahari Raykov
  • Parvovirus Having a CPG-Enriched Genome Useful for Cancer Therapy
    Publication number: 20110033425
    Abstract: A parvovirus characterized by a CpG-enriched genome, wherein the genome contains at least 2 additional CpG inserts that are not present in the wild type genome is described as well as the use of said parvovirus, e.g., a parvovirus based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species for the preparation of a pharmaceutical composition, e.g., for the treatment of cancer, preferably pancreas carcinoma, hepatoma or lymphoma.
    Type: Application
    Filed: December 19, 2008
    Publication date: February 10, 2011
    Applicant: Deutsches Krebsforschungszentrum
    Inventors: Zahari Raykov, Jean Rommelaere, Nathalia Giese, Marc Aprahamian