Patents by Inventor Nathan J. Hillson
Nathan J. Hillson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11749379Abstract: The present invention provides a method of a method of designing an implementation of a DNA assembly. In an exemplary embodiment, the method includes (1) receiving a list of DNA sequence fragments to be assembled together and an order in which to assemble the DNA sequence fragments, (2) designing DNA oligonucleotides (oligos) for each of the DNA sequence fragments, and (3) creating a plan for adding flanking homology sequences to each of the DNA oligos. In an exemplary embodiment, the method includes (1) receiving a list of DNA sequence fragments to be assembled together and an order in which to assemble the DNA sequence fragments, (2) designing DNA oligonucleotides (oligos) for each of the DNA sequence fragments, and (3) creating a plan for adding optimized overhang sequences to each of the DNA oligos.Type: GrantFiled: June 7, 2019Date of Patent: September 5, 2023Assignee: The Regents of the University of CaliforniaInventor: Nathan J. Hillson
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Publication number: 20200005891Abstract: The present invention provides a method of a method of designing an implementation of a DNA assembly. In an exemplary embodiment, the method includes (1) receiving a list of DNA sequence fragments to be assembled together and an order in which to assemble the DNA sequence fragments, (2) designing DNA oligonucleotides (oligos) for each of the DNA sequence fragments, and (3) creating a plan for adding flanking homology sequences to each of the DNA oligos. In an exemplary embodiment, the method includes (1) receiving a list of DNA sequence fragments to be assembled together and an order in which to assemble the DNA sequence fragments, (2) designing DNA oligonucleotides (oligos) for each of the DNA sequence fragments, and (3) creating a plan for adding optimized overhang sequences to each of the DNA oligos.Type: ApplicationFiled: June 7, 2019Publication date: January 2, 2020Inventor: Nathan J. Hillson
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Patent number: 10373703Abstract: The present invention provides a method of a method of designing an implementation of a DNA assembly. In an exemplary embodiment, the method includes (1) receiving a list of DNA sequence fragments to be assembled together and an order in which to assemble the DNA sequence fragments, (2) designing DNA oligonucleotides (oligos) for each of the DNA sequence fragments, and (3) creating a plan for adding flanking homology sequences to each of the DNA oligos. In an exemplary embodiment, the method includes (1) receiving a list of DNA sequence fragments to be assembled together and an order in which to assemble the DNA sequence fragments, (2) designing DNA oligonucleotides (oligos) for each of the DNA sequence fragments, and (3) creating a plan for adding optimized overhang sequences to each of the DNA oligos.Type: GrantFiled: May 5, 2016Date of Patent: August 6, 2019Assignee: The Regents of the University of CaliforniaInventor: Nathan J. Hillson
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Patent number: 10131903Abstract: This invention provides methods and compositions for assembling biological constructs (e.g., plasmids, transformed cells, etc.). In certain embodiments the methods involve encapsulating separate components of the biological construct each in a fluid droplet confined in a fluid channel; optionally mixing droplets from different fluid channels to form a sequenced order of droplets carrying different components of the biological construct in a channel or chamber; and optionally combining two or more droplets each containing different components of the biological construct to permit the components to react with each other in one or more reactions contributing to the assembly of the biological construct.Type: GrantFiled: April 2, 2012Date of Patent: November 20, 2018Assignees: The Regents of the University of California, Sandia CorporationInventors: Chieh Chang, Rajiv Bharadwaj, Anup K. Singh, Aarthi Chandrasekaran, Nathan J. Hillson
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Publication number: 20160378913Abstract: The present invention provides a method of a method of designing an implementation of a DNA assembly. In an exemplary embodiment, the method includes (1) receiving a list of DNA sequence fragments to be assembled together and an order in which to assemble the DNA sequence fragments, (2) designing DNA oligonucleotides (oligos) for each of the DNA sequence fragments, and (3) creating a plan for adding flanking homology sequences to each of the DNA oligos. In an exemplary embodiment, the method includes (1) receiving a list of DNA sequence fragments to be assembled together and an order in which to assemble the DNA sequence fragments, (2) designing DNA oligonucleotides (oligos) for each of the DNA sequence fragments, and (3) creating a plan for adding optimized overhang sequences to each of the DNA oligos.Type: ApplicationFiled: May 5, 2016Publication date: December 29, 2016Inventor: Nathan J. Hillson
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Patent number: 9361427Abstract: The present invention provides a method of a method of designing an implementation of a DNA assembly. In an exemplary embodiment, the method includes (1) receiving a list of DNA sequence fragments to be assembled together and an order in which to assemble the DNA sequence fragments, (2) designing DNA oligonucleotides (oligos) for each of the DNA sequence fragments, and (3) creating a plan for adding flanking homology sequences to each of the DNA oligos. In an exemplary embodiment, the method includes (1) receiving a list of DNA sequence fragments to be assembled together and an order in which to assemble the DNA sequence fragments, (2) designing DNA oligonucleotides (oligos) for each of the DNA sequence fragments, and (3) creating a plan for adding optimized overhang sequences to each of the DNA oligos.Type: GrantFiled: February 1, 2012Date of Patent: June 7, 2016Assignee: The Regents of the University Of CaliforniaInventor: Nathan J. Hillson
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Patent number: 8697388Abstract: Compositions and methods are provided for detection of certain heavy metals using bacterial whole cell biosensors.Type: GrantFiled: February 6, 2008Date of Patent: April 15, 2014Assignee: U.S. Department of EnergyInventors: Nathan J. Hillson, Lucille Shapiro, Ping Hu, Gary L. Andersen
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Publication number: 20120259607Abstract: The present invention provides a method of a method of designing an implementation of a DNA assembly. In an exemplary embodiment, the method includes (1) receiving a list of DNA sequence fragments to be assembled together and an order in which to assemble the DNA sequence fragments. (2) designing DNA oligonucleotides (oligos) for each of the DNA sequence fragments, and (3) creating a plan for adding flanking homology sequences to each of the DNA oligos. In an exemplary embodiment, the method includes (1) receiving a list of DNA sequence fragments to be assembled together and an order in which to assemble the DNA sequence fragments, (2) designing DNA oligonucleotides (oligos) for each of the DNA sequence fragments, and (3) creating a plan for adding optimized overhang sequences to each of the DNA oligos.Type: ApplicationFiled: February 1, 2012Publication date: October 11, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventor: Nathan J. Hillson
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Publication number: 20120258487Abstract: This invention provides methods and compositions for assembling biological constructs (e.g., plasmids, transformed cells, etc.). In certain embodiments the methods involve encapsulating separate components of said biological construct each in a fluid droplet confined in a fluid channel; optionally mixing droplets from different fluid channels to for a sequenced order of droplets carrying different components of said biological construct in a channel or chamber; and optionally combining two or more droplets each containing different components of said biological construct to permit said components to react with each other in one or more reactions contributing to the assembly of said biological construct.Type: ApplicationFiled: April 2, 2012Publication date: October 11, 2012Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SANDIA CORPORATIONInventors: Chieh Chang, Rajiv Bharadwaj, Anup K. Singh, Aarthi Chandrasekaran, Nathan J. Hillson
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Publication number: 20110117590Abstract: Compositions and methods are provided for detection of certain heavy metals using bacterial whole cell biosensors.Type: ApplicationFiled: February 6, 2008Publication date: May 19, 2011Inventors: Nathan J. Hillson, Lucille Shapiro, Ping Hu, Gary L. Andersen