Patents by Inventor Nathan Klapoetke
Nathan Klapoetke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11274128Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.Type: GrantFiled: May 28, 2020Date of Patent: March 15, 2022Assignees: Massachusetts Institute of Technology, The Governors of the University of AlbertaInventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
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Patent number: 10882892Abstract: CsChrimson light-activated ion channel polypeptides, their encoding polynucleotides, and variants thereof are provided. Methods of introducing and using CsChrimson light activated ion channels and variants thereof for to alter cell activity and function are also provided.Type: GrantFiled: August 4, 2015Date of Patent: January 5, 2021Assignees: Massachusetts Institute of Technology, The Governors of The University of AlbertaInventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
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Patent number: 10717769Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.Type: GrantFiled: August 2, 2019Date of Patent: July 21, 2020Assignees: Massachusetts Institute of Technology, The Governors of the University of AlbertaInventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane KA-Shu Wong, Yongku Peter Cho
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Patent number: 10711044Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.Type: GrantFiled: September 13, 2019Date of Patent: July 14, 2020Assignees: Massachusetts Institute of Technology, The Governors of the University of AlbertaInventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
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Publication number: 20200031883Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.Type: ApplicationFiled: September 13, 2019Publication date: January 30, 2020Applicants: Massachusetts Institute of Technology, The Governors of the University of AlbertaInventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
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Patent number: 10472398Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.Type: GrantFiled: November 12, 2012Date of Patent: November 12, 2019Assignees: Massachusetts Institute of Technology, The Governors of The University of AlbertaInventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
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Patent number: 10472399Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.Type: GrantFiled: November 23, 2016Date of Patent: November 12, 2019Assignees: Massachusetts Institute of Technology, The Governors of The University of AlbertaInventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
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Patent number: 10392426Abstract: The invention, in some aspects relates to light-activated ion channel polypeptides and encoding nucleic acids and also relates in part to compositions comprising light-activated ion channel polypeptides and methods using light-activated ion channel polypeptides to alter cell activity and function.Type: GrantFiled: February 6, 2015Date of Patent: August 27, 2019Assignees: Massachusetts Institute of Technology, The Governors of the University of Alberta, President and Fellows of Harvard CollegeInventors: Nathan Klapoetke, Edward Boyden, Yongku Cho, Brian Y. Chow, Gane K. S. Wong, Adam E. Cohen, Daniel R. Hochbaum
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Patent number: 10106584Abstract: Compositions and methods for altering cell activity and function by expressing a light-activated ion pump polypeptide in a cell and contacting the cell with light that activates the expressed light-activated ion pump polypeptide. In some aspects of the invention, a light-activated ion pump polypeptide is a modified haloarcula halorhodopsin polypeptide, for example, a modified Halo 57 polypeptide.Type: GrantFiled: September 30, 2016Date of Patent: October 23, 2018Assignee: Massachusetts Institute of TechnologyInventors: Amy Chuong, Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Xue Han
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Publication number: 20170174730Abstract: The invention, in some aspects relates to light-activated ion channel polypeptides and encoding nucleic acids and also relates in part to compositions comprising light-activated ion channel polypeptides and methods using light-activated ion channel polypeptides to alter cell activity and function.Type: ApplicationFiled: March 1, 2017Publication date: June 22, 2017Applicants: Massachusetts Institute of Technology, The Governors of the University of Alberta, President and Fellows of Harvard CollegeInventors: Nathan Klapoetke, Edward Boyden, Yongku Cho, Brian Y. Chow, Gane K.S. Wong, Adam E. Cohen, Daniel R. Hochbaum
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Publication number: 20170088590Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.Type: ApplicationFiled: November 23, 2016Publication date: March 30, 2017Applicants: Massachusetts Institute of Technology, The Governors of the University of AlbertaInventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
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Publication number: 20170044219Abstract: Compositions and methods for altering cell activity and function by expressing a light-activated ion pump polypeptide in a cell and contacting the cell with light that activates the expressed light-activated ion pump polypeptide. In some aspects of the invention, a light-activated ion pump polypeptide is a modified haloarcula halorhodopsin polypeptide, for example, a modified Halo 57 polypeptide.Type: ApplicationFiled: September 30, 2016Publication date: February 16, 2017Applicant: Massachusetts Institute of TechnologyInventors: Amy Chuong, Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Xue Han
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Patent number: 9500641Abstract: Compositions and methods for altering cell activity and function by expressing a light-activated ion pump polypeptide in a cell and contacting the cell with light that activates the expressed light-activated ion pump polypeptide. In some aspects of the invention, a light-activated ion pump polypeptide is a modified haloarcula halorhodopsin polypeptide, for example, a modified Halo 57 polypeptide.Type: GrantFiled: January 20, 2015Date of Patent: November 22, 2016Assignee: Massachusetts Institute of TechnologyInventors: Amy Chuong, Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Xue Han
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Publication number: 20160039902Abstract: CsChrimson light-activated ion channel polypeptides, their encoding polynucleotides, and variants thereof are provided. Methods of introducing and using CsChrimson light activated ion channels and variants thereof for to alter cell activity and function are also provided.Type: ApplicationFiled: August 4, 2015Publication date: February 11, 2016Applicants: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
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Publication number: 20150223679Abstract: The invention, in some aspects relates to light-activated ion channel polypeptides and encoding nucleic acids and also relates in part to compositions comprising light-activated ion channel polypeptides and methods using light-activated ion channel polypeptides to alter cell activity and function.Type: ApplicationFiled: February 6, 2015Publication date: August 13, 2015Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE GOVERNORS OF THE UNIVERSITY OF ALBERTAInventors: Nathan Klapoetke, Edward Boyden, Yongku Cho, Brian Y. Chow, Gane K.S. Wong, Adam E. Cohen, Daniel R. Hochbaum
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Publication number: 20150192567Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the use of light-activated ion pumps (LAIPs).Type: ApplicationFiled: January 20, 2015Publication date: July 9, 2015Inventors: Amy Chuong, Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Xue Han
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Patent number: 8957028Abstract: The invention, in some aspects, relates to compositions and methods for altering cell activity and function. The invention also relates, in part, to the use of light-activated ion pumps (LAIPs) such as a light-activated ion pump polypeptide that when expressed in an excitable cell and contacted with a red light silences the excitable cell, wherein the polypeptide sequence of the light-activated ion pump comprises a wild-type or modified halomicrobium or haloarcula halorhodopsin polypeptide sequence.Type: GrantFiled: November 14, 2011Date of Patent: February 17, 2015Assignee: Massachusetts Institute of TechnologyInventors: Amy Chuong, Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Xue Han
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Publication number: 20140324134Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.Type: ApplicationFiled: November 12, 2012Publication date: October 30, 2014Applicants: Massachusetts Institute of Technology, The Governrs of the University of AlbertaInventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
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Publication number: 20120214188Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the use of light-activated ion channels (LAICs).Type: ApplicationFiled: November 14, 2011Publication date: August 23, 2012Inventors: Nathan Klapoetke, Amy Chuong, Brian Yichiun Chow, Edward Boyden, Xue Han, Gane Ka-Shu Wong
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Publication number: 20120121542Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the use of light-activated ion pumps (LAIPs).Type: ApplicationFiled: November 14, 2011Publication date: May 17, 2012Inventors: Amy Chuong, Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Xue Han