Patents by Inventor Nathan Karin

Nathan Karin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CXCL9 AND VARIANTS THEREOF FOR IMMUNOTHERAPY OF CANCER DISEASES
    Publication number: 20230242606
    Abstract: The invention provides a modified CXCL9 polypeptide comprising an insertion of an additional amino acid at the N-terminus of a corresponding wild type CXCL9, a pharmaceutical composition comprising the same and a method for the production thereof and of using the same for treating cancer. Further provided nucleic acids encoding the modified CXCL9 polypeptides of the invention, vectors and host cells comprising the same.
    Type: Application
    Filed: June 21, 2021
    Publication date: August 3, 2023
    Inventors: Nathan KARIN, Ghada JARROUS
  • MODIFIED CXCL10 FOR IMMUNOTHERAPY OF CANCER DISEASES
    Publication number: 20230212247
    Abstract: The invention provides a modified CXCL10 polypeptide, comprising an insertion of an additional amino acid at the N-terminus of a corresponding wild type CXCL10, pharmaceutical composition comprising the same and method for using thereof for treating cancer.
    Type: Application
    Filed: December 13, 2022
    Publication date: July 6, 2023
    Inventors: Nathan KARIN, Ghada JARROUS
  • Epitope as a target for therapy of inflammatory autoimmune diseases and graft rejection
    Patent number: 10975122
    Abstract: The present invention relates to a peptide comprising an epitope within the macrophage scavenger receptor B-I, a method of using the same, a nucleic acid encoding the same and an antibody that binds to the epitope.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: April 13, 2021
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Nathan Karin, Gizi Wildbaum
  • NOVEL EPITOPE AS A TARGET FOR THERAPY OF INFLAMMATORY AUTOIMMUNE DISEASES AND GRAFT REJECTION
    Publication number: 20170304436
    Abstract: The present invention relates to a peptide comprising an epitope within the macrophage scavenger receptor B-I, a method of using the same, a nucleic acid encoding the same and an antibody that binds to the epitope.
    Type: Application
    Filed: November 11, 2015
    Publication date: October 26, 2017
    Applicant: RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL SCIENCES
    Inventors: Nathan KARIN, Gizi WILDBAUM
  • Use of CCL1 in therapy
    Patent number: 9717777
    Abstract: A method of treating a medical condition in which suppression of effector T cells is beneficial in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of a CCL1 polypeptide, thereby treating the medical condition in the subject.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: August 1, 2017
    Assignee: RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL SCIENCES
    Inventors: Nathan Karin, Yiftah Barsheshet, Gizi Wildbaum
  • Compositions and methods for diagnosing and treating an inflammation
    Patent number: 9670282
    Abstract: A method of treating multiple sclerosis (MS) in a subject in need thereof, the method comprising administering to said subject a therapeutically effective amount of an isolated polypeptide comprising an antigen recognition domain capable of specifically binding a human scavenger receptor, wherein said antigen recognition domain comprises CDR amino acid sequences as set forth in SEQ ID NO: 11, 15, 19, 23, 27 and 31, thereby treating MS in the subject.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: June 6, 2017
    Assignee: RAPPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL SCIENCES
    Inventors: Nathan Karin, Rachel Anunu, Gizi Wildbaum, Yaniv Zohar, Nir Netzer
  • Compositions and methods for diagnosing and treating an inflammation
    Patent number: 9611324
    Abstract: A method of reducing an inflammatory response in a subject is provided. The method comprising providing to a subject in need thereof a therapeutically effective amount of an agent capable of reducing activity and/or expression of a scavenger receptor or of an effector thereof, thereby reducing the inflammatory response in the subject.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: April 4, 2017
    Assignee: RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL SERVICES
    Inventors: Nathan Karin, Gizi Wildbaum, Rachel Anunu, Yaniv Zohar, Nir Netzer
  • USE OF CCL1 IN THERAPY
    Publication number: 20160303196
    Abstract: A method of treating a medical condition in which suppression of effector T cells is beneficial in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of a CCL1 polypeptide, thereby treating the medical condition in the subject.
