Abstract: A generator comprising an interface and a control circuit is disclosed. The interface is to electrically couple to an ultrasonic surgical instrument comprising a switch. The switch is configurable between a first switch state and a second switch state. The control circuit is to provide a continuous drive signal to the ultrasonic surgical instrument based on the switch being in the first switch state. The control circuit is to provide a pulsed drive signal to the ultrasonic surgical instrument based on the switch being in the second switch state.

Abstract: A signature of proteins occurring in glioblastoma multiforme (GBM) tissue comprised of 33 cell surface proteins (GBMSig) that distinguish subjects with GBM from healthy controls with more than 98% accuracy is described. In addition, four of the members of this signature are particularly useful as blood-borne markers of GBM. Certain other members of the signature are indicators of the possible efficacy of the use of TGF-?1 inhibitors in the treatment of this condition. Methods to treat and to stratify GBM based on GBMSig proteins are also disclosed.

Abstract: The invention provides methods to identify various types of brain cancer tissue by comparing gene expression transcriptomes in tissue samples. A sequential method to discriminate among six different types of brain cancer is described. The invention relates to the field of markers for various types of brain cancer. More particularly, it relies on a sequential system for sorting individual cancer types.