Abstract: Disclosed are methods and systems to detect a class of non-variola Orthopoxviruses, and, more particularly, monkeypox virus. In certain embodiments, the method may comprise obtaining a sample from the subject; and detecting a nucleic acid sequence specific to the non-variola Orthopoxvirus. In some embodiments, the method may further isolation of the non-variola Orthopoxvirus from a solid substrate such as a tissue swab and further purification of viral nucleic acid using silica beads. The sample may in some cases be self-collected by a subject. The disclosed methods and systems, including kits for self-collection, may be used for a high throughput assay allowing for screening of hundreds of samples per day.

Abstract: Methods and apparatuses for detecting full waste canister and/or fluid flow path blockage conditions are disclosed. Also disclosed are methods and apparatuses for controlling a pump. In some embodiments, flow of fluid can be restricted in a portion of the fluid flow path. A controller can be configured to compare a difference in pressure values upstream and downstream of a fluid flow restrictor to a pressure difference threshold, and determine based on the comparison whether to activate an alarm indicating the full waste canister condition or the fluid flow path blockage condition. The controller can be additionally or alternatively configured to determine a fluid flow using a flow meter, open a selectable valve in response to a comparison of the fluid flow with a fluid flow threshold, determine fluid flow after opening the valve, and determine based on the fluid flow after opening the valve whether to activate the alarm.

Abstract: A novel maize variety designated X18N926 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X18N926 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X18N926 through backcrossing or genetic transformation, and to the maize seed, plant and plant part produced thereby are described. Maize variety X18N926, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X18N926 are provided. Methods for producing maize varieties derived from maize variety X18N926 and methods of using maize variety X18N926 are disclosed.

Abstract: In some aspects, provided herein are antibodies or antigen-binding fragments that bind to CD200R, a glycoprotein receptor present on cell surfaces. Antibodies or antigen-binding fragments provided herein, in some cases, agonize CD200R signaling pathway that inhibits inflammation and immune response. In other aspects, provided herein are compositions, methods of use, methods of making, polynucleotides, vectors, host cells, and kits relating to antibodies or antigen-binding fragments that bind to CD200R.

Abstract: A method for aligning coordinate systems from separate augmented reality (AR) devices is described. In one aspect, the method includes generating predicted depths of a first point cloud by applying a pre-trained model to a first single image generated by a first monocular camera of a first augmented reality (AR) device, and first sparse 3D points generated by a first SLAM system at the first AR device, generating predicted depths of a second point cloud by applying the pre-trained model to a second single image generated by a second monocular camera of the second AR device, and second sparse 3D points generated by a second SLAM system at the second AR device, determining a relative pose between the first AR device and the second AR device by registering the first point cloud with the second point cloud.

Abstract: A dosage form, other than a 50 g or 75 g dose of glucose, that allows large dose combinations of two or more health ingredients selected from at least one of water soluble, water insoluble and lipid-based ingredients to be formulated together in a single dosage form, which is a drinkable gel with a volume of between 25 ml and 250 ml. The health ingredients are retained in a delivery system including water, a gelling agent that is a carbohydrate non-ionic gelled polymer gelling agent and a polyvalent ion gelled polymer gelling agent, and a pH adjuster. The carbohydrate non-ionic gelled polymer gelling agent is an agarose-based polymer gelling agent, the polyvalent ion gelled polymer gelling agent is an alginate-based polymer gelling agent.

Abstract: A computer-implemented process is disclosed for generating a labeled overhead image of a geographical area. A plurality of ground level images of the geographical area is retrieved. A ground level feature map is generated, via a ground level convolutional neural network, based on features extracted from the plurality of ground level images. An overhead image of the geographical area is also retrieved. A joint feature map is generated, via an overhead convolutional neural network based on the ground level feature map and features extracted from the plurality of ground level images. Geospatial function values at a plurality of pixels of the overhead image are estimated based on at least the joint feature map and the overhead image. The plurality of pixels of the overhead image is labeled according to the estimated geospatial function values.