    Type: Application
    Filed: May 25, 2016
    Publication date: October 20, 2016
    Inventors: Nathan KARIN, Yiftah Barsheshet, Gizi Wildbaum
  • COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING AN INFLAMMATION
    Publication number: 20160280785
    Abstract: A method of treating multiple sclerosis (MS) in a subject in need thereof, the method comprising administering to said subject a therapeutically effective amount of an isolated polypeptide comprising an antigen recognition domain capable of specifically binding a human scavenger receptor, wherein said antigen recognition domain comprises CDR amino acid sequences as set forth in SEQ ID NO: 11, 15, 19, 23, 27 and 31, thereby treating MS in the subject.
    Type: Application
    Filed: May 18, 2016
    Publication date: September 29, 2016
    Inventors: Nathan KARIN, Rachel Anunu, Gizi Wildbaum, Yaniv Zohar, Nir Netzer
  • Compositions and methods for diagnosing and treating an inflammation
    Patent number: 9371385
    Abstract: A method of treating a graft rejection disease in a subject in need thereof, the method comprising administering to said subject a therapeutically effective amount of an isolated polypeptide comprising an antigen recognition domain capable of specifically binding a human scavenger receptor, wherein said antigen recognition domain comprises CDR amino acid sequences as set forth in SEQ ID NO: 11, 15, 19, 23, 27 and 31, thereby treating the graft rejection disease in the subject.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: June 21, 2016
    Assignee: RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL SCIENCES
    Inventors: Nathan Karin, Rachel Anunu, Gizi Wildbaum, Yaniv Zohar, Nir Netzer
  • Use of CCL1 in therapy
    Patent number: 9352000
    Abstract: A method of treating a medical condition in which suppression of effector T cells is beneficial in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of a CCL1 polypeptide, thereby treating the medical condition in the subject.
    Type: Grant
    Filed: May 5, 2011
    Date of Patent: May 31, 2016
    Assignee: RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL SCIENCES
    Inventors: Nathan Karin, Yiftah Barsheshet, Gizi Wildbaum
  • COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING AN INFLAMMATION
    Publication number: 20150344569
    Abstract: A method of treating a graft rejection disease in a subject in need thereof, the method comprising administering to said subject a therapeutically effective amount of an isolated polypeptide comprising an antigen recognition domain capable of specifically binding a human scavenger receptor, wherein said antigen recognition domain comprises CDR amino acid sequences as set forth in SEQ ID NO: 11, 15, 19, 23, 27 and 31, thereby treating the graft rejection disease in the subject.
    Type: Application
    Filed: August 18, 2015
    Publication date: December 3, 2015
    Inventors: Nathan KARIN, Rachel Anunu, Gizi Wildbaum, Yaniv Zohar, Nir Netzer
  • Compositions and methods for diagnosing and treating an inflammation
    Patent number: 9145460
    Abstract: An isolated polypeptide is provided. The polypeptide comprising an antigen recognition domain capable of specifically binding a human scavenger receptor, wherein the antigen recognition domain comprises at least three CDR amino acid sequences selected from the group consisting of SEQ ID NO: 11, 15, 19, 23, 27 and 31. Also provided are compositions which comprise the peptide and uses of same.
    Type: Grant
    Filed: June 10, 2013
    Date of Patent: September 29, 2015
    Assignee: RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL SCIENCES
    Inventors: Nathan Karin, Rachel Anunu, Gizi Wildbaum, Yaniv Zohar, Nir Netzer
  • COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING AN INFLAMMATION
    Publication number: 20150218272
    Abstract: A method of reducing an inflammatory response in a subject is provided. The method comprising providing to a subject in need thereof a therapeutically effective amount of an agent capable of reducing activity and/or expression of a scavenger receptor or of an effector thereof, thereby reducing the inflammatory response in the subject.
