Patents by Inventor Nathan Joseph Alves

Nathan Joseph Alves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REPORTER LABELED ANNULAR CLOT SYSTEM FOR DIAGNOSIS AND RESEARCH
    Publication number: 20240337669
    Abstract: Disclosed are compositions and methods of a microplate-based assay related to the field of thrombosis diagnosis, therapeutic screening, and drug development platforms.
    Type: Application
    Filed: August 4, 2022
    Publication date: October 10, 2024
    Inventors: Nathan Joseph Alves, Ziqian Zeng
  • ANTIBODY PURIFICATION VIA AFFINITY CHROMATOGRAPHY
    Publication number: 20170166607
    Abstract: Embodiments herein provide methods of purifying monoclonal and polyclonal anti-bodies (e.g., immunoglobulins) from biological fluids, such as cell lysates, cell supernatant and ascites fluids, using small molecule affinity chromatography. Various embodiments disclose a class of small molecules that selectively bind a nucleotide binding site that is inherent to all immunoglobulins, and in various embodiments, methods are disclosed that use one of these small molecules as a capture molecule in small molecule affinity chromatography. In some embodiments, the small molecule may be an indole, and in particular embodiments, the small molecule may be indole-3-butyric acid.
    Type: Application
    Filed: February 17, 2017
    Publication date: June 15, 2017
    Applicant: UNIVERSITY OF NOTRE DAME DU LAC
    Inventors: Zihni Basar Bilgicer, Tanyel Kiziltepe Bilgicer, Nathan Joseph Alves, Jonathan Darryl Ashley, Michael William Handlogten
  • Antibody purification via affinity chromatography
    Patent number: 9598460
    Abstract: Embodiments herein provide methods of purifying monoclonal and polyclonal antibodies (e.g., immunoglobulins) from biological fluids, such as cell lysates, cell supernatant and ascites fluids, using small molecule affinity chromatography. Various embodiments disclose a class of small molecules that selectively bind a nucleotide binding site that is inherent to all immunoglobulins, and in various embodiments, methods are disclosed that use one of these small molecules as a capture molecule in small molecule affinity chromatography. In some embodiments, the small molecule may be an indole, and in particular embodiments, the small molecule may be indole-3-butyric acid.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: March 21, 2017
    Assignee: UNIVERSITY OF NOTRE DAME DU LAC
    Inventors: Zihni Basar Bilgicer, Tanyel Kiziltepe Bilgicer, Nathan Joseph Alves, Jonathan Darryl Ashley, Michael William Handlogten
  • ANTIBODY PURIFICATION VIA AFFINITY CHROMATOGRAPHY
    Publication number: 20130309699
    Abstract: Embodiments herein provide methods of purifying monoclonal and polyclonal anti-bodies (e.g., immunoglobulins) from biological fluids, such as cell lysates, cell supernatant and ascites fluids, using small molecule affinity chromatography. Various embodiments disclose a class of small molecules that selectively bind a nucleotide binding site that is inherent to all immunoglobulins, and in various embodiments, methods are disclosed that use one of these small molecules as a capture molecule in small molecule affinity chromatography. In some embodiments, the small molecule may be an indole, and in particular embodiments, the small molecule may be indole-3-butyric acid.
    Type: Application
    Filed: January 18, 2012
    Publication date: November 21, 2013
    Applicant: UNIVERSITY OF NOTRE DAME DU LAC
    Inventors: Zihni Basar Bilgicer, Tanyel Kiziltepe Bilgicer, Nathan Joseph Alves, Jonathan Darryl Ashley, Michael William Handlogten