Patents by Inventor Nathalie Methot

Nathalie Methot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Irreversible caspase-3 inhibitors as active site probes
    Publication number: 20060069038
    Abstract: The present invention encompasses a compound of Formula (I) useful as caspase active site probes. These probes can be used to determine whether a caspase has been activated, in cells or in tissues of animal models of various pathologies. Furthermore, through competition based assays, these caspase active site probes can be used to calculate the percentage of occupancy of active caspases by other, unlabeled inhibitors.
    Type: Application
    Filed: February 5, 2004
    Publication date: March 30, 2006
    Inventors: John Colucci, Andre Giroux, Yongxin Han, Nathalie Methot, Donald Nicholson, Sophie Roy, John Vaillancourt, Paul Tawa
  • Human Prt1-like subunit protein (hPrt1) and human eIF4G-like protein (p97) genes
    Publication number: 20030022345
    Abstract: The present invention relates to novel human Prt1 (hPrt1) and eIF4G-like (p97) proteins which are involved in eukaryotic transcription In particular, isolated nucleic acid molecules are provided encoding the human hPrt1 and p97 proteins. hPrt1 and p97 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of hPrt1 and p97 activity. Also provided are therapeutic methods for treating disease states associated with the hPrt1 and p97 proteins.
    Type: Application
    Filed: July 23, 2002
    Publication date: January 30, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Henrik Steen Olsen, Steven Michael Ruben, Nahum Sonenberg, Hiroaki Imataka, Nathalie Methot, Eran Rom
  • Human Prt1-like subunit protein (hPrt1) and human eIF4G-like protein (p97) genes
    Publication number: 20020052024
    Abstract: The present invention relates to novel human Prt1 (hPrt1) and eIF4G-like (p97) proteins which are involved in eukaryotic transcription In particular, isolated nucleic acid molecules are provided encoding the human hPrt1 and p97 proteins. hprt1 and p97 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of hPrt1 and p97 activity. Also provided are therapeutic methods for treating disease states associated with the hPrt1 and p97 proteins.
    Type: Application
    Filed: September 18, 2001
    Publication date: May 2, 2002
    Applicant: Human Genome Sciences, Inc.
    Inventors: Henrik S. Olsen, Steven M. Ruben, Nahum Sonenberg, Hiroaki Imataka, Nathalie Methot, Eran Rom
  • Human Prt1-like subunit protein (hPrt1) polynucleotides
    Patent number: 6316225
    Abstract: The present invention relates to novel human Prt1 (hPrt1) and eIF4G-like (p97) proteins which are involved in eukaryotic transcription. In particular, isolated nucleic acid molecules are provided encoding the human hPrt1 and p97 proteins. hPrt1 and p97 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of hPrt1 and p97 activity. Also provided are therapeutic methods for treating disease states associated with the hPrt1 and p97 proteins.
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: November 13, 2001
    Assignees: Human Genome Sciences, Inc., McGill University
    Inventors: Henrik Steen Olsen, Steven Michael Ruben, Nahum Sonenberg, Nathalie Methot, Eran Rom
  • Isolated human Prt1 protein
    Patent number: 6093795
    Abstract: The present invention relates to novel human Prt1 (hPrt1) and eIF4G-like (p97) proteins which are involved in eukaryotic transcription. In particular, isolated nucleic acid molecules are provided encoding the human hPrt1 and p97 proteins. hPrt1 and p97 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of hPrt1 and p97 activity. Also provided are therapeutic methods for treating disease states associated with the hPrt1 and p97 proteins.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: July 25, 2000
    Assignees: Human Genome Sciences, Inc., McGill University
    Inventors: Henrik Steen Olsen, Steven Michael Ruben, Nahum Sonenberg, Nathalie Methot, Eran Rom