Patents by Inventor Nathan Collins
Nathan Collins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11965004Abstract: Disclosed are compositions comprising an antibody conjugated to one or more molecular guidance system (MGS) peptides. Disclosed are methods of treating a subject in need thereof comprising administering to the subject in need thereof an effective amount of an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target involved in the disease process. Disclosed are methods of targeting an intracellular target comprising administering an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target.Type: GrantFiled: July 10, 2018Date of Patent: April 23, 2024Assignee: SRI InternationalInventors: Kathlynn C. Brown, Nathan Collins, Shunzi “Susan” Li, Curtis Allred, Keen Chung, Michael McGuire
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Patent number: 11961595Abstract: Retrosynthetic methods are described for determining one or more optimal synthetic routes to generate a target compound.Type: GrantFiled: January 30, 2019Date of Patent: April 16, 2024Assignee: SRI INTERNATIONALInventors: Peter Madrid, Nathan Collins, Mario Latendresse, Jeremiah Malerich, Markus Krummenacker
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Patent number: 11911191Abstract: A system for containing and transporting a medical device may include a container including a bottom face and surrounding side faces as a closed first end and an open second end to form an inner portion for receiving and retaining the medical device. At least a portion of one or more of the side faces may have an indentation extending along a length of the respective side face. A liner and cover may be removably enclosable about the container. The liner may be extendable over the side faces to line the inner portion of the container. The cover may enclose the medical device in the container between the liner and cover. The indentation may be formed into the inner portion of the container. The container may be compatibly receivable in a first transportation device in a first orientation.Type: GrantFiled: December 16, 2020Date of Patent: February 27, 2024Assignee: Boston Scientific Scimed, Inc.Inventors: Nathan T. Cummings, Jenny Dandin, Michele E. Dalena, Alyson Borzillo, Ryan LaFlamme, Joshua Talsky, Mark Collins, John LaRoi
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Patent number: 11885822Abstract: Embodiments in accordance with the present disclosure are directed to apparatuses used for reaction screening and optimization purposes. An example apparatus includes a plurality of reaction vessels, a dispensing subsystem, at least one reactor module, an analysis subsystem, an automation subsystem, and control circuitry. The dispensing subsystem delivers reagents to the plurality of reaction vessels for a plurality of reaction mixtures having varied reaction conditions. The at least one reactor module drives a plurality of reactions within the plurality of reaction vessels. The analysis subsystem analyzes compositions contained in the plurality of reaction vessels. The automation subsystem selectively moves the plurality of reaction vessels from a location proximal to the dispensing subsystem to the at least one reactor module based on experimental design parameters. And, the control circuitry identifies optimum reaction conditions for a target end product based on the analysis.Type: GrantFiled: June 29, 2018Date of Patent: January 30, 2024Assignee: SRI InternationalInventors: Nathan Collins, Jeremiah Malerich, Jason D. White, Kevin Luebke, Kristina Rucker, Brian McCoy
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Publication number: 20230397931Abstract: Systems and methods for preventing the seeding of cancerous cells during morcellation of a tissue specimen inside a patient's body and removal of the tissue specimen from inside the patient through a minimally-invasive body opening to outside the patient are provided. One system includes a cut-resistant tissue guard removably insertable into a containment bag. The tissue specimen is isolated and contained within the containment bag and the guard is configured to protect the containment bag and surrounding tissue from incidental contact with sharp instrumentation used during morcellation and extraction of the tissue specimen. The guard is adjustable for easy insertion and removal and configured to securely anchor to the body opening. Protection-focused and containment-based systems for tissue removal are provided that enable minimally invasive procedures to be performed safely and efficiently.Type: ApplicationFiled: August 29, 2023Publication date: December 14, 2023Inventors: Serene Wachli, Tracy Breslin, Steven C. Kessler, Nikolai Poulsen, Nathan Collins, Alexandra Do, Eduardo Bolanos, Boun Pravong, Patrick Elliott, Matthew Wixey, Wayne Young, Jacob J. Filek, Kevin B. Castelo, Adam Hoke, Gregory K. Hofstetter, Jacqueline DeMarchi, Amy Garces, Heidi Holmes, Alexander Sheehan
