Patents by Inventor Nathalie Y.R. Agar

Nathalie Y.R. Agar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and methods for single cell culture and analysis by microscopy and MALDI mass spectrometry
    Patent number: 10032615
    Abstract: Systems and methods for single cell culture and analysis by microscopy and matrix assisted laser desorption ionization mass spectrometry are disclosed. The systems and methods isolate a plurality of cells in a plurality of wells such that a predetermined number of the plurality of wells contain one and only one cell. The plurality of wells allow for optical interrogation of the cells and subsequent matrix assisted laser desorption ionizing of molecules within the cells.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: July 24, 2018
    Assignees: The Brigham and Women's Hospital, Massachusetts Institute of Technology
    Inventors: Nathalie Y. R. Agar, J. Christopher Love, Denis Loginov
  • Tissue sample preparation, and MALDI MS imaging thereof
    Patent number: 9625359
    Abstract: Aspects of the present invention relate to a method for the preparation of samples for MALDI MS imaging. Certain embodiments relate to a method of matrix deposition for samples, wherein tissue sections are prepared via a synergistic combination of fixation with matrix. In certain embodiments, tissue is fixed with cold solvent, according to well-established histology protocols, and in the presence of matrix, allowing for high resolution spatial mapping of protein, lipid, sugar, and/or nucleic acid distribution. In certain embodiments, the present invention relates to fixation with matrix of whole organisms. In certain embodiments, animals are perfused with fixation and matrix mixtures, which allows for direct mass spectrometry analysis.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: April 18, 2017
    Assignees: Brandeis University, The Brigham and Women's Hospital, Inc.
    Inventors: Jeffrey N. Agar, Nathalie Y. R. Agar
  • Systems and Methods for Single Cell Culture and Analysis by Microscopy and Maldi Mass Spectrometry
    Publication number: 20150364307
    Abstract: Systems and methods for single cell culture and analysis by microscopy and matrix assisted laser desorption ionization mass spectrometry are disclosed. The systems and methods isolate a plurality of cells in a plurality of wells such that a predetermined number of the plurality of wells contain one and only one cell. The plurality of wells allow for optical interrogation of the cells and subsequent matrix assisted laser desorption ionizing of molecules within the cells.
    Type: Application
    Filed: June 16, 2015
    Publication date: December 17, 2015
    Inventors: Nathalie Y.R. Agar, J. Christopher Love, Denis Loginov
  • Tissue Sample Preparation, and MALDI MS Imaging Thereof
    Publication number: 20150300930
    Abstract: Aspects of the present invention relate to a method for the preparation of samples for MALDI MS imaging. Certain embodiments relate to a method of matrix deposition for samples, wherein tissue sections are prepared via a synergistic combination of fixation with matrix. In certain embodiments, tissue is fixed with cold solvent, according to well-established histology protocols, and in the presence of matrix, allowing for high resolution spatial mapping of protein, lipid, sugar, and/or nucleic acid distribution. In certain embodiments, the present invention relates to fixation with matrix of whole organisms. In certain embodiments, animals are perfused with fixation and matrix mixtures, which allows for direct mass spectrometry analysis.
    Type: Application
    Filed: January 22, 2015
    Publication date: October 22, 2015
    Inventors: Jeffrey N. Agar, Nathalie Y. R. Agar
  • Tissue sample preparation and MALDI MS imaging thereof
    Patent number: 8945941
    Abstract: Aspects of the present invention relate to a method for the preparation of samples for MALDI MS imaging. Certain embodiments relate to a method of matrix deposition for samples, wherein tissue sections are prepared via a synergistic combination of fixation with matrix. In certain embodiments, tissue is fixed with cold solvent, according to well-established histology protocols, and in the presence of matrix, allowing for high resolution spatial mapping of protein, lipid, sugar, and/or nucleic acid distribution. In certain embodiments, the present invention relates to fixation with matrix of whole organisms. In certain embodiments, animals are perfused with fixation and matrix mixtures, which allows for direct mass spectrometry analysis.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: February 3, 2015
    Assignees: Brandeis University, The Brigham and Women's Hospital, Inc.
    Inventors: Jeffrey N. Agar, Nathalie Y. R. Agar
  • Tissue Sample Preparation and MALDI MS Imaging Thereof
    Publication number: 20090325222
    Abstract: Aspects of the present invention relate to a method for the preparation of samples for MALDI MS imaging. Certain embodiments relate to a method of matrix deposition for samples, wherein tissue sections are prepared via a synergistic combination of fixation with matrix. In certain embodiments, tissue is fixed with cold solvent, according to well-established histology protocols, and in the presence of matrix, allowing for high resolution spatial mapping of protein, lipid, sugar, and/or nucleic acid distribution. In certain embodiments, the present invention relates to fixation with matrix of whole organisms. In certain embodiments, animals are perfused with fixation and matrix mixtures, which allows for direct mass spectrometry analysis.
    Type: Application
    Filed: May 24, 2007
    Publication date: December 31, 2009
    Applicants: BRANDEIS UNIVERSITY, THE BRIGHAM AND WOMEN'S HOSPITAL
    Inventors: Jeffrey N. Agar, Nathalie Y.R. Agar, Peter M. Black