Patents by Inventor Nathalie Dubois

Nathalie Dubois has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240077522
    Abstract: A voltage matching circuit receives a first voltage received by a connector, and outputs a second voltage. The second voltage is equal to the first voltage, if the first voltage is less than a threshold voltage. The second voltage is equal to the first voltage divided by a first factor, if the first voltage is greater than or equal to the threshold voltage.
    Type: Application
    Filed: July 20, 2023
    Publication date: March 7, 2024
    Inventors: Christophe Lorin, Nathalie Dubois
  • Publication number: 20120231527
    Abstract: The present application generally relates to a process for the reduction of gas emissions, treatment of effluents and production of algal biomass, and to a system for the reduction of gas emissions, treatment of effluents and production of algal biomass.
    Type: Application
    Filed: September 10, 2010
    Publication date: September 13, 2012
    Applicant: Alga-Labs Inc.
    Inventors: Nathalie Dubois-Calero, Gerard Magnin
  • Publication number: 20100240100
    Abstract: The invention is composed of monoclonal human MN antibodies or MN antibody fragments that target the GEEDLP repeat within the proteoglycan domain. The proteoglycan domain of the MN cell surface protein contains four of these identical GEEDLP repeats. Binding to the desired epitope is verified by competition ELISA, where ELISA signal can be attenuated by co-incubation with a peptide containing this repeat (PGEEDLPGEEDLP). This inhibition of binding can also be verified using Biacore assays, where binding of desired antibodies to immobilized MN or proteoglycan peptides can be inhibited by the peptide repeat. In addition to binding to the peptide repeat, human anti-MN antibodies can inhibit the cell adhesion of CGL-1 cells to MN coated plastic plates. Human anti-MN antibodies have been used to diagnose and quantify MN expression in cancer cells and tumors using FACS and immunohistochemical methods.
    Type: Application
    Filed: December 8, 2008
    Publication date: September 23, 2010
    Inventors: Toshihiko Takeuchi, Nathalie Dubois-Stringfellow, John E. Murphy, Julie Rinkenberger
  • Patent number: 7462696
    Abstract: The invention is composed of monoclonal human MN antibodies or MN antibody fragments that target the GEEDLP (SEQ ID NO: 118) repeat within the proteoglycan domain. The proteoglycan domain of the MN cell surface protein contains four of these identical GEEDLP (SEQ ID NO: 118) repeats. Binding to the desired epitope is verified by competition ELISA, where ELISA signal can be attenuated by co-incubation with a peptide containing this repeat (PGEEDLPGEEDLP (SEQ ID NO: 119)). This inhibition of binding can also be verified using Biacore assays, where binding of desired antibodies to immobilized MN or proteoglycan peptides can be inhibited by the peptide repeat. In addition to binding to the peptide repeat, human anti-MN antibodies can inhibit the cell adhesion of CGL-1 cells to MN coated plastic plates. Human anti-MN antibodies have been used to diagnose and quantify MN expression in cancer cells and tumors using FACS and immunohistochemical methods.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: December 9, 2008
    Assignee: Bayer Pharmaceutical Corporation
    Inventors: Toshihiko Takeuchi, Nathalie Dubois-Stringfellow, John E. Murphy, Julie Rinkenberger
  • Patent number: 7462592
    Abstract: This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: December 9, 2008
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Ronald N. Zuckermann, Nathalie Dubois-Stringfellow, Varavani Dwarki, Michael A. Innis, John E. Murphy, Fred E. Cohen, Tetsuo Uno
  • Publication number: 20080089938
    Abstract: This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.
    Type: Application
    Filed: October 22, 2002
    Publication date: April 17, 2008
    Inventors: Ronald Zuckermann, Nathalie Dubois-Stringfellow, Varavani Dwarki, Michael Innis, John Murphy, Fred Cohen, Tetsuo Uno
  • Publication number: 20050090395
    Abstract: The present invention relates to the biological control of weedy deciduous trees. More particularly, the invention relates to novel purified cultures of Chondrostereum purpureum fungus, their use in compositions and methods for biologically controlling deciduous weed trees in forestry management.
    Type: Application
    Filed: June 27, 2002
    Publication date: April 28, 2005
    Inventors: Lyne Gosselin, Nathalie Dubois-Calero, Norbert Major
  • Patent number: 6844000
    Abstract: A purified Parapoxvirus ovis envelope protein termed “B2L” can be used as a monotherapeutic agent. B2L protein also can be used in screening methods to identify potential therapeutic agents for modulating a subject's immune response to the B2L protein.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: January 18, 2005
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Delanie Cassell, Jeffrey S. Tepper, Isa Samuels, Nathalie Dubois-Stringfellow
  • Patent number: 6835381
    Abstract: The present invention provides methods for modulating angiogenesis by administering anti-angiogenic Ang-7 polypeptides to a subject. Methods of modulating angiogenesis by administering an anti-angiogenic ANG-7 nucleic acid are also provided.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: December 28, 2004
    Assignee: Bayer AG
    Inventors: Gabi Friedrich, Gustav Hagen, Maresa Wick, Dmitry Zubov, Nathalie Dubois-Stringfellow
  • Publication number: 20040023864
    Abstract: Ryk protein was found to have a novel activity in regulating angiogenesis. New variant Ryk proteins were constructed that were useful in modulating the capillary forming activity of endothelial cells. Variant Ryk proteins, may be employed as therpeutics in diseases such as cancer, wound healing, diabetic retinopathies, macular degeneration, and cardiovascular diseases, and other diseases or clinical conditions where angiogenesis is relevant to the causation or treatment of the disease.