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Publication number: 20230393140Abstract: An example binding assay includes a plurality of sub-regions, a plurality of synthetic compounds on beads, wherein each of the plurality of sub-regions includes one of the plurality of synthetic compounds, a biological target labeled with a first detectable label in each of the plurality sub-regions, and a biological counter target labeled with a second detectable label in each of the plurality of sub-regions. The biological counter target is configured to bind to the biological target when the biological target is in a first orientation. And, wherein a first subset of the plurality of synthetic compounds bind to the biological target and effect interactions between the biological target and the biological counter target.Type: ApplicationFiled: October 15, 2021Publication date: December 7, 2023Applicant: SRI InternationalInventors: Peter Madrid, Nathan Collins, Michal Avital-Shmilovici, Xiaohe Liu, Thomas Shaler
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Patent number: 11737782Abstract: Systems and methods for preventing the seeding of cancerous cells during morcellation of a tissue specimen inside a patient's body and removal of the tissue specimen from inside the patient through a minimally-invasive body opening to outside the patient are provided. One system includes a cut-resistant tissue guard removably insertable into a containment bag. The tissue specimen is isolated and contained within the containment bag and the guard is configured to protect the containment bag and surrounding tissue from incidental contact with sharp instrumentation used during morcellation and extraction of the tissue specimen. The guard is adjustable for easy insertion and removal and configured to securely anchor to the body opening. Protection-focused and containment-based systems for tissue removal are provided that enable minimally invasive procedures to be performed safely and efficiently.Type: GrantFiled: April 27, 2021Date of Patent: August 29, 2023Assignee: Applied Medical Resources CorporationInventors: Serene Wachli, Tracy Breslin, Steven C. Kessler, Nikolai Poulsen, Nathan Collins, Alexandra Do, Eduardo Bolanos, Boun Pravong, Patrick Elliott, Matthew Wixey, Wayne Young, Jacob J. Filek, Kevin B. Castelo, Adam Hoke, Gregory K. Hofstetter, Jacqueline DeMarchi, Amy Garces, Heidi Holmes, Alexander Sheehan
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Publication number: 20230174485Abstract: Various embodiments of the present disclosure are directed to compounds having Formula (I), Formula (IA), Formula (IB), Formula (IC), Formula (ID), Formula (IE), and/or pharmaceutically acceptable salts thereof. The compounds can be suitable for inhibiting lipoxygenases, and/or treating associated diseases, such as Alzheimer's disease. In some embodiments, the compounds may be administered to a patient as part of a pharmaceutical formulation.Type: ApplicationFiled: March 25, 2021Publication date: June 8, 2023Applicant: SRI InternationalInventors: Ling Jong, Raymond Ng, Nathan Collins
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Publication number: 20230157723Abstract: Systems and methods for preventing the seeding of cancerous cells during morcellation of a tissue specimen inside a patient's body and removal of the tissue specimen from inside the patient through a minimally-invasive body opening to outside the patient are provided. One system includes a cut-resistant tissue guard removably insertable into a containment bag. The tissue specimen is isolated and contained within the containment bag and the guard is configured to protect the containment bag and surrounding tissue from incidental contact with sharp instrumentation used during morcellation and extraction of the tissue specimen. The guard is adjustable for easy insertion and removal and configured to securely anchor to the body opening. Protection-focused and containment-based systems for tissue removal are provided that enable minimally invasive procedures to be performed safely and efficiently.Type: ApplicationFiled: January 10, 2023Publication date: May 25, 2023Inventors: Serene Wachli, Tracy Breslin, Steven C. Kessler, Nikolai Poulsen, Nathan Collins, Alexandra Do, Eduardo Bolanos, Boun Pravong, Patrick Elliott, Matthew A. Wixey, Wayne Young, Jacob J. Filek, Kevin B. Castelo, Adam Hoke, Gregory K. Hofstetter, Jacqueline DeMarchi, Amy Garces, Heidi Holmes, Alexander Sheehan
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Patent number: 11639326Abstract: This disclosure generally relates to methods of making ibuprofen, naproxen, and derivatives thereof. This disclosure also generally relates to compounds made by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: April 6, 2018Date of Patent: May 2, 2023Assignee: SRI InternationalInventors: Nathan Collins, Jeremiah Malerich, Judy Szeto, Joseph A. Kozocas
