Abstract: The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

Abstract: Artificial intelligence (AI) technology can be used in combination with composable communication goal statements to facilitate a user's ability to quickly structure story outlines in a manner usable by an NLG narrative generation system without any need for the user to directly author computer code. Narrative analytics that are linked to communication goal statements can employ a conditional outcome framework that allows the content and structure of resulting narratives to intelligently adapt as a function of the nature of the data under consideration. This AI technology permits NLG systems to determine the appropriate content for inclusion in a narrative story about a data set in a manner that will satisfy a desired communication goal.

Abstract: The disclosure provides methods for removing polymeric fouling on process equipment during low density polyethylene manufacture. A purge cleaning composition with ethylene gas containing at least one C3+ hydrocarbon alkene for a period of time is used to remove polymer build-up in at least one location in the polymerization plant, such as, without limitation, the reactor or in tubing between a reactor and a pre-heater or between a cooler and a preheater.

Abstract: Systems, methods and apparatus are provided for bi-directional I/O bandwidth enhancement via capacitive reactance reduction. An example apparatus can comprise a first signal driver of a transceiver, a second signal driver of the transceiver, an input/output (I/O) pad, and a y-coil, wherein the y-coil includes a first inductor coupled to the first signal driver of the transceiver, a second inductor coupled to the second signal driver of the transceiver, and a third inductor coupled to the I/O pad.

Abstract: A signal transmission system comprises an optical fiber cable, an electrical-to-optical signal converter, and an optical signal receiver. The optical fiber cable extending through a vehicle. The electrical-to-optical signal converter is connected to a first end of the optical fiber cable and is connected an antenna. The optical signal converter, when operating, receives a radio frequency signal from the antenna; modulates an optical signal using the radio frequency signal to create a modulated optical signal; and transmits the modulated optical signal through the optical fiber cable from the first end. The optical signal receiver is connected to a second end of the optical fiber cable, wherein the optical signal receiver, when operating, converts the modulated optical signal into a data signal.

Abstract: Antibodies that bind to HIV gp120 and neutralize HIV are disclosed. Also disclosed are methods of using such antibodies alone or in combination with other therapeutic agents to treat or prevent HIV infection.

Abstract: A system is provided for controlling operations of at least two motors on a watercraft on a body of water. The system comprises a kicker motor, a trolling motor, one or more processors, and memory including computer program code. The computer program code is configured to, when executed, cause the one or more processors to receive an indication regarding a current mode of operation for the watercraft, determine, based on the current mode, a first setting for the kicker motor, and determine, based on the current mode, a second setting for the trolling motor. The computer program code is also configured to, when executed, cause the one or more processors to cause (i) the kicker motor to operate according to the first setting, and (ii) the trolling motor to operate according to the second setting so as to cause the watercraft to operate according to the current mode.

Abstract: The present invention provides compounds of Formula I?, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

Abstract: A vehicle lidar network comprising vehicles and lidar systems in the vehicles. The lidar systems are configured to emit laser beams having a number of electromagnetic properties in which the number of electromagnetic properties is selected to reduce interference caused by the laser beams emitted from other lidar systems.

Abstract: An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. A sheath or needle may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via a sheath or needle.

Abstract: Artificial intelligence (AI) technology can be used in combination with composable communication goal statements to facilitate a user's ability to quickly structure story outlines in a manner usable by an NLG narrative generation system without any need for the user to directly author computer code. Narrative analytics that are linked to communication goal statements can employ a conditional outcome framework that allows the content and structure of resulting narratives to intelligently adapt as a function of the nature of the data under consideration. This AI technology permits NLG systems to determine the appropriate content for inclusion in a narrative story about a data set in a manner that will satisfy a desired communication goal.

Abstract: A laser wind tunnel turbulent airflow detection system comprising a laser sensor system and a controller. The laser sensor system is configured to emit laser beams in a wind tunnel from transmitter locations. The laser sensor system is configured to detect the laser beams at receiver locations. The controller is configured to emit the laser beams from the transmitter locations to the receiver locations using the laser sensor system. The controller is configured to determine beat frequencies of the laser beams detected by the laser sensor system at the receiver locations. The controller is configured to determine air turbulence in the wind tunnel for the receiver locations using the beat frequencies.

Abstract: Systems and methods are disclosed herein for influencing mission planning, vehicle maintenance, and identifying an aerial vehicle that provide a greatest probability of mission success. In some examples, a dynamic reliability model of dynamic reliability models can be updated based on at least component reliability data indicative of a reliability of a component of the aerial vehicle of aerial vehicles. Each dynamic reliability model can characterize a reliability of one of the aerial vehicles. Each dynamic reliability model can be executed to compute an indication of vehicle reliability for each aerial vehicle. A mission of success probability for each aerial vehicle can be computed based on a respective indication of vehicle reliability. A given aerial vehicle of the aerial vehicles can be identified for implementing the mission based on an evaluation of the mission of success probability for each aerial vehicle of the aerial vehicles.

Abstract: A method for using a bioreactor-based system includes circulating a volume including a cell population through a space in a first direction for a first period, the space having a first orientation for the first period; circulating the volume in a second direction for a second period, the space having the first orientation for the second period; circulating the volume in the first direction for a third period, the space having a second orientation for the third period; and circulating the volume in the second direction for a fourth period, the space having the second orientation for the fourth period. The method further includes maintaining a culture medium in the space using bidirectional movement at a first rate, causing the culture medium to move through the space at a second rate that is less than the first rate, and causing a washing fluid to move through the space.

Abstract: An air vehicle management system comprising a controller for an air vehicle. The controller is configured to determine a prediction of an acceleration using an air vehicle model system and backscatter data. The air vehicle model system is trained to predict the acceleration using the backscatter data and is generated using backscatter light detected from emitting a laser beam in an atmosphere in a direction ahead of the air vehicle. The controller is configured to determine an adjustment to a number of flight control settings for the air vehicle that reduces a stress on the air vehicle using the prediction of the acceleration. The controller is configured to adjust the number of flight control settings using the adjustment.

Abstract: Disclosed herein is computer technology that provides adaptive mechanisms for learning concepts that are expressed by natural language sentences, and then applies this learning to appropriately classify new natural language sentences with the relevant concept that they express.

Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: A hydroacoustic wave detection system that comprises a time delay generator and a hydroacoustic wave detector. The time delay generator is connected to an end of an underwater cable in which light signals travel in an optical fiber system in the underwater cable. The time delay generator is configured to introduce a time delay in the light signals received by the time delay generator to generate delayed light signals. The hydroacoustic wave detector is configured to control the time delay generator to generate a number of time delays. The hydroacoustic wave detector is configured to detect a presence of hydroacoustic waves for an event (e.g. underwater earthquake, underwater volcano, whale call) from an interferometric response determined using the light signals transmitted and the delayed light signals received. The hydroacoustic waves impinge on the underwater cable at a perturbation location along the underwater cable.

Abstract: Self-propelled vehicles for supporting and operating a device are disclosed. Example devices include agricultural devices. The vehicle includes mounting arms that allow the device to be extended forward or rearward of the vehicle. In some embodiments, the device is releasably coupleable to the vehicle. In some embodiments, the vehicle includes rear drive wheels and front caster wheels.