Patents by Inventor Nathan Jui

Nathan Jui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12065402
    Abstract: This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.
    Type: Grant
    Filed: May 22, 2023
    Date of Patent: August 20, 2024
    Assignee: EMORY UNIVERSITY
    Inventors: Eric Ortlund, Suzanne Mays, Nathan Jui, Autumn Flynn, Michael Dugan
  • Publication number: 20230295070
    Abstract: This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.
    Type: Application
    Filed: May 22, 2023
    Publication date: September 21, 2023
    Inventors: Eric Ortlund, Suzanne Mays, Nathan Jui, Autumn Flynn, Michael Dugan
  • Patent number: 11691939
    Abstract: This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: July 4, 2023
    Assignee: Emory University
    Inventors: Eric Ortlund, Suzanne Mays, Nathan Jui, Autumn Flynn, Michael Dugan
  • Publication number: 20210047258
    Abstract: This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.
    Type: Application
    Filed: October 15, 2020
    Publication date: February 18, 2021
    Inventors: Eric Ortlund, Suzanne Mays, Nathan Jui, Autumn Flynn, Michael Dugan
  • Patent number: 10843996
    Abstract: This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: November 24, 2020
    Assignee: Emory University
    Inventors: Eric Ortlund, Suzanne Mays, Nathan Jui, Autumn Flynn, Michael Dugan
  • Publication number: 20200017433
    Abstract: This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.
    Type: Application
    Filed: March 16, 2018
    Publication date: January 16, 2020
    Applicant: Emory University
    Inventors: Eric Ortlund, Suzanne Mays, Nathan Jui, Autumn Flynn, Michael Dugan
  • Patent number: 9790188
    Abstract: The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and pharmaceutical compositions thereof. The present invention also provides methods and kits using the inventive compounds and pharmaceutical compositions for treating and/or preventing diseases associated with protein aggregation, such as amyloidoses (e.g., Parkinson's disease and Alzheimer's disease), treating and/or preventing neurodegenerative diseases, treating and/or preventing diseases associated with Tar DNA binding protein 43 kDa, reducing or preventing protein aggregation, and/or modulating E3 ubiquitin ligase in a subject in need thereof.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: October 17, 2017
    Assignees: Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
    Inventors: Susan L. Lindquist, Stephen L. Buchwald, Daniel Tardiff, Nathan Jui
  • Publication number: 20160031824
    Abstract: The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and pharmaceutical compositions thereof. The present invention also provides methods and kits using the inventive compounds and pharmaceutical compositions for treating and/or preventing diseases associated with protein aggregation, such as amyloidoses (e.g., Parkinson's disease and Alzheimer's disease), treating and/or preventing neurodegenerative diseases, treating and/or preventing diseases associated with Tar DNA binding protein 43 kDa, reducing or preventing protein aggregation, and/or modulating E3 ubiquitin ligase in a subject in need thereof.
    Type: Application
    Filed: March 17, 2014
    Publication date: February 4, 2016
    Applicants: Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
    Inventors: Susan L. Lindquist, Stephen L. Buchwald, Daniel Tardiff, Nathan Jui