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Publication number: 20230117592Abstract: Various embodiments of the present disclosure are directed to compounds having Formula I, Formula II, Formula IIA, Formula III, Formula IIIA, Formula IIIB, and/or pharmaceutically acceptable salts thereof. The compounds can be suitable for inhibiting lipoxygenases and/or treating associated diseases. In some embodiments, subject compounds are used to prepare a composition that is effective in treating neurodegenerative diseases.Type: ApplicationFiled: December 18, 2020Publication date: April 20, 2023Applicant: SRI InternationalInventors: Ling Jong, Nathan Collins, Raymond Ng
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Patent number: 11547444Abstract: Systems and methods for preventing the seeding of cancerous cells during morcellation of a tissue specimen inside a patient's body and removal of the tissue specimen from inside the patient through a minimally-invasive body opening to outside the patient are provided. One system includes a cut-resistant tissue guard removably insertable into a containment bag. The tissue specimen is isolated and contained within the containment bag and the guard is configured to protect the containment bag and surrounding tissue from incidental contact with sharp instrumentation used during morcellation and extraction of the tissue specimen. The guard is adjustable for easy insertion and removal and configured to securely anchor to the body opening. Protection-focused and containment-based systems for tissue removal are provided that enable minimally invasive procedures to be performed safely and efficiently.Type: GrantFiled: November 23, 2020Date of Patent: January 10, 2023Assignee: Applied Medical Resources CorporationInventors: Serene Wachli, Tracy Breslin, Steven C. Kessler, Nikolai Poulsen, Nathan Collins, Alexandra Do, Eduardo Bolanos, Boun Pravong, Patrick Elliott, Matthew A. Wixey, Wayne Young, Jacob J. Filek, Kevin B. Castelo, Adam Hoke, Gregory K. Hofstetter, Jacqueline DeMarchi, Amy Garces, Heidi Holmes, Alexander Sheehan
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Publication number: 20220227823Abstract: Disclosed are compositions comprising an antibody conjugated to one or more molecular guidance system (MGS) peptides. Disclosed are methods of treating a subject in need thereof comprising administering to the subject in need thereof an effective amount of an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target involved in the disease process. Disclosed are methods of targeting an intracellular target comprising administering an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target.Type: ApplicationFiled: July 10, 2018Publication date: July 21, 2022Inventors: Kathlynn C. Brown, Nathan Collins, Shunzi "Susan" Li, Curtis Allred, Keen Chung, Michael McGuire
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Publication number: 20210259733Abstract: Systems and methods for preventing the seeding of cancerous cells during morcellation of a tissue specimen inside a patient's body and removal of the tissue specimen from inside the patient through a minimally-invasive body opening to outside the patient are provided. One system includes a cut-resistant tissue guard removably insertable into a containment bag. The tissue specimen is isolated and contained within the containment bag and the guard is configured to protect the containment bag and surrounding tissue from incidental contact with sharp instrumentation used during morcellation and extraction of the tissue specimen. The guard is adjustable for easy insertion and removal and configured to securely anchor to the body opening. Protection-focused and containment-based systems for tissue removal are provided that enable minimally invasive procedures to be performed safely and efficiently.Type: ApplicationFiled: April 27, 2021Publication date: August 26, 2021Inventors: Serene Wachli, Tracy Breslin, Steven C. Kessler, Nikolai Poulsen, Nathan Collins, Alexandra Do, Eduardo Bolanos, Boun Pravong, Patrick Elliott, Matthew Wixey, Wayne Young, Jacob J. Filek, Kevin B. Castelo, Adam Hoke, Gregory K. Hofstetter, Jacqueline DeMarchi, Amy Garces, Heidi Holmes, Alexander Sheehan
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Publication number: 20210208157Abstract: Devices, systems and methods for affinity reagent and catalyst discovery employing a library on a bead HTS platform, each bead comprising affixed non-natural polymers of a distinct bioactive monomer with sequence pre-defined branching and folding in tertiary structures, and fiber-optic array scanning technology.Type: ApplicationFiled: February 2, 2021Publication date: July 8, 2021Inventors: Nathan Collins, Peter B. Madrid