Abstract: A computer-implemented process is disclosed for generating a labeled overhead image of a geographical area. A plurality of ground level images of the geographical area is retrieved. A ground level feature map is generated, via a ground level convolutional neural network, based on features extracted from the plurality of ground level images. An overhead image of the geographical area is also retrieved. A joint feature map is generated, via an overhead convolutional neural network based on the ground level feature map and features extracted from the plurality of ground level images. Geospatial function values at a plurality of pixels of the overhead image are estimated based on at least the joint feature map and the overhead image. The plurality of pixels of the overhead image is labeled according to the estimated geospatial function values.

Abstract: A method for producing a mutant G-protein coupled receptor (GPCR) with increased stability relative to a parent GPCR, the method comprising making one or more mutations in the amino acid sequence that defines a Class 1 parent GPCR, wherein (i) the one or more mutations are located within a window of i plus or minus 5 residues, where i is the position of amino acid residue 3.55 in the parent GPCR, and/or (ii) the one or more mutations are located within a window of i minus 2 to i residues, where i is the position of amino acid residue 5.63 in the parent GPCR, and/or (iii) the one or more mutations are located within a window of i minus 4 to i plus 1 residues, where i is the position of amino acid residue 7.42 in the parent GPCR, to provide one or more mutants of the parent GPCR with increased stability.

Abstract: A method for producing a mutant G-protein coupled receptor (GPCR) with increased stability relative to a parent GPCR, the method comprising making one or more mutations in the amino acid sequence that defines a Class 1 parent GPCR, wherein (i) the one or more mutations are located within a window of i plus or minus 5 residues, where i is the position of amino acid residue 3.55 in the parent GPCR, and/or (ii) the one or more mutations are located within a window of i minus 2 to i residues, where i is the position of amino acid residue 5.63 in the parent GPCR, and/or (iii) the one or more mutations are located within a window of i minus 4 to i plus 1 residues, where i is the position of amino acid residue 7.42 in the parent GPCR, to provide one or more mutants of the parent GPCR with increased stability.

Abstract: A method of subdividing a representation of an object surface comprising a tessellated mesh of polygons is provided. The surface may be bounded by one or more boundary curves. One or more polygons in the mesh may be each subdivided into child polygons, each having one or more vertices. The result is a second mesh representation which may have a finer level of resolution than the original mesh. The locations or parameters of the vertices of the child polygons in the second mesh may be determined using suitable weightings of the locations or parameters of adjacent vertices in the original mesh. The locations of the vertices in the second mesh may be further refined through application of detail vectors. The locations of boundary vertices are always constrained to lie on one of the boundary curves bounding the surface in question. The method may continue iterating until the surface as represented by the subdivided surface representation is fine enough for the intended application.

Abstract: A method of trimming a mesh representation of an object surface comprising a tessellated mesh of polygons. A trim curve is projected onto the mesh representation to determine the trim area. Polygons within or intersecting the trim area are removed, and new polygons are introduced to attach the trimmed mesh to the trim curve projection. Detail data is formed for vertices of polygons near the trim curve, representing information about the object surface not present in the trimmed mesh representation. The detail data is applied to the vertices, thereby refining their locations. Any polygons near the trim curve which are outside a prescribed tolerance of the object surface are subdivided. The steps of forming and applying the detail data followed by the step of subdividing are iteratively performed until the trimmed mesh representation is within a prescribed tolerance of the object surface.

Abstract: A method of forming detail data corresponding to a vertex of a polygonal mesh representation of an object surface. The mesh representation has a limit surface, and the vertex has a limit point on the limit surface. The detail data for the vertex relates to the shape of the limit surface near the limit point corresponding to the vertex, and may capture detail about the object surface which is not captured by the mesh representation. The method may involve forming difference or detail data for one or more vertices from the group comprising the vertex in question and one or more neighboring vertices, weighting the resulting difference or detail data with prescribed weights, and deriving the detail data for the vertex in question from the weighted difference or detail data. The difference data for a vertex is the difference between the vertex as mapped onto the object surface and the limit point for the vertex on the limit surface.