Abstract: The invention relates to compounds of formula I wherein R1, R2 and - - - - - are as defined herein, pharmaceutical compositions comprising the compounds and methods of treating COVID-19 in a patient by administering therapeutically effective amounts of the compounds and methods of inhibiting or preventing replication of SARS-CoV-2 with the compounds.

Abstract: Methods and systems for processing signals and data are disclosed. An example method can comprise receiving a first portion of a first signal. An example method can comprise processing the first portion of the first signal based on a module. The module can comprise instructions for physical layer processing. An example method can comprise receiving an update for the module. The update can be configured to modify the instructions for physical layer processing. The module can be reconfigured based on the update. An example method can comprise processing at least one of a second portion of the first signal and a second signal based on the module reconfigured based on the update.

Abstract: Methods and systems for processing signals and data are disclosed. An example method can comprise receiving a first portion of a first signal. An example method can comprise processing the first portion of the first signal based on a module. The module can comprise instructions for physical layer processing. An example method can comprise receiving an update for the module. The update can be configured to modify the instructions for physical layer processing. The module can be reconfigured based on the update. An example method can comprise processing at least one of a second portion of the first signal and a second signal based on the module reconfigured based on the update.

Abstract: Database servers may maintain a database according to a database schema. A database change management system can include a profile service configured to collect database profile information. A forecast service can be configured to use SQL parsing to generate change objects and generate a forecast report indicative of a prediction of a failure or success of an implementation of the set of changes.

Abstract: Methods and apparatus to align applique cutters are disclosed. A disclosed example alignment rail is for use with cutting an applique relative to a surface of a vehicle. The example alignment rail includes a base to contact the surface. The example alignment rail also includes a body including a cross-sectional profile extending along a longitudinal axis of the alignment rail. The example alignment rail also includes a groove of the cross-sectional profile extending along the longitudinal axis, where the groove is to align movement of a cutting tool to cut the applique.

Abstract: Database servers may maintain a database according to a database schema. A database change management system can include a profile service configured to collect database profile information. A forecast service can be configured to use SQL parsing to generate change objects and generate a forecast report indicative of a prediction of a failure or success of an implementation of the set of changes.

Abstract: A device for converting energy of a fluid to electrical energy is disclosed. The device comprises a pressure vessel having an inlet port for a fluid. A pair of charge collecting electrodes is spaced apart from each other along a collection direction and disposed within the pressure vessel. An electric field generator is configured to generate an electric field in the pressure vessel along a field direction to separate charged species in the fluid. Other disclosed devices provide a current flow delay to encourage charge build up or illumination with electromagnetic radiation. Yet other devices are arranged for fluid flow rather than pressure. Also disclosed is a system comprising any one of the disclosed devices and related methods. The disclosure may find application, for example, in providing a source of energy for an electric vehicle.

Abstract: A device for converting kinetic energy of a fluid to electrical energy is disclosed. The device comprises a flow chamber having an inlet port for a fluid and an exhaust port for the fluid. A pair of charge collecting electrodes is spaced apart from each other along a collection direction and disposed within the flow chamber. An electric field generator is configured to generate an electric field in the flow chamber along a field direction to separate charged species in the fluid. A flow path of the fluid between the inlet port and the exhaust port may have a flow direction with a component along the first direction and a component along the second direction. Also disclosed is a system comprising the device and a related method. The disclosure may find application, for example, in providing a source of energy for an electric vehicle.

Abstract: Database servers may maintain a database according to a database schema. A database change management system can include a profile service configured to collect database profile information. A forecast service can be configured to use SQL parsing to generate change objects and generate a forecast report indicative of a prediction of a failure or success of an implementation of the set of changes.

Abstract: A device for converting kinetic energy of a fluid to electrical energy is disclosed. The device comprises a flow chamber having an inlet port for a fluid and an exhaust port for the fluid. A pair of charge collecting electrodes is spaced apart from each other along a collection direction and disposed within the flow chamber. An electric field generator is configured to generate an electric field in the flow chamber along a field direction to separate charged species in the fluid. A flow path of the fluid between the inlet port and the exhaust port may have a flow direction with a component along the first direction and a component along the second direction. Also disclosed is a system comprising the device and a related method. The disclosure may find application, for example, in providing a source of energy for an electric vehicle.

Abstract: This disclosure is directed to systems for stabilizing and protecting musical instruments inside their instrument cases. The systems include mechanically adjustable end pieces that are able to secure a wide variety of musical instruments within musical instrument cases.

Abstract: Methods and apparatus to align applique cutters are disclosed. A disclosed example alignment rail is for use with cutting an applique relative to a surface of a vehicle. The example alignment rail includes a base to contact the surface. The example alignment rail also includes a body including a cross-sectional profile extending along a longitudinal axis of the alignment rail. The example alignment rail also includes a groove of the cross-sectional profile extending along the longitudinal axis, where the groove is to align movement of a cutting tool to cut the applique.

Abstract: Systems for raising pads on musical instruments to enable drying of pads and increase air flow around the pad and a body of the musical instrument. A vent spanner device, including a positioning feature and a retention feature, is placed between a pad and its corresponding vent to create an air gap. A pad prop is placed against a key mechanism or between the key mechanism and/or the body to raise a pad from sealing its corresponding vent. A linkage feature connects one or more vent spanners, pad props, end pieces, key mechanisms, or the body, and provides storage.

Abstract: Systems for raising pads on musical instruments to enable drying of pads and increase air flow around the pad and a body of the musical instrument. A vent spanner device, including a positioning feature and a retention feature, is placed between a pad and its corresponding vent to create an air gap. A pad prop is placed against a key mechanism or between the key mechanism and/or the body to raise a pad from sealing its corresponding vent. A linkage feature connects one or more vent spanners, pad props, end pieces, key mechanisms, or the body, and provides storage.

Abstract: Systems for raising pads on musical instruments to enable drying of pads and increase air flow around the pad and a body of the musical instrument. A vent spanner device, including a positioning feature and a retention feature, is placed between a pad and its corresponding vent to create an air gap. A pad prop is placed against a key mechanism or between the key mechanism and/or the body to raise a pad from sealing its corresponding vent. A linkage feature connects one or more vent spanners, pad props, end pieces, key mechanisms, or the body, and provides storage.

Abstract: Systems for raising pads on musical instruments to enable drying of pads and increase air flow around the pad and a body of the musical instrument. A vent spanner device, including a positioning feature and a retention feature, is placed between a pad and its corresponding vent to create an air gap. A pad prop is placed against a key mechanism or between the key mechanism and/or the body to raise a pad from sealing its corresponding vent. A linkage feature connects one or more vent spanners, pad props, end pieces, key mechanisms, or the body, and provides storage.

Abstract: Thrust-reverser assemblies that utilize active flow-control and systems and methods including the same are disclosed herein. The thrust-reverser assemblies define a forward-thrust configuration and a reverse-thrust configuration. The thrust-reverser assemblies include a bullnose fairing that defines a portion of a reverser duct and an active flow-control device. The active flow-control device is located to energize a boundary layer fluid flow within a boundary layer that is adjacent to the bullnose fairing to resist separation of the boundary layer from the bullnose fairing when the thrust-reverser assembly is in the reverse-thrust configuration. The methods include flowing a thrust-reverser fluid stream through the reverser duct to generate the boundary layer and energizing a boundary layer fluid flow within the boundary layer with an active flow-control device to resist separation of the boundary layer from the bullnose fairing.