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Patent number: 10987132Abstract: Systems and methods for preventing the seeding of cancerous cells during morcellation of a tissue specimen inside a patient's body and removal of the tissue specimen from inside the patient through a minimally-invasive body opening to outside the patient are provided. One system includes a cut-resistant tissue guard removably insertable into a containment bag. The tissue specimen is isolated and contained within the containment bag and the guard is configured to protect the containment bag and surrounding tissue from incidental contact with sharp instrumentation used during morcellation and extraction of the tissue specimen. The guard is adjustable for easy insertion and removal and configured to securely anchor to the body opening. Protection-focused and containment-based systems for tissue removal are provided that enable minimally invasive procedures to be performed safely and efficiently.Type: GrantFiled: January 10, 2019Date of Patent: April 27, 2021Assignee: Applied Medical Resources CorporationInventors: Serene Wachli, Tracy Breslin, Steven C. Kessler, Nikolai Poulsen, Nathan Collins, Alexandra Do, Eduardo Bolanos, Boun Pravong, Patrick Elliott, Matthew Wixey, Wayne Young, Jacob J. Filek, Kevin B. Castelo, Adam Hoke, Gregory K. Hofstetter, Jacqueline DeMarchi, Amy Garces, Heidi Holmes, Alexander Sheehan
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Publication number: 20210114962Abstract: This disclosure generally relates to methods of making ibuprofen, naproxen, and derivatives thereof. This disclosure also generally relates to compounds made by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: April 6, 2018Publication date: April 22, 2021Inventors: Nathan Collins, Jeremiah Malerich, Judy Szeto, Joseph A. Kozocas
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Publication number: 20210085364Abstract: Systems and methods for preventing the seeding of cancerous cells during morcellation of a tissue specimen inside a patient's body and removal of the tissue specimen from inside the patient through a minimally-invasive body opening to outside the patient are provided. One system includes a cut-resistant tissue guard removably insertable into a containment bag. The tissue specimen is isolated and contained within the containment bag and the guard is configured to protect the containment bag and surrounding tissue from incidental contact with sharp instrumentation used during morcellation and extraction of the tissue specimen. The guard is adjustable for easy insertion and removal and configured to securely anchor to the body opening. Protection-focused and containment-based systems for tissue removal are provided that enable minimally invasive procedures to be performed safely and efficiently.Type: ApplicationFiled: November 23, 2020Publication date: March 25, 2021Inventors: Serene Wachli, Tracy Breslin, Steven C. Kessler, Nikolai Poulsen, Nathan Collins, Alexandra Do, Eduardo Bolanos, Boun Pravong, Patrick Elliott, Matthew A. Wixey, Wayne Young, Jacob J. Filek, Kevin B. Castelo, Adam Hoke, Gregory K. Hofstetter, Jacqueline DeMarchi, Amy Garces, Heidi Holmes, Alexander Sheehan
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Publication number: 20210065851Abstract: Retrosynthetic methods are described for determining one or more optimal synthetic routes to generate a target compound.Type: ApplicationFiled: January 30, 2019Publication date: March 4, 2021Inventors: Peter Madrid, Nathan Collins, Mario Latendresse, Jeremiah Malerich, Markus Krummenacker
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Publication number: 20210065848Abstract: Embodiments in accordance with the present disclosure are directed to polymer beads and uses thereof, including forming libraries of compounds for screening and assay purposes. An example method includes using logic circuitry to: select a plurality of molecules that include a plurality of subgroups, each of the plurality of molecules exhibiting a mass spectrometry characteristic that is distinguishable from mass spectrometry characteristics of other molecules of the plurality, and assign the plurality of molecules with a position in a sequence of a plurality of synthetic compounds forming a library. The method further includes defining, as data in a memory circuit of the logic circuitry, the plurality of synthetic compounds that are sequenceable via mass spectrometry using the assigned positions of the plurality of molecules for communicating to other circuitry for formation thereof via coupling chemistry or screening of a particular function.Type: ApplicationFiled: September 5, 2017Publication date: March 4, 2021Inventors: Peter Madrid, Nathan Collins, Michal Avital-Shmilovici, Pauline Bourbon, Thomas Shaler