Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: A technique may include receiving, by a management service a plurality of instance configurations from a client device. The technique may then include receiving, by the management service, information identifying a launch request for a compute instance. The technique may include determining, by the management service, one or more candidate shapes for the compute instance based at least in part on the plurality of instance configurations. The technique may include selecting, by the management service and from the one or more candidate shapes, a launch shape for the compute instance and launching the compute instance using the launch shape. The technique may then include providing, the client device access to the compute instance, launched based on the launch shape.

Abstract: A device for securing soft tissue to bone includes a suture anchor, a first suture portion, a second suture portion and a working suture. The suture anchor has a lumen therethrough. The first suture portion has a length extending from a first end to a second end and passes into and out of the lumen over at least part of the length moving toward the second end from the first end. The second suture portion has a length extending from a first end to a second end and is disposed relative to the suture anchor such that at least part of the second suture portion encircles the suture anchor circumferentially around an outer surface of the suture anchor at least one complete rotation. The working suture has a first end operatively connected to at least one of the suture anchor, the first suture portion and the second suture portion.

Abstract: The invention relates to an improved method of double row tissue repair with a graft or patch at the repair site for various applications of arthroscopic surgery requiring tissue to bone attachment. The method includes a patch and one or more knotless, adjustable anchor systems that allow for knotless adjustability of the patch relative to the bone-tissue interface for proper positioning and securement of the patch at the repair site.

Abstract: Closed Suture Anchor construct and/or assembly having one or more anchoring constructs enclosed by a continuous (i.e., closed) loop of a suture or suture, such as ultra high molecular weight polyethylene (UHMWPE) are disclosed herein. Preferred assemblies are constructed such that the anchoring construct cannot be detached from the continuous loop without breaking or opening the continuous or closed loop of the closed suture anchor construct.

Abstract: The embodiments disclosed herein are breakaway suture constructs containing releasable locking connections and/or methods of assembly that allow a plurality of sutures, and/or suture ends to be attached or connected together along a portion of their length to form a spliced region that unifies the sutures or suture ends and prevent movement of a suture end relative to other suture end. The releasable connections allow the surgeon to easily manipulate the spliced suture ends with little or no force to result in the unified ends of the sutures to be separated without requiring cutting or severing of the individual sutures or the releasable locking connections.

Abstract: An expandable device for attachment to a portable electronic device having first and second surfaces includes a button having a top side, a bottom side, and a coupling portion and further includes an elongated body having a top side, a bottom side, and a platform coupling portion. The button is movable between an expanded position and a collapsed position. The bottom side of the platform engages a portion of the portable electronic device and the platform coupling portion engages the coupling portion of the button. When coupled to the positioning platform, the button is movable between a first position where the button is positioned along the first surface of the portable electronic device and a second position where the button is positioned along the second surface of the portable electronic device.

Abstract: An accessory attachment device includes a platform having top and bottom sides, an elongated length, a platform height dimension, and at least one engaging region that engages an outer edge of the portable electronic device or a case thereof. The platform height dimension is less than a device height dimension of the portable electronic device.

Abstract: A mixing paddle configured for use with a gravimetric blender. The mixing paddle has a first rotor; a second rotor spaced axial from the first rotor; and at least one mixing blade disposed between the first rotor and the second rotor. The at least one mixing blade of the mixing paddle includes an inner edge having a first sloped portion and a second sloped portion directed inward toward a middle portion of the at least one mixing blade. The mixing blade is configured to be narrower in the middle portion between the outer edge and the inner edge than at a first end and second end.

Abstract: A mixing paddle configured for use with a gravimetric blender. The mixing paddle has a first rotor; a second rotor spaced axial from the first rotor; and at least one mixing blade disposed between the first rotor and the second rotor. The at least one mixing blade of the mixing paddle includes an inner edge having a first sloped portion and a second sloped portion directed inward toward a middle portion of the at least one mixing blade. The mixing blade is configured to be narrower in the middle portion between the outer edge and the inner edge than at a first end and second end.

Abstract: A cargo containment apparatus is formed from a series of individual panels linked together to permit deployment in a variety of configurations for containing cargo items within a larger cargo area of an automotive vehicle. The linked panels of the cargo containment apparatus are pivotable relative to one another to permit substantial flexibility in the apparatus to attain a shape that corresponds to the items to be transported in the cargo area. The panels are can be formed with bag hooks that can be engaged with the handles of conventional plastic grocery bags and tote bags for effectively restraining movement thereof within the automotive cargo area. Pins on the bottom surfaces of the panels engage the carpet in the automotive cargo area to restrict the movement of the cargo containment apparatus within the automotive cargo area.

Abstract: A cargo containment apparatus is formed from a series of individual panels linked together to permit deployment in a variety of configurations for containing cargo items within a larger cargo area of an automotive vehicle. The linked panels of the cargo containment apparatus are pivotable relative to one another to permit substantial flexibility in the apparatus to attain a shape that corresponds to the items to be transported in the cargo area. The panels are can be formed with bag hooks that can be engaged with the handles of conventional plastic grocery bags and tote bags for effectively restraining movement thereof within the automotive cargo area. Pins on the bottom surfaces of the panels engage the carpet in the automotive cargo area to restrict the movement of the cargo containment apparatus within the automotive cargo area.