Patents by Inventor Nathalie BALCH

Nathalie BALCH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of retinyl esters
    Patent number: 11905542
    Abstract: The present invention is related to a novel enzymatic process for production of retinyl esters, such as in particular retinyl long chain esters, via conversion of retinol, which process includes the use of enzymes having acyltransferase activity. Said process might be used for biotechnological production of vitamin A.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: February 20, 2024
    Assignee: DSM IP ASSETS B.V.
    Inventors: Nathalie Balch, Paul Blomquist, Reed Doten, Peter Houston, Ethan Lam, Jenna McMahon, Joshua Trueheart, Celine Viarouge
  • BIOSYNTHESIS OF RETINOIDS
    Publication number: 20230227862
    Abstract: The present invention is related to a novel enzymatic process for production of retinoids via a multi-step process, which process includes the use of heterologous enzymes having activity in a carotene-producing host cell, particularly wherein such process results in high percentage of retinoids, in trans-isoform.
    Type: Application
    Filed: January 30, 2023
    Publication date: July 20, 2023
    Inventors: Nathalie BALCH, Paul BLOMQUIST, Reed DOTEN, Peter HOUSTON, Ethan LAM, Jenna MCMAHON, Joshua TRUEHEART, Celine VIAROUGE
  • Biosynthesis of retinoids
    Patent number: 11578344
    Abstract: The present invention is related to a novel enzymatic process for production of retinoids via a multi-step process, which process includes the use of heterologous enzymes having activity in a carotene-producing host cell, particularly wherein such process results in high percentage of retinoids, in trans-isoform.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: February 14, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Nathalie Balch, Paul Blomquist, Reed Doten, Peter Houston, Ethan Lam, Jenna McMahon, Joshua Trueheart, Celine Viarouge
  • Acetyl transferases and their use for producing carotenoids
    Patent number: 10865392
    Abstract: The present invention relates to acetyl transferases, nucleic acid sequences coding therefore, expression constructs and vectors comprising these sequences, microorganisms transformed therewith and use thereof.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: December 15, 2020
    Assignee: DSM IP ASSETS B.V.
    Inventors: Christopher Farrell, Peter Houston, Lisa Laprade, Nathalie Balch, Maria Mayorga
  • PRODUCTION OF TRANS-RETINAL
    Publication number: 20200277644
    Abstract: The present invention is related to a novel enzymatic process for production of vitamin A aldehyde (retinal) via stereoselective conversion of beta-carotene which process includes the use of trans-selective enzymes having activity as beta-carotene oxidases (BCOs), in particular having preference for trans-retinal. 5 Said process is in particular useful for biotechnological production of vitamin A.
    Type: Application
    Filed: September 25, 2018
    Publication date: September 3, 2020
    Inventors: Nathalie BALCH, Paul BLOMQUIST, Reed DOTEN, Peter HOUSTON, Ethan LAM, Jenna MCMAHON, Joshua TRUEHEART, Celine VIAROUGE, René Marcel DE JONG
  • PRODUCTION OF RETINOL
    Publication number: 20200248151
    Abstract: The present invention is related to a novel enzymatic process for production of vitamin A alcohol (retinol) via conversion of retinal, which process includes the use of heterologous enzymes having activity as retinal reductase, particularly wherein the reaction leads to at least about 90% conversion of retinal into retinol. Said process is particularly useful for biotechnological production of vitamin A.
    Type: Application
    Filed: September 25, 2018
    Publication date: August 6, 2020
    Inventors: Nathalie BALCH, Paul BLOMQUIST, Reed DOTEN, Peter HOUSTON, Ethan LAM, Jenna MCMAHON, Joshua TRUEHEART, Celine VIAROUGE
  • PRODUCTION OF RETINYL ESTERS
    Publication number: 20200239924
    Abstract: The present invention is related to a novel enzymatic process for production of retinyl esters, such as in particular retinyl long chain esters, via conversion of retinol, which process includes the use of enzymes having acyltransferase activity. Said process might be used for biotechnological production of vitamin A.
    Type: Application
    Filed: September 25, 2018
    Publication date: July 30, 2020
    Inventors: Nathalie BALCH, Paul BLOMQUIST, Reed DOTEN, Peter HOUSTON, Ethan LAM, Jenna MCMAHON, Joshua TRUEHEART, Celine VIAROUGE
  • PRODUCTION OF RETINYL ESTERS
    Publication number: 20200239925
    Abstract: The present invention is related to production of retinyl esters, such as in particular retinyl acetate, an important building block for production of vitamin A. The retinyl esters might be generated via enzymatic conversion of retinol which process includes the use of enzymes with acetyl-transferase (ATF) activity, thus acetylating retinol into retinol/retinyl acetate. Said process is particularly useful for biotechnological production of vitamin A.
    Type: Application
    Filed: September 25, 2018
    Publication date: July 30, 2020
    Inventors: Nathalie BALCH, Paul BLOMQUIST, Reed DOTEN, Peter HOUSTON, Ethan LAM, Jenna MCMAHON, Joshua TRUEHEART, Celine VIAROUGE, René Marcel DE JONG
  • BIOSYNTHESIS OF RETINOIDS
    Publication number: 20200231993
    Abstract: The present invention is related to a novel enzymatic process for production of retinoids via a multi-step process, which process includes the use of heterologous enzymes having activity in a carotene-producing host cell, particularly wherein such process results in high percentage of retinoids, in trans-isoform.
    Type: Application
    Filed: September 25, 2018
    Publication date: July 23, 2020
    Inventors: Nathalie BALCH, Paul BLOMQUIST, Reed DOTEN, Peter HOUSTON, Ethan LAM, Jenna MCMAHON, Joshua TRUEHEART, Celine VIAROUGE
  • ACETYL TRANSFERASES AND THEIR USE FOR PRODUCING CAROTENOIDS
    Publication number: 20200123507
    Abstract: The present invention relates to acetyl transferases, nucleic acid sequences coding therefore, expression constructs and vectors comprising these sequences, microorganisms transformed therewith and use thereof.
    Type: Application
    Filed: October 4, 2019
    Publication date: April 23, 2020
    Inventors: Christopher FARRELL, Peter HOUSTON, Lisa LAPRADE, Nathalie BALCH, Maria MAYORGA
  • Acetyl transferases and their use for producing carotenoids
    Patent number: 10465174
    Abstract: The present invention relates to novel acetyl transferases, nucleic acid sequences coding therefore, expression constructs and vectors comprising these sequences, microorganisms transformed therewith and use thereof.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: November 5, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Christopher Farrell, Peter Houston, Lisa Laprade, Nathalie Balch, Maria Mayorga
  • ACETYL TRANSFERASES AND THEIR USE FOR PRODUCING CAROTENOIDS
    Publication number: 20150322412
    Abstract: The present invention relates to novel acetyl transferases, nucleic acid sequences coding therefore, expression constructs and vectors comprising these sequences, microorganisms transformed therewith and use thereof.
    Type: Application
    Filed: August 28, 2013
    Publication date: November 12, 2015
    Inventors: Christopher FARRELL, Peter HOUSTON, Lisa LAPRADE, Nathalie BALCH, Maria MAYORGA