Patents by Inventor Nathalie Adje

Nathalie Adje has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydroxyphenol derivatives, processes for the preparation thereof, pharmaceutical compositions them, and therapeutic uses thereof
    Patent number: 8653134
    Abstract: Compounds of the formula (I): in which A, R1, R2, X, Y and Z are defined in the description, the processes for the preparation of these compounds, the uses thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, and the pharmaceutical compositions comprising them.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: February 18, 2014
    Assignee: Merck Patent GmbH
    Inventors: Catherine Vidal, Nathalie Adje, Stéphane Yvon, Jean Jacques Zeiller
  • Phenylbenzoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic uses thereof
    Patent number: 7863328
    Abstract: Compounds of the formula (1) in which R1, R2, X, Y and Z are as defined in the description, the processes for the preparation of these compounds, the uses thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, and the pharmaceutical compositions comprising them.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: January 4, 2011
    Assignee: Merck Patent GmbH
    Inventors: Michel Brunet, Nathalie Adje, Valérie Guyard-Dangremont, Francis Contard
  • 1-indole-3-carboxylic acid derivatives and their use as PPAR agonists
    Patent number: 7754740
    Abstract: Compounds of the formula (1): in which A, R1, R2 and R3 are as defined in the description, the processes for the preparation of these compounds, the uses thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, and the pharmaceutical compositions comprising them.
    Type: Grant
    Filed: December 17, 2005
    Date of Patent: July 13, 2010
    Assignee: Merck Patent GmbH
    Inventors: Nathalie Adje, Didier Roche, Stéphane Yvon
  • Carboxylic acids and derivatives for the treatment of and preventing diabetes and dyslipidaemia
    Patent number: 7482484
    Abstract: Disclosed are Compounds of formula I And methods of use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: January 27, 2009
    Assignee: Merck Patent GmbH
    Inventors: Nathalie Adje, Michel Brunet, Didier Roche, Jean-Jacques Zeiller, Stéphane Yvon, Valérie Guyard-Dangremont, Francis Contard, Daniel Guerrier, Gérard Ferrand, Yves Bonhomme
  • 6-Phenylhex-5-Enoic Acid Derivatives, Process for the Preparation Thereof, Pharmaceutical Compositions Comprising Them, and Therapeutic Uses Thereof
    Publication number: 20080194608
    Abstract: Compounds of the formula (I): in which R1, R2, R3, R?3 and R4 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, the pharmaceutical compositions comprising them, and the processes for the preparation of these compounds.
    Type: Application
    Filed: December 22, 2005
    Publication date: August 14, 2008
    Inventors: Michel Brunet, Herve Dumas, Catherine Vidal, Nathalie Adje, Benoit Van Hille, Francis Contard
  • Hydroxyphenol Derivatives, Processes For The Preparation Thereof, Pharmaceutical Compositions Them, And Therapeutic Uses Thereof
    Publication number: 20080161308
    Abstract: Compounds of the formula (I): in which A, R1, R2, X, Y and Z are defined in the description, the processes for the preparation of these compounds, the uses thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, and the pharmaceutical compositions comprising them.
    Type: Application
    Filed: December 22, 2005
    Publication date: July 3, 2008
    Inventors: Catherine Vidal, Nathalie Adje, Stephane Yvon, Jean Jacques Zeiller
  • Phenylbenzoic Acid Derivatives, Processes for the Preparation Thereof, Pharmaceutical Compositions Comprising Them, and Therapeutic Uses Thereof
    Publication number: 20080139599
    Abstract: Compounds of the formula (1) in which R1, R2,X, Y and Z are as defined in the description, the processes for the preparation of these compounds, the uses thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, and the pharmaceutical compositions comprising them.
    Type: Application
    Filed: December 22, 2005
    Publication date: June 12, 2008
    Inventors: Michel Brunet, Nathalie Adje, Valerie Guyard-Dangremont, Francis Contard
  • 1H-Indole-3-Carboxylic Acid Derivatives And Their Use As Ppar Agonists
    Publication number: 20080114034
    Abstract: Compounds of the formula (1): in which A, R1, R2 and R3 are as defined in the description, the processes for the preparation of these compounds, the uses thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, and the pharmaceutical compositions comprising them.
    Type: Application
    Filed: December 17, 2005
    Publication date: May 15, 2008
    Inventors: Nathalie Adje, Didier Roche, Stephane Yvon
  • Novel carboxylic acids and derivatives for the treatment of and preventing diabetes and dyslipidaemia
    Publication number: 20060111445
    Abstract: The present invention relates to a compound of the formula ((I): in which: n is an integer chosen from 1, 2 and 3; Y represents O; N—OR9, in which R9 represents H or a saturated hydrocarbon-based aliphatic group; CR10R11, in which R10 and R11, which may be identical or different, represent H or a saturated hydrocarbon-based aliphatic group; R1 and R2, which may be identical or different, represent H or a saturated aliphatic hydrocarbon-based chain; or alternatively R1 and R2 together form an optionally substituted saturated aliphatic hydrocarbon-based chain; the radicals R3 and R4, which may be identical or different, take any of the is meanings given above for R1 and R2, or alternatively R1 and the group R4 borne by the carbon alpha to CR1R2 represent nothing and a double bond links the CR1R2 carbon to the alpha CR3R4 carbon; or alternatively one of the radicals R1 and R2 forms with one of the radicals R3 and R4 an optionally substituted saturated or unsaturated aliphatic hydrocarbon-based chain; one of the
    Type: Application
    Filed: December 16, 2003
    Publication date: May 25, 2006
    Inventors: Nathalie Adje, Michel Brunet, Didier Roche, Jean-Jacques Zeiller, Stephane Yvon, Valerie Guyard-Dangremont, Francis Contard, Daniel Guerrier, Gerard Ferrand
  • 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors and pharmaceutical compositions containing them
    Patent number: 6737433
    Abstract: Imidazole derivatives of the formula: in which R1 and R2 are each independently hydrogen, (C1-C6)alkyl or (C3-C8)cycloalkyl; n is 0, 1 or 2; R3, R4, R5 and R6 are each independently hydrogen or a (C1-C6)alkyl, halogen, cyano, (C1-C6)alkoxy, trifluoromethyl, (C1-C6)alkylthio, (C1-C6)alkylsulfonyl, sulfonamido, acyl, (C1-C6)alkoxycarbonyl, or carboxamido group; R3 and R6 together with the phenyl ring bearing them can also form a benzofurane, or a N-methylbenzotriazole. The invention also relates to pharmaceutical compositions containing these derivatives, and to the uses thereof.
    Type: Grant
    Filed: December 16, 2002
    Date of Patent: May 18, 2004
    Assignee: Laboratoire Theramex
    Inventors: Nathalie Adje, Paule Bonnet, Denis Carniato, Remi Delansorne, Jean Lafay, Jean-Claude Pascal