    Type: Application
    Filed: June 17, 2003
    Publication date: February 5, 2004
    Inventors: Steve Roczniak, Nathalie A. Dubois-Stringfellow, Alya Zolotorev
  • Publication number: 20030185890
    Abstract: This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.
    Type: Application
    Filed: October 22, 2002
    Publication date: October 2, 2003
    Inventors: Ronald N. Zuckermann, Nathalie Dubois-Stringfellow, Varavani Dwarki, Michael A. Innis, John E. Murphy, Fred E. Cohen, Tetsuo Uno
  • Publication number: 20030109483
    Abstract: A purified Parapoxvirus ovis envelope protein termed “B2L” can be used as a monotherapeutic agent. B2L protein also can be used in screening methods to identify potential therapeutic agents for modulating a subject's immune response to the B2L protein.
    Type: Application
    Filed: December 6, 2002
    Publication date: June 12, 2003
    Inventors: Delanie Cassell, Jeffrey S. Tepper, Isa Samuels, Nathalie Dubois-Stringfellow
  • Publication number: 20030077277
    Abstract: The invention is composed of monoclonal human MN antibodies or MN antibody fragments that target the GEEDLP repeat within the proteoglycan domain. The proteoglycan domain of the MN cell surface protein contains four of these identical GEEDLP repeats. Binding to the desired epitope is verified by competition ELISA, where ELISA signal can be attenuated by co-incubation with a peptide containing this repeat (PGEEDLPGEEDLP). This inhibition of binding can also be verified using Biacore assays, where binding of desired antibodies to immobilized MN or proteoglycan peptides can be inhibited by the peptide repeat. In addition to binding to the peptide repeat, human anti-MN antibodies can inhibit the cell adhesion of CGL-1 cells to MN coated plastic plates. Human anti-MN antibodies have been used to diagnose and quantify MN expression in cancer cells and tumors using FACS and immunohistochemical methods.
    Type: Application
    Filed: October 18, 2002
    Publication date: April 24, 2003
    Inventors: Toshihiko Takeuchi, Nathalie Dubois-Stringfellow, John E. Murphy, Julie Rinkenberger
  • Patent number: 6468986
    Abstract: This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: October 22, 2002
    Assignee: Chiron Corporation
    Inventors: Ronald N. Zuckermann, Nathalie Dubois-Stringfellow, Varavani Dwarki, Michael A. Innis, John E. Murphy, Fred E. Cohen, Tetsuo Uno
  • Patent number: 6251433
    Abstract: This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.
    Type: Grant
    Filed: August 13, 1997
    Date of Patent: June 26, 2001
    Assignee: Chiron Corporation
    Inventors: Ronald N. Zuckermann, Nathalie Dubois-Stringfellow, Varavani Dwarki, Michael A. Innis, John E. Murphy, Fred E. Cohen, Tetsuo Uno
  • Patent number: 6198321
    Abstract: A device for the generation of a drive signal phase-shifted with respect to an external synchronization signal includes a first digital phase-locked loop to give a reference signal, servo-linked to the external synchronization signal by a current phase among N phases of a high frequency signal. The device includes a second digital phase-locked loop including a measuring circuit to measure the position of an active edge of the drive signal or a derived signal that is delayed with respect to an active edge of the reference signal. The second phase-locked loop also includes a circuit to compute the phase shift to be made and a phase-shift circuit. The measurement circuit includes a circuit for the rough measurement of the position, controlled by a fixed phase of the high frequency signal independent of the present phase of locking in the first loop. The digital computation circuit accounts for this shift between the fixed phase and the present phase.
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: March 6, 2001
    Assignee: STMicroelectronics S.A.
    Inventors: Nicolas Lebouleux, Benoît Marchand, Corrine Ianigro, Nathalie Dubois
  • Patent number: 5870044
    Abstract: An digital-analog converter uses at least 2.sup.N -1 identical current sources capable of being calibrated to convert a number encoded on N bits and an additional current source designed to replace one of the 2.sup.N -1 current sources during the calibration of one of said sources. The additional current source is connected to the output by means of a sole additional commutator.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: February 9, 1999
    Assignee: SGS-Thomson Microelectronics S.A.
    Inventors: Francis Dell'ova, Nathalie Dubois, Olivier Scouarnec