Patents by Inventor Nathalie Desmaris

Nathalie Desmaris has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vector for expressing alpha-N-acetyl-galactosaminidase and method of treating MPS I by stereotactic injection into the brain of a mammal
    Publication number: 20060182717
    Abstract: A purified nucleic acid molecule which is capable of expressing a lysosomal enzyme wherein said nucleic acid molecule comprises at least a sequence coding for said lysosomal enzyme and a promoter highly active in the brain inserted upstream from said sequence.
    Type: Application
    Filed: January 11, 2006
    Publication date: August 17, 2006
    Applicant: Institut Pasteur
    Inventors: Nathalie Desmaris, Jean Heard
  • Vector for expressing ?-L-iduronidase and method of treating MPS I by stereotactic injection into the brain of a mammal
    Patent number: 7090836
    Abstract: A purified nucleic acid molecule capable of expressing a lysosomal enzyme, e.g., iduronidase or arylsulphatase, is provided. The molecule includes a promoter of the phosphoglycerate kinase gene to facilitate expression of the lysosomal enzyme in the brain. Expressing the lysosomal enzyme in the brain of patients with lysosomal storage diseases, such as mucopolysaccharidosis, provides treatment for the neurological aspects of these diseases. The invention also provides a method of gene therapy for lysosomal storage diseases by administering the nucleic acid molecule in the form of a vector.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: August 15, 2006
    Assignee: Institut Pasteur
    Inventors: Nathalie Desmaris, Jean Michel Heard
  • Purified nucleic acid molecule for the expression of a lysosomal enzyme and use thereof for preventing or treating lysosomal storage diseases
    Publication number: 20040023218
    Abstract: A purified nucleic acid molecule which is capable of expressing a lysosomal enzyme wherein said nucleic acid molecule comprises at least a sequence coding for said lysosomal enzyme and a promoter highly active in the brain inserted upstream from said sequence.
    Type: Application
    Filed: June 21, 2002
    Publication date: February 5, 2004
    Inventors: Nathalie Desmaris, Jean Michel Heard