    Type: Application
    Filed: April 16, 2015
    Publication date: August 6, 2015
    Inventors: Nathan KARIN, Gizi WILDBAUM, Rachel ANUNU, Yaniv ZOHAR, Nir NETZER
  • Compositions and methods for diagnosing and treating an inflammation
    Patent number: 9023349
    Abstract: A method of reducing an inflammatory response in a subject is provided. The method comprising providing to a subject in need thereof a therapeutically effective amount of an agent capable of reducing activity and/or expression of a scavenger receptor or of an effector thereof, thereby reducing the inflammatory response in the subject.
    Type: Grant
    Filed: June 10, 2013
    Date of Patent: May 5, 2015
    Assignee: Rappaport Family Institute for Research in the Medical Sciences
    Inventors: Nathan Karin, Gizi Wildbaum, Rachel Anunu, Yaniv Zohar, Nir Netzer
  • COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING AN INFLAMMATION
    Publication number: 20140161823
    Abstract: An isolated polypeptide is provided. The polypeptide comprising an antigen recognition domain capable of specifically binding a human scavenger receptor, wherein the antigen recognition domain comprises at least three CDR amino acid sequences selected from the group consisting of SEQ ID NO: 11, 15, 19, 23, 27 and 31. Also provided are compositions which comprise the peptide and uses of same.
    Type: Application
    Filed: June 10, 2013
    Publication date: June 12, 2014
    Applicant: Rappaport Family Institute for Research in the Medical Sciences
    Inventors: Nathan KARIN, Rachel Anunu, Gizi Wildbaum, Yaniv Zohar, Nir Netzer
  • Compositions and methods for diagnosing and treating an inflammation
    Patent number: 8658375
    Abstract: A method of reducing an inflammatory response in a subject is provided. The method comprising providing to a subject in need thereof a therapeutically effective amount of an agent capable of reducing activity and/or expression of a scavenger receptor or of an effector thereof, thereby reducing the inflammatory response in the subject.
    Type: Grant
    Filed: August 9, 2011
    Date of Patent: February 25, 2014
    Assignee: Rappaport Family Institue for Research in the Medical Sciences
    Inventors: Nathan Karin, Gizi Wildbaum, Rachel Anunu, Yaniv Zohar, Nir Netzer
  • COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING AN INFLAMMATION
    Publication number: 20130259874
    Abstract: A method of reducing an inflammatory response in a subject is provided. The method comprising providing to a subject in need thereof a therapeutically effective amount of an agent capable of reducing activity and/or expression of a scavenger receptor or of an effector thereof, thereby reducing the inflammatory response in the subject.
    Type: Application
    Filed: June 10, 2013
    Publication date: October 3, 2013
    Inventors: Nathan KARIN, Gizi Wildbaum, Rachel Anunu, Yaniv Zohar, Nir Netzer
  • Compositions and methods for diagnosing and treating an inflammation
    Patent number: 8512698
    Abstract: An isolated polypeptide is provided. The polypeptide comprising an antigen recognition domain capable of specifically binding a human scavenger receptor, wherein the antigen recognition domain comprises at least three CDR amino acid sequences selected from the group consisting of SEQ ID NO: 11, 15, 19, 23, 27 and 31. Also provided are compositions which comprise the peptide and uses of same.
    Type: Grant
    Filed: September 11, 2006
    Date of Patent: August 20, 2013
    Assignee: Rappaport Family Institute for Research in the Medical Sciences
    Inventors: Nathan Karin, Rachel Anunu, Gizi Wildbaum, Yaniv Zohar, Nir Netzer
  • Compositions and methods for diagnosing and treating prostate cancer
    Patent number: 8486641
    Abstract: A method of diagnosing and determining a predisposition to prostate cancer is provided. The method comprising determining levels of MCP-1 antibodies and PSA in a sample of a subject and comparing to the level in healthy male controls, thereby diagnosing and determining a predisposition to the prostate cancer in the subject.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: July 16, 2013
    Assignee: Rappaport Family Institute for Research in the Medical Sciences
    Inventor: Nathan Karin