Abstract: Synthetic Notch receptors can be activated by ligands presented in different ways from a material, thereby serving as a general platform for generating new user-defined material-to-cell signaling pathways. Synthetic signals can be embedded directly into ECM proteins via genetic engineering of ECM-producing fibroblasts, on materials in 2D via microcontact printing or other micropatterning methods, and in 3D with immobilization such as covalent linking to hydrogels, in user-defined spatial patterns. Hence these material-to-cell pathways were used to spatially control activation of user-defined genetic programs in 2D and 3D. Since multiple synthetic pathways with different specificity can be engineered in a single cell, multicellular population can be patterned in up to three spatial domains of gene expression. We co-transdifferentiated fibroblasts into skeletal muscle or endothelial cell precursors in user-defined spatial patterns.

Abstract: A drawer system includes a drawer and a drawer cover. The drawer can include an open top and be configured to be supported at a supporting structure, such as a refrigerator fresh food compartment for example, for selective sliding movement outwardly from the supporting structure and sliding movement inwardly toward the supporting structure. The drawer cover can be configured to be mounted at the supporting structure in engagement with the drawer at the open top of the drawer for movement directly vertically upwardly at the supporting structure away from the open top of the drawer when the drawer is moved outwardly from the supporting structure and for movement directly vertically downwardly at the supporting structure toward the open top of the drawer when the drawer is moved inwardly toward the supporting structure.

Abstract: A drawer system includes a drawer and a drawer cover. The drawer can include an open top and be configured to be supported at a supporting structure, such as a refrigerator fresh food compartment for example, for selective sliding movement outwardly from the supporting structure and sliding movement inwardly toward the supporting structure. The drawer cover can be configured to be mounted at the supporting structure in engagement with the drawer at the open top of the drawer for movement directly vertically upwardly at the supporting structure away from the open top of the drawer when the drawer is moved outwardly from the supporting structure and for movement directly vertically downwardly at the supporting structure toward the open top of the drawer when the drawer is moved inwardly toward the supporting structure.