Patents by Inventor Nathalie Claudie Isabelle Amblard

Nathalie Claudie Isabelle Amblard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRICYCLIC PYRIMIDINES AS CYCLIN-DEPENDENT KINASE 7 (CDK7) INHIBITORS
    Publication number: 20240109912
    Abstract: The invention relates to pharmaceutical compounds of formula (I) and pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds as inhibitors of cyclin-dependent kinase 7 (CDK7) and to their use in the treatment of diseases, e.g., cancer.
    Type: Application
    Filed: December 17, 2021
    Publication date: April 4, 2024
    Inventors: Ian STANSFIELD, Yannick Aimé Eddy LIGNY, Yvan René Ferdinand SIMONNET, Nathalie Claudie Isabelle AMBLARD
  • N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives as perk inhibitors
    Patent number: 9688662
    Abstract: The present invention relates to N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives of Formula (I) wherein R1, R2, R3, R4, R5, R6 and A have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors of PERK. The invention further relates to processes for preparing such compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: June 27, 2017
    Assignee: Janssen Pharmaceutica NV
    Inventors: Ian Stansfield, Yannick Aime Eddy Ligny, Nathalie Claudie Isabelle Amblard, Matthias Luc Aime Versele
  • NOVEL N-(2,3-DIHYDRO-1H-PYRROLO[2,3-b]PYRIDIN-5-YL)-4-QUINAZOLINAMINE AND N-(2,3-DIHYDRO-1H-INDOL-5-YL)-4-QUINAZOLINAMINE DERIVATIVES AS PERK INHIBITORS
    Publication number: 20160039798
    Abstract: The present invention relates to N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives of Formula (I) wherein R1, R2, R3, R4, R5, R6 and A have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors of PERK. The invention further relates to processes for preparing such compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
    Type: Application
    Filed: March 31, 2014
    Publication date: February 11, 2016
    Applicant: JANSSEN PHARMACEUTICA NV
    Inventors: Ian Stansfield, Yannick Aime Eddy Ligny, Nathalie Claudie Isabelle Amblard, Matthias Luc Aime Versele
  • Indole derivatives as anticancer agents
    Patent number: 8541442
    Abstract: The present invention provides compounds of formula (I), their use for the treatment of cancer as well as pharmaceutical compositions comprising said compounds of formula (I).
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: September 24, 2013
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Bruno Schoentjes, Sophie Descamps, Nathalie Claudie Isabelle Amblard
  • INDOLE DERIVATIVES AS ANTICANCER AGENTS
    Publication number: 20110294846
    Abstract: The present invention provides compounds of formula (I), their use for the treatment of cancer as well as pharmaceutical compositions comprising said compounds of formula (I).
    Type: Application
    Filed: February 3, 2010
    Publication date: December 1, 2011
    Inventors: Bruno Schoentjes, Sophie Descamps, Nathalie Claudie Isabelle